RIPK1 and CASP8

  • Number of citations of the paper that reports this interaction (PMID 10521396)
  • 107
  • Data Source:
  • BioGRID (affinity chromatography technology, imaging technique)
  • HPRD (in vivo, in vitro)

RIPK1

CASP8

Gene Name receptor (TNFRSF)-interacting serine-threonine kinase 1 caspase 8, apoptosis-related cysteine peptidase
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 45 interactors: BIRC2 BIRC3 CASP8 CCDC50 CDC42BPB CFLAR CRADD EGFR FADD FAS HSP90AA1 IKBKB IKBKG ITCH MAP3K14 MAP3K3 MAP3K8 NFKB1 NUMBL OTUD1 PELI1 PTK2 RIPK3 RNF11 RNF216 SQSTM1 TAX1BP1 TICAM1 TNF TNFAIP3 TNFRSF10A TNFRSF10B TNFRSF1A TRADD TRAF1 TRAF2 TRAF3 TRAF5 TRIM38 TRPC4AP UBE2N USP2 XIAP YOD1 ZFAND5 91 interactors: APAF1 APP AR ATG4D BCAP31 BCL2 BCL2L1 BFAR BID BIRC6 CASP1 CASP10 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8AP2 CASP9 CDH1 CDK11B CDKN1B CFLAR CHD3 CHUK COPS6 CRADD CTNNB1 DEDD DEDD2 EDA2R EIF2AK2 FADD FAF1 FAS FYN GMEB1 GRIA1 GZMB HDAC7 HECTD3 HIP1 IKBKB IKBKG ILK KRT18 MAP1LC3B MAP3K14 MAP4K4 MAPK1 MAPK3 MAPT NOD1 NOL3 NR1H4 PARK2 PARK7 PARP1 PARP2 PCYT1A PDIA6 PEA15 PIAS1 PICALM PLA2G4B PLEC PLIN4 PRDX6 PRKCI PRKCZ PSEN1 PSEN2 RALBP1 RB1 RIPK1 RIPK2 RYBP SNRPD3 SRF STK24 SUMO1 TFCP2 TNFRSF10A TNFRSF10B TOPORS TRAF1 TRAF2 TRAF6 USO1 VIM
Entrez ID 8737 841
HPRD ID 04583 03459
Ensembl ID ENSG00000137275 ENSG00000064012
Uniprot IDs Q13546 Q14790
PDB IDs 4ITH 4ITI 4ITJ 1F9E 1I4E 1QDU 1QTN 2C2Z 2FUN 2K7Z 2Y1L 3H11 3KJN 3KJQ 4JJ7
Enriched GO Terms of Interacting Partners?
Tagcloud ?
allowed  autocrine  back  deficient  endoplasmic  er  instead  interacting  intrinsic  kills  l929  lineage  lymphotoxin  mlkl  necroptosis  necrosis  opportunities  pathologies  protect  remarkably  repression  rescue  reticulum  ripk3  stress  stressors  switch  tnfr1  unresolved 
10mum  abeta42  abeta43  aif  carnosic  cascades  casp3  casp4  casp9  casps  concurrently  diterpene  herbs  ingestion  initiator  labiate  monomer  neurotoxicity  neurotrophic  oligomerization  oligomers  parp  phenolic  ribose  rosemary  sage  serves  sy5y 
Tagcloud (Difference) ?
allowed  autocrine  back  deficient  endoplasmic  er  instead  interacting  intrinsic  kills  l929  lineage  lymphotoxin  mlkl  necroptosis  necrosis  opportunities  pathologies  protect  remarkably  repression  rescue  reticulum  ripk3  stress  stressors  switch  tnfr1  unresolved 
10mum  abeta42  abeta43  aif  carnosic  cascades  casp3  casp4  casp9  casps  concurrently  diterpene  herbs  ingestion  initiator  labiate  monomer  neurotoxicity  neurotrophic  oligomerization  oligomers  parp  phenolic  ribose  rosemary  sage  serves  sy5y 
Tagcloud (Intersection) ?