RNF8 and NBN

Number of citations of the paper that reports this interaction (PMID 23115235)
1

Data Source:
BioGRID (enzymatic study)

		RNF8	NBN
Gene Name		ring finger protein 8, E3 ubiquitin protein ligase	nibrin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleolus Midbody Site Of Double-strand Break	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Nucleolus PML Body Mre11 Complex Site Of Double-strand Break Nuclear Inclusion Body
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Ubiquitin Protein Ligase Binding Histone Binding Protein Homodimerization Activity	Damaged DNA Binding ATP-dependent DNA Helicase Activity Protein Binding Transcription Factor Binding Protein N-terminus Binding
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Spermatid Development Response To Ionizing Radiation Histone H2A Ubiquitination Histone H2B Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Interstrand Cross-link Repair Histone Exchange Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination Protein K48-linked Ubiquitination	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Blastocyst Growth DNA Repair Double-strand Break Repair Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Mitotic G2 DNA Damage Checkpoint Cell Proliferation Regulation Of DNA-dependent DNA Replication Initiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Autophosphorylation DNA Duplex Unwinding Positive Regulation Of Kinase Activity Isotype Switching Neuromuscular Process Controlling Balance Meiotic Cell Cycle Intrinsic Apoptotic Signaling Pathway
Pathways			ATM mediated phosphorylation of repair proteins Meiotic recombination DNA Damage/Telomere Stress Induced Senescence MRN complex relocalizes to nuclear foci ATM mediated response to DNA double-strand break Cellular Senescence Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks Homologous Recombination Repair Recruitment of repair and signaling proteins to double-strand breaks Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		35 interactors: BLM CCDC85B CEP44 CHD4 CHEK2 EXOSC2 H2AFX HIST2H2AC HIST2H2BE HOMEZ JMJD1C KDM4A MAD1L1 MDC1 MDM2 NBN PCNA PNMA2 RBFOX2 RXRA SEPT3 TMEM79 UBC UBE2D1 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V1 UBE2V2 UBE2W VCP WASL YEATS4	27 interactors: ATF2 ATM ATR BRCA1 CCNE1 CDK9 CHEK2 DCLRE1C EP300 FANCD2 H2AFX MDC1 MRE11A NCL PRKDC RAD18 RAD50 RECQL5 RNF8 SIRT1 TERF1 TLK1 TREX1 UBE2D1 UBE2N XRCC4 XRCC5
Entrez ID		9025	4683
HPRD ID		11521	04050
Ensembl ID		ENSG00000112130	ENSG00000104320
Uniprot IDs		O76064	O60934
PDB IDs		2CSW 2PIE 4AYC 4EPO
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Cellular Response To DNA Damage Stimulus Cell Cycle Checkpoint DNA Repair Mitotic Cell Cycle Checkpoint Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Double-strand Break Repair Cell Cycle Process Cellular Response To Stress Mitotic Cell Cycle Process Nucleobase-containing Compound Metabolic Process Cell Cycle Postreplication Repair Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination DNA Damage Checkpoint Protein K48-linked Ubiquitination Response To Stress Mitotic DNA Damage Checkpoint Nitrogen Compound Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Chromosome Organization Double-strand Break Repair Via Homologous Recombination Toll-like Receptor 4 Signaling Pathway Recombinational Repair Protein Catabolic Process DNA Double-strand Break Processing Regulation Of Nitrogen Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition	Cellular Response To DNA Damage Stimulus DNA Repair Cellular Response To Stress DNA Metabolic Process Double-strand Break Repair DNA Recombination Response To Ionizing Radiation Response To Stress Cell Cycle Process Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleobase-containing Compound Metabolic Process Response To Radiation Cell Cycle Checkpoint Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Damage Checkpoint DNA Replication Telomere Maintenance Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Response To DNA Damage Stimulus Cellular Response To Stimulus Mitotic Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Checkpoint Mitotic Cell Cycle Organelle Organization Response To Stimulus Response To Gamma Radiation Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of DNA Repair Negative Regulation Of Mitotic Cell Cycle Intra-S DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA Repair Negative Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of DNA Replication Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process
Tagcloud ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic plk1 properly recombination rnf168 s1618 spatiotemporally ubiquitinated	5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt mre11a nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald
Tagcloud (Difference) ?		53bp1 brca1 cdk1 comparatively coordinates cytosol enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic plk1 properly recombination rnf168 s1618 spatiotemporally ubiquitinated	5yrs atr brfr category cohorts decisions fail gains gleason guided igrt mre11a nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald
Tagcloud (Intersection) ?		atm ddr