RNF8 and UBE2V1

Number of citations of the paper that reports this interaction (PMID 21706008)
13

Data Source:
BioGRID (pull down)

		RNF8	UBE2V1
Gene Name		ring finger protein 8, E3 ubiquitin protein ligase	ubiquitin-conjugating enzyme E2 variant 1
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Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleolus Midbody Site Of Double-strand Break	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex UBC13-UEV1A Complex Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Ubiquitin Protein Ligase Binding Histone Binding Protein Homodimerization Activity	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Spermatid Development Response To Ionizing Radiation Histone H2A Ubiquitination Histone H2B Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Interstrand Cross-link Repair Histone Exchange Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination Protein K48-linked Ubiquitination	Protein Polyubiquitination Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of DNA Repair Postreplication Repair Regulation Of Transcription, DNA-templated Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Error-free Postreplication DNA Repair Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination
Pathways			Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Class I MHC mediated antigen processing & presentation Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex Innate Immune System TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		35 interactors: BLM CCDC85B CEP44 CHD4 CHEK2 EXOSC2 H2AFX HIST2H2AC HIST2H2BE HOMEZ JMJD1C KDM4A MAD1L1 MDC1 MDM2 NBN PCNA PNMA2 RBFOX2 RXRA SEPT3 TMEM79 UBC UBE2D1 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V1 UBE2V2 UBE2W VCP WASL YEATS4	36 interactors: ARIH2 BIRC2 BIRC3 BIRC8 CHFR DTX3 DZIP3 FAM168A KITLG MID1 MKRN3 PARK2 PELI1 PELI3 RNF10 RNF111 RNF14 RNF144A RNF185 RNF2 RNF5 RNF8 STUB1 SUMO4 TRAF2 TRAF3IP2 TRAF6 TRIM39 TRIM5 TRIM8 UBC UBE2N UBOX5 UBQLN1 XIAP ZNRF1
Entrez ID		9025	7335
HPRD ID		11521	04294
Ensembl ID		ENSG00000112130	ENSG00000244687
Uniprot IDs		O76064	Q13404
PDB IDs		2CSW 2PIE 4AYC 4EPO	2A4D 2C2V 2HLW
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Cellular Response To DNA Damage Stimulus Cell Cycle Checkpoint DNA Repair Mitotic Cell Cycle Checkpoint Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Double-strand Break Repair Cell Cycle Process Cellular Response To Stress Mitotic Cell Cycle Process Nucleobase-containing Compound Metabolic Process Cell Cycle Postreplication Repair Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination DNA Damage Checkpoint Protein K48-linked Ubiquitination Response To Stress Mitotic DNA Damage Checkpoint Nitrogen Compound Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Chromosome Organization Double-strand Break Repair Via Homologous Recombination Toll-like Receptor 4 Signaling Pathway Recombinational Repair Protein Catabolic Process DNA Double-strand Break Processing Regulation Of Nitrogen Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Cellular Protein Modification Process Protein K63-linked Ubiquitination Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein K48-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Protein Autoubiquitination Activation Of Innate Immune Response Protein Catabolic Process Regulation Of Innate Immune Response Ubiquitin-dependent Protein Catabolic Process Regulation Of Signaling Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Cellular Protein Catabolic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Intracellular Signal Transduction Cellular Macromolecule Catabolic Process Cellular Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Innate Immune Response Immune Response Regulation Of Protein Metabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Catabolic Process Positive Regulation Of Protein Metabolic Process Defense Response Response To Stress
Tagcloud ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic plk1 properly recombination rnf168 s1618 spatiotemporally ubiquitinated	activate autophosphorylation catalyse chains conjugated conjugating deubiquitination disassembly emanating ikk il1r lys map3k7 map3k7ip2 phosphorylates polyubiquitin polyubiquitinated polyubiquitination reconstituting tab2 tak1 toll traf6 ubc13 ubch5c ube2d3 ube2n uev1a unanchored
Tagcloud (Difference) ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic plk1 properly recombination rnf168 s1618 spatiotemporally ubiquitinated	activate autophosphorylation catalyse chains conjugated conjugating deubiquitination disassembly emanating ikk il1r lys map3k7 map3k7ip2 phosphorylates polyubiquitin polyubiquitinated polyubiquitination reconstituting tab2 tak1 toll traf6 ubc13 ubch5c ube2d3 ube2n uev1a unanchored
Tagcloud (Intersection) ?