CORO1B and SSH1

Number of citations of the paper that reports this interaction (PubMedID 17350576)
50

Data Source:
HPRD (in vitro, in vivo)

		CORO1B	SSH1
Description		coronin 1B	slingshot protein phosphatase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Lamellipodium Cell Leading Edge Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Glutamatergic Synapse	Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium Growth Cone Midbody Cell Leading Edge Cleavage Furrow Cell Projection Synapse
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding Cadherin Binding Actin Filament Binding Arp2/3 Complex Binding	Actin Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity
	Biological Process	Actin Filament Organization Cell Migration Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Endothelial Cell Chemotaxis Cellular Response To Platelet-derived Growth Factor Stimulus Wound Healing Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Organization Negative Regulation Of Smooth Muscle Cell Chemotaxis Actin Filament Branching Protein Localization To Cell Leading Edge Positive Regulation Of Lamellipodium Morphogenesis	Cell Morphogenesis Protein Dephosphorylation Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Synaptic Plasticity Regulation Of Protein Metabolic Process Cellular Response To ATP Excitatory Chemical Synaptic Transmission Positive Regulation Of AMPA Glutamate Receptor Clustering Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Excitatory Postsynaptic Potential
Pathways
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Non-response to citalopram or escitalopram and depression ( 27622933) Refractive error ( 32231278)	Brain morphology (MOSTest) ( 32665545) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean platelet volume ( 27863252) Platelet count ( 32888494)
Interacting Genes		9 interacting genes: ARPC2 FXR1 KPNA2 LHX4 POLR1C PRKCA SSH1 TERF1 TRIM15	6 interacting genes: ACTB AKT1 CFL1 CFL2 CORO1B DSTN
Entrez ID		57175	54434
HPRD ID		16743	09486
Ensembl ID		ENSG00000172725	ENSG00000084112
Uniprot IDs		Q9BR76	Q8WYL5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Positive Regulation Of Macromolecule Metabolic Process Regulation Of Viral Life Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Viral Penetration Into Host Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Cellular Component Organization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Protein Kinase C Signaling Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Protein-containing Complex Assembly Positive Regulation Of Shelterin Complex Assembly Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Actin Filament Polymerization Muscle Cell Projection Membrane Cell Leading Edge Regulation Of AMPA Glutamate Receptor Clustering Positive Regulation Of AMPA Glutamate Receptor Clustering Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Intracellular Transport Of Viral Material Mesodermal Cell Fate Determination Medial Motor Column Neuron Differentiation Nucleus Regulation Of Viral Process Positive Regulation Of Gene Expression Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Angiotensin-activated Signaling Pathway RNA Strand Annealing Activity Nuclear Pore Localization Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization To Telomere Fibrillar Center Shelterin Complex Negative Regulation Of Viral Life Cycle Desmosome Assembly	Actin Filament Fragmentation Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Actin Filament Severing Positive Regulation Of Protein Depolymerization Actin Filament-based Process Regulation Of Organelle Organization Positive Regulation Of Protein-containing Complex Disassembly Protein Depolymerization Glutamatergic Synapse Lamellipodium Actin Filament Binding Regulation Of Actin Filament Depolymerization Actin Polymerization Or Depolymerization Actin Filament Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Regulation Of Actin Cytoskeleton Organization Nitric-oxide Synthase Regulator Activity Actin Cytoskeleton Organization Regulation Of Protein Depolymerization Actin Binding Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Cell Motility Cellular Response To Ether Positive Regulation Of Cellular Component Organization Regulation Of Protein-containing Complex Disassembly Nuclear Matrix Regulation Of Cellular Component Organization Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Protein-containing Complex Disassembly Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Vesicle Response To Ether Positive Regulation Of Cytoskeleton Organization Cell-cell Junction Positive Regulation Of Lamellipodium Organization Regulation Of Cellular Component Size Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Response To Growth Factor Extracellular Exosome Regulation Of Lamellipodium Organization Response To Epidermal Growth Factor Cytoskeleton Organization
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