PTPN12 and STX17

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		PTPN12	STX17
Description		protein tyrosine phosphatase non-receptor type 12	syntaxin 17
Image
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Projection Anchoring Junction	Autophagosome Membrane Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Smooth Endoplasmic Reticulum Membrane HOPS Complex SNARE Complex Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Autolysosome Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity SH3 Domain Binding	SNARE Binding SNAP Receptor Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Intracellular Protein Transport Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Fusion Autophagy Golgi Organization Vesicle-mediated Transport Autophagosome Membrane Docking Protein Localization To Phagophore Assembly Site Vesicle Docking Autophagosome-lysosome Fusion Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Autophagosome Maturation
Pathways		SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2	COPII-mediated vesicle transport
Drugs		Tiludronic acid
Diseases
GWAS		A body shape index ( 34021172) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Lymphocyte count ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alopecia areata ( 20596022) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223)
Interacting Genes		57 interacting genes: AATK ABL1 ANP32B APP BAG6 BCAR1 CCDC180 CGA CSH1 CSH2 CSK EFS EGFR ERBB3 ERBB4 FANCC FGFR2 FGFR4 FLT3 FRAT2 GRB2 IFT20 IGF1R INSR JAK2 KDR LMTK2 LPXN MYCBP2 NEDD9 PPP3R2 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PTK7 PXN RBM19 ROR2 SFRP4 SHC1 SMAD1 SMAD5 SORBS2 STX16 STX17 TENM1 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2 ZNF510	22 interacting genes: AURKA BUB1 CDH1 CTNNA1 DLC1 EGFR KRAS MAP2K4 MIS18A MLH1 MLH3 MSH2 NRAS ODC1 PTPN12 PTPN2 RB1 SMAD4 SNAP29 SRC STK11 TLR2
Entrez ID		5782	55014
HPRD ID		02513	05013
Ensembl ID		ENSG00000127947	ENSG00000136874
Uniprot IDs		B4E105 Q05209	P56962
PDB IDs		5HDE 5J8R 5O2P	4WY4 7BV4 7BV6
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Kinase Activity Signal Transduction Kinase Activity Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Autophosphorylation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphorylation Positive Regulation Of Signal Transduction Phosphorylation Receptor Complex Focal Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Population Proliferation Cellular Response To Growth Factor Stimulus ATP Binding Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Migration Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Cell Motility Positive Regulation Of Phosphate Metabolic Process Perinuclear Region Of Cytoplasm Response To Growth Factor Positive Regulation Of Locomotion Growth Hormone Receptor Signaling Pathway Animal Organ Development Regulation Of Developmental Process Positive Regulation Of Cell Population Proliferation Regulation Of Locomotion Insulin Receptor Substrate Binding Positive Regulation Of Protein Phosphorylation Anchoring Junction Positive Regulation Of Cellular Component Organization Positive Regulation Of Phosphorylation Regulation Of Cell Motility Positive Regulation Of Developmental Process	Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Mismatched DNA Binding Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Developmental Process ATP-dependent DNA Damage Sensor Activity Chiasma Regulation Of Developmental Process Apoptotic Signaling Pathway Reproductive Process Cytosol Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Development Mismatch Repair Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Apoptotic Process Negative Regulation Of ERBB Signaling Pathway Guanine/thymine Mispair Binding Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Apoptotic Process Negative Regulation Of Programmed Cell Death MAPK Cascade Programmed Cell Death Cellular Response To Indole-3-methanol Focal Adhesion Mismatch Repair Complex Cell Death Regulation Of Nervous System Development Negative Regulation Of Cell Differentiation Response To Indole-3-methanol Regulation Of Cell Population Proliferation LRR Domain Binding Positive Regulation Of Isotype Switching To IgA Isotypes Centromeric DNA Binding Cell Population Proliferation Nucleotide Binding Negative Regulation Of Nervous System Development Protein Kinase Activity ATP Binding Animal Organ Development Negative Regulation Of Signal Transduction Signal Transduction Regulation Of Protein Localization To Nucleus Anatomical Structure Morphogenesis Flotillin Complex Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Chromosome Organization Negative Regulation Of Cell Communication
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?