FBLIM1 and SHISA6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FBLIM1	SHISA6
Description		filamin binding LIM protein 1	shisa family member 6
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Stress Fiber Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Junction Anchoring Junction Cell Periphery	Postsynaptic Density Membrane AMPA Glutamate Receptor Complex Dendritic Spine Membrane Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse Asymmetric, Glutamatergic, Excitatory Synapse
	Molecular Function	Protein Binding Filamin Binding Metal Ion Binding	Protein Binding PDZ Domain Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Cell Adhesion Regulation Of Cell Shape Regulation Of Integrin Activation Cell-cell Adhesion	Spermatogenesis Wnt Signaling Pathway Regulation Of Short-term Neuronal Synaptic Plasticity Negative Regulation Of Canonical Wnt Signaling Pathway Postsynaptic Neurotransmitter Receptor Diffusion Trapping Excitatory Chemical Synaptic Transmission Regulation Of AMPA Glutamate Receptor Clustering
Pathways		Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Cardiac Troponin-T levels ( 23247143) Gut microbiota (bacterial taxa) ( 27723756) Heel bone mineral density ( 30598549)	Adventurousness ( 30643258) Copper levels ( 26025379) Daytime sleep phenotypes ( 27126917) Myopia ( 27182965) Obesity-related traits ( 23251661) Refractive error ( 23396134 32231278) Seborrheic dermatitis ( 29203360) Sleep duration (short sleep) ( 30846698) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		10 interacting genes: ACTMAP ADAT3 FERMT2 FLNA FLNB H3-5 H3C1 LMO3 SHISA6 TRIM15	29 interacting genes: ANKS1A ARMC7 BAG3 CARD9 CCDC57 CDKN1A CIAO1 CTBP2 CYSRT1 EXOSC5 FBLIM1 GOLGA2 HSF2BP KAT5 KIF9 KIFC3 KRT31 KRTAP3-3 LMO3 NEDD4 OIP5 PFDN5 PLEKHG4 SMARCD1 TLE5 TRIP6 TSSK3 TTC19 UBASH3A
Entrez ID		54751	388336
HPRD ID		09669	13507
Ensembl ID		ENSG00000162458	ENSG00000188803
Uniprot IDs		Q8WUP2	Q6ZSJ9
PDB IDs		2K9U 2W0P 4P3W
Enriched GO Terms of Interacting Partners?		Anchoring Junction Focal Adhesion Cell Cortex Actin Filament Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading SMAD Binding Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Actin Filament Bundle Assembly Cadherin Binding Protein Localization To Cell Junction Fc-gamma Receptor I Complex Binding Actin Binding Positive Regulation Of Protein Localization To Nucleus Tubulin Deacetylation Myb Complex Stress Fiber Structural Constituent Of Chromatin Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Intracellular Transport Of Viral Material Mesodermal Cell Fate Determination Initiator Methionyl Aminopeptidase Activity Cysteine-type Aminopeptidase Activity Formation Of Radial Glial Scaffolds Establishment Of Sertoli Cell Barrier Nucleosome Asymmetric, Glutamatergic, Excitatory Synapse Regulation Of AMPA Glutamate Receptor Clustering	Positive Regulation Of Aggrephagy
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