PSTPIP1 and WASL

Number of citations of the paper that reports this interaction (PMID 16418535)
97

Data Source:
BioGRID (pull down)

		PSTPIP1	WASL
Gene Name		proline-serine-threonine phosphatase interacting protein 1	Wiskott-Aldrich syndrome-like
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Uropod Actomyosin Contractile Ring Cytosol Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm	Nucleus Cytosol Plasma Membrane Actin Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Lamellipodium Actin Cap Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding Protein Phosphatase Binding	Actin Binding Small GTPase Regulator Activity Protein Binding
	Biological Process	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Innate Immune Response	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Membrane Budding Movement Of Cell Or Subcellular Component Mitotic Nuclear Division Axon Guidance Actin Polymerization Or Depolymerization Response To Bacterium Vesicle Organization Vesicle Transport Along Actin Filament Regulation Of Protein Localization Cellular Protein Complex Localization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Nitric Oxide Metabolic Process Ephrin Receptor Signaling Pathway Regulation Of Nitric-oxide Synthase Activity Cell Division Positive Regulation Of Filopodium Assembly Spindle Localization Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System	Axon guidance DCC mediated attractive signaling EPHB-mediated forward signaling Metabolism of nitric oxide NOSTRIN mediated eNOS trafficking EPH-Ephrin signaling Nephrin interactions eNOS activation and regulation Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Platelet counts ( 22139419)
Protein-Protein Interactions		29 interactors: ABL1 BUB3 CD2 CD2AP DNM2 FAM90A1 FASLG FBXL18 KHDRBS1 LSM4 MEFV MVP PCDHB14 PRPF31 PTPN12 PTPN18 RTP5 SDCBP SH2D4A SHBG SPG7 TRAF3IP3 TULP3 UBE2W WAS WASF1 WASF2 WASL ZNF175	47 interactors: ABL1 ACTG1 ACTR2 ACTR3 APBB1 APP ARPC3 BAIAP2 CDC42 CTTN DNMBP EVL FCHSD2 FNBP1 FNBP1L GRB2 HP HSP90AA1 HSP90AB1 IPO5 ITSN1 ITSN2 LCK NCK1 NCK2 NCKIPSD PACSIN1 PACSIN2 PACSIN3 PFN1 PRPF40A PSTPIP1 PTK6 RHOJ RHOQ RNF8 RPL7AP66 SDCBP SH3GL3 SNX9 SRC TRIP10 VASP VIPR1 WIPF1 WIPF2 ZNF395
Entrez ID		9051	8976
HPRD ID		05891	05448
Ensembl ID		ENSG00000140368	ENSG00000106299
Uniprot IDs		O43586	O00401
PDB IDs		2DIL	2FF3 2LNH 2VCP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Negative Regulation Of Membrane Tubulation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Nucleation Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Positive Regulation Of Interferon-gamma Secretion Regulation Of Cytoskeleton Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Actin Cytoskeleton Organization Actin Filament-based Movement Actin Filament-based Process Mitotic Cell Cycle Process Substrate-dependent Cell Migration, Cell Extension Cellular Component Assembly Regulation Of Oxidoreductase Activity Regulation Of Cellular Component Organization Mitotic Cell Cycle Signaling Actin Polymerization Or Depolymerization Cytoskeleton Organization Cell Communication Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Signal Transduction Rac Protein Signal Transduction Cell Projection Assembly Actin Filament Organization Mitotic Nuclear Division Nitric Oxide Metabolic Process Regulation Of Catalytic Activity Reactive Nitrogen Species Metabolic Process Endocytosis Cell Cycle Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Endothelial Cell Apoptotic Process Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Substrate-dependent Cell Migration Organelle Organization Positive Regulation Of Organelle Organization Regulation Of Nitric-oxide Synthase Activity	Endocytosis Vesicle-mediated Transport Actin Filament-based Process Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cytoskeleton Organization Cell Projection Morphogenesis Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Part Morphogenesis Neuron Projection Morphogenesis Axon Guidance Fc Receptor Signaling Pathway Axonogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Morphogenesis Positive Regulation Of Cellular Component Biogenesis Axon Development Neuron Projection Development Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Organization Phagocytosis Immune Response-regulating Signaling Pathway Neuron Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Chemotaxis Locomotion Actin Filament Organization Innate Immune Response Neuron Differentiation Organelle Organization Positive Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Positive Regulation Of Actin Filament Polymerization Generation Of Neurons Positive Regulation Of Protein Polymerization Positive Regulation Of Immune System Process Regulation Of Protein Complex Assembly Neurogenesis Regulation Of Actin Cytoskeleton Organization Immune System Process Anatomical Structure Morphogenesis Transport Defense Response Regulation Of Immune Response
Tagcloud ?		adipocyte biologically chick chicken chickens cutoff experimentally klf5 lpin1 luciferase map3k7 mettl14 microrna mir miranda mirna pck2 pdcd5 pycr2 slc2a2 splenocytes tardbp tnfsf10 transcriptionally tumourigenesis ube2e3 ubiquitously utrs vertebrate	148a biomarker biopsies cg consensus consequences downregulated dysregulated ectopic emsa hypermethylation integrin methylated micrornas mir mirna mirnas nasopharyngeal np npc oncogenes pivotal rock1 stimulatory supporting suppressing unmethylated usf1 vav2
Tagcloud (Difference) ?		adipocyte biologically chick chicken chickens cutoff experimentally klf5 lpin1 luciferase map3k7 mettl14 microrna miranda pck2 pdcd5 pycr2 slc2a2 splenocytes tardbp tnfsf10 transcriptionally tumourigenesis ube2e3 ubiquitously utrs vertebrate	148a biomarker biopsies cg consensus consequences downregulated dysregulated ectopic emsa hypermethylation integrin methylated micrornas mirnas nasopharyngeal np npc oncogenes pivotal rock1 stimulatory supporting suppressing unmethylated usf1 vav2
Tagcloud (Intersection) ?		mir mirna