RIPK1 and RNF11

Number of citations of the paper that reports this interaction (PubMedID 19131965)
41

Data Source:
HPRD (in vivo)

		RIPK1	RNF11
Description		receptor interacting serine/threonine kinase 1	ring finger protein 11
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Endosome Membrane Membrane Death-inducing Signaling Complex Protein-containing Complex Receptor Complex Ripoptosome	Ubiquitin Ligase Complex Nucleus Cytoplasm Endosome Early Endosome Recycling Endosome Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Death Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Death Domain Binding Protein Serine Kinase Activity	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Apoptotic Process Inflammatory Response Response To Oxidative Stress Signal Transduction Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Programmed Cell Death Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Tumor Necrosis Factor Intracellular Signal Transduction Peptidyl-serine Autophosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Protein Autophosphorylation Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Necroptotic Process Positive Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Interleukin-6-mediated Signaling Pathway T Cell Apoptotic Process Necroptotic Process Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Programmed Necrotic Cell Death Ripoptosome Assembly Necroptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of MiRNA Processing Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		Caspase activation via Death Receptors in the presence of ligand TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Regulation of necroptotic cell death Ub-specific processing proteases Ovarian tumor domain proteases Dimerization of procaspase-8 TNF signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IKK complex recruitment mediated by RIP1 Potential therapeutics for SARS Microbial modulation of RIPK1-mediated regulated necrosis SARS-CoV-1-mediated effects on programmed cell death Defective RIPK1-mediated regulated necrosis
Drugs		Fostamatinib
Diseases
GWAS		Cerebral white matter volume ( 31530798) Idiopathic osteonecrosis of the femoral head ( 28000841)	Atrial fibrillation ( 29290336) Male-pattern baldness ( 28196072) QRS duration ( 21076409)
Interacting Genes		49 interacting genes: ANKRD13A CASP8 CCDC50 CDC42BPB CFLAR CRADD CTNNB1 EGFR FADD FAS HSP90AA1 IKBKE IKBKG ITCH MAP3K14 MAP3K3 MAP3K8 MTDH NFKB1 NUMBL OTUD1 PPDPF PTK2 RIPK3 RNF11 RNF216 RPA1 SQSTM1 TAX1BP1 TBK1 TICAM1 TNF TNFAIP3 TNFRSF10A TNFRSF10B TNFRSF1A TRADD TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM38 TRIM72 TRPC4AP UBE2N USP21 YOD1 ZFAND5	69 interacting genes: AKT1 ANKRD13A ANKRD28 APP ASCC2 AUP1 CALCOCO2 CBLB CCDC127 DCUN1D1 EPN1 EPN2 EPN3 EPS15 ERCC6 FANCL GGA1 GGA2 GGA3 HERC1 HERC2 HUWE1 IKBKG ITCH MYO6 NEDD4 NEDD4L OPTN PDCD6IP POLI PTPRC QARS1 RABGEF1 RIPK1 RNF168 RNF216 RPS27A SDCBP SMURF1 SMURF2 SNRNP70 SPRTN STAM2 STAMBP TAX1BP1 TNFAIP3 TNIP1 TOM1L2 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBQLN2 UBQLN4 USP5 WWP1 WWP2 YAP1 ZFYVE16 ZFYVE9 ZNF350
Entrez ID		8737	26994
HPRD ID		04583	09955
Ensembl ID		ENSG00000137275	ENSG00000123091
Uniprot IDs		Q13546	Q9Y3C5
PDB IDs		4ITH 4ITI 4ITJ 4NEU 5HX6 5TX5 5V7Z 6AC5 6C3E 6C4D 6HHO 6NW2 6NYH 6OCQ 6R5F 6RLN 7CJB 7FCZ 7FD0 7XMK 7YDX 8I2N
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Death Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Cellular Response To Mechanical Stimulus Tumor Necrosis Factor Receptor Binding Positive Regulation Of Defense Response Response To Mechanical Stimulus Non-canonical NF-kappaB Signal Transduction Signaling Adaptor Activity Apoptotic Signaling Pathway Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Intracellular Signal Transduction Activation Of Immune Response Extrinsic Apoptotic Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Death-inducing Signaling Complex Regulation Of Defense Response Regulation Of Immune Response Response To Virus Positive Regulation Of Immune Response Immune System Process TRAIL-activated Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Response To External Biotic Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Activation Of Innate Immune Response Regulation Of Cell Communication Defense Response Immune Response-activating Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Response To Other Organism Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process	Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Macromolecule Catabolic Process Protein Polyubiquitination Proteolysis Ubiquitin Binding Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Activity Cytosol Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Endosome Ubiquitin Ligase Complex Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Negative Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Protein K63-linked Ubiquitination Positive Regulation Of Protein Catabolic Process K63-linked Polyubiquitin Modification-dependent Protein Binding Transferase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Negative Regulation Of Canonical NF-kappaB Signal Transduction Early Endosome Membrane Positive Regulation Of Protein Modification Process Autophagosome Protein-containing Complex Positive Regulation Of Post-translational Protein Modification DNA Damage Response Regulation Of Protein Ubiquitination Cytoplasm Cellular Response To Stress Extracellular Exosome
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