TMEM79 and SFTPC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM79	SFTPC
Description		transmembrane protein 79	surfactant protein C
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Membrane Trans-Golgi Network Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Epithelial Cell Maturation Hair Follicle Morphogenesis Cuticle Development Regulated Exocytosis Positive Regulation Of Epidermis Development Establishment Of Skin Barrier Cornification	Respiratory Gaseous Exchange By Respiratory System
Pathways			Surfactant metabolism Defective pro-SFTPC causes SMDP2 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4
Drugs
Diseases			Pulmonary surfactant metabolism dysfunction (SMDP)
GWAS		Glycated hemoglobin levels ( 24647736 28898252 29170429) Mean corpuscular hemoglobin concentration ( 20139978)	Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323)
Interacting Genes		36 interacting genes: ABO AMIGO1 ANKRD46 APOD ARL13B BRICD5 CLEC7A COQ9 CPLX4 CYB5R3 FAM209A FNDC9 GIMAP1 GPRC5D LDLRAD1 LPAR3 PELI2 PLN PLP2 PVR RNF8 RPRM SEC22A SERP1 SFTPC SLN TEX264 TMEM100 TMEM14C TMEM254 TMEM97 TMPRSS2 TMPRSS4 TNMD TRAM1L1 ZCCHC12	35 interacting genes: BSCL2 CD200R1 CD79A CLDN5 CPLX4 CREB3 CXCL9 FAM209A FNDC9 GJA8 GOLM1 GPR152 GPX8 HPN ICAM3 IFNGR2 KLRC1 LMNA LSMEM2 MUC1 NEDD4 PDZK1IP1 PQBP1 SEC22A SEC61G SIGLEC9 SMIM3 SYNE4 TMEM106C TMEM139 TMEM30B TMEM79 TMPRSS2 WWP1 WWP2
Entrez ID		84283	6440
HPRD ID		17481	01520
Ensembl ID		ENSG00000163472	ENSG00000168484
Uniprot IDs		Q9BSE2	A0A0S2Z4Q0 E5RI64 P11686
PDB IDs			2YAD 8OVI 8OX2
Enriched GO Terms of Interacting Partners?		Membrane Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Endoplasmic Reticulum Endoplasmic Reticulum Membrane Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of Intracellular Transport Negative Regulation Of ATP-dependent Activity Negative Regulation Of Calcium Ion Import Positive Regulation Of Viral Entry Into Host Cell Regulation Of Relaxation Of Muscle	Membrane Negative Regulation Of Potassium Ion Export Across Plasma Membrane
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