RIPK1 and CDC42BPB

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		RIPK1	CDC42BPB
Gene Name		receptor (TNFRSF)-interacting serine-threonine kinase 1	CDC42 binding protein kinase beta (DMPK-like)
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Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Death-inducing Signaling Complex Receptor Complex Membrane Raft Ripoptosome	Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Cell Leading Edge Actomyosin Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Death Receptor Binding Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Identical Protein Binding Death Domain Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity ATP Binding Rho GTPase Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of JUN Kinase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Peptidyl-serine Autophosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Catabolic Process Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Protein Heterooligomerization Positive Regulation Of Necroptotic Process T Cell Apoptotic Process Necroptotic Process Regulation Of ATP:ADP Antiporter Activity Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Ripoptosome Assembly Necroptotic Signaling Pathway Ripoptosome Assembly Involved In Necroptotic Process Amyloid Fibril Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Phosphorylation Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Migration Actomyosin Structure Organization Actin Cytoskeleton Reorganization Intracellular Signal Transduction Regulation Of Catalytic Activity
Pathways		Regulation by c-FLIP Caspase-8 activation by cleavage Dimerization of procaspase-8 IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade RIP-mediated NFkB activation via ZBP1 Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Programmed Cell Death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 TRIF-mediated programmed cell death Innate Immune System
Drugs
Diseases
GWAS			Large B-cell lymphoma ( 21471979)
Protein-Protein Interactions		45 interactors: BIRC2 BIRC3 CASP8 CCDC50 CDC42BPB CFLAR CRADD EGFR FADD FAS HSP90AA1 IKBKB IKBKG ITCH MAP3K14 MAP3K3 MAP3K8 NFKB1 NUMBL OTUD1 PELI1 PTK2 RIPK3 RNF11 RNF216 SQSTM1 TAX1BP1 TICAM1 TNF TNFAIP3 TNFRSF10A TNFRSF10B TNFRSF1A TRADD TRAF1 TRAF2 TRAF3 TRAF5 TRIM38 TRPC4AP UBE2N USP2 XIAP YOD1 ZFAND5	3 interactors: CDC42 MAP2K5 RIPK1
Entrez ID		8737	9578
HPRD ID		04583	08516
Ensembl ID		ENSG00000137275	ENSG00000198752
Uniprot IDs		Q13546	Q86XZ8 Q9Y5S2
PDB IDs		4ITH 4ITI 4ITJ	3QFV 3TKU
Enriched GO Terms of Interacting Partners?		Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Signaling MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Protein Metabolic Process Innate Immune Response Positive Regulation Of Cellular Metabolic Process Signal Transduction Immune Response NIK/NF-kappaB Signaling Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signaling Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Type I Interferon Production Cellular Response To Mechanical Stimulus Cell Communication Defense Response Positive Regulation Of Protein Modification Process	Positive Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of MAPK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of JNK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Signal Transduction Activation Of MAPK Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of ATP:ADP Antiporter Activity Negative Regulation Of Signaling Regulation Of JNK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Stress-activated MAPK Cascade Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production ERK5 Cascade Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Necroptotic Process Positive Regulation Of MAP Kinase Activity Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process MAPK Cascade Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway Actin Filament Branching Amyloid Fibril Formation Submandibular Salivary Gland Formation Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation
Tagcloud ?		allowed autocrine back deficient endoplasmic er instead interacting intrinsic kills l929 lineage lymphotoxin mlkl necroptosis necrosis opportunities pathologies protect remarkably repression rescue reticulum ripk3 stress stressors switch tnfr1 unresolved	associating automated bace1 cation csnk2a1 disturbance disturbances enables gsk3 hallmark hela library linker localization m6pr mannose microtubule notably perturbation precise prkaca prkacg spatially states systematically throughput tracking trafficking visual
Tagcloud (Difference) ?		allowed autocrine back deficient endoplasmic er instead interacting intrinsic kills l929 lineage lymphotoxin mlkl necroptosis necrosis opportunities pathologies protect remarkably repression rescue reticulum ripk3 stress stressors switch tnfr1 unresolved	associating automated bace1 cation csnk2a1 disturbance disturbances enables gsk3 hallmark hela library linker localization m6pr mannose microtubule notably perturbation precise prkaca prkacg spatially states systematically throughput tracking trafficking visual
Tagcloud (Intersection) ?