FBLIM1 and FLNB

Number of citations of the paper that reports this interaction (PubMedID 12496242)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		FBLIM1	FLNB
Description		filamin binding LIM protein 1	filamin B
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GO Annotations	Cellular Component	Fibrillar Center Stress Fiber Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Junction Anchoring Junction Cell Periphery	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Brush Border Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Z Disc Neuronal Cell Body Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Filamin Binding Metal Ion Binding	RNA Binding Actin Binding Protein Binding Identical Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Cell Adhesion Regulation Of Cell Shape Regulation Of Integrin Activation Cell-cell Adhesion	Keratinocyte Development Epithelial Cell Morphogenesis Signal Transduction Muscle Organ Development Skeletal Muscle Tissue Development Actin Cytoskeleton Organization Cell Differentiation Cellular Response To Type II Interferon
Pathways		Cell-extracellular matrix interactions	ISG15 antiviral mechanism
Drugs
Diseases			FLNB-related disorders, including: ; Atelostogenesis, type I; Boomerang dysplasia; Atelosteogenesis, type III; Larsen syndrome Spondylocarpotarsal synostosis syndrome
GWAS		Alcoholic chronic pancreatitis ( 28754779) Cardiac Troponin-T levels ( 23247143) Gut microbiota (bacterial taxa) ( 27723756) Heel bone mineral density ( 30598549)	A body shape index ( 34021172) Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Eating disorders (purging via substances) ( 23568457) Glaucoma (low intraocular pressure) ( 33627673) Gut microbiota (bacterial taxa) ( 27723756) Height ( 33713608 31217584) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Lymphocyte count ( 32888494) Neutrophil count ( 32888494) Optic cup area ( 31798171 28073927 25631615) Pulse pressure ( 30578418) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systemic sclerosis ( 31672989) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: ACTMAP ADAT3 FERMT2 FLNA FLNB H3-5 H3C1 LMO3 SHISA6 TRIM15	26 interacting genes: ASB2 ATF7IP DSCAM ERBB2 FBLIM1 FLNA FXR1 GP1BA HSPB1 ITGB1 ITGB3 ITGB6 MLH1 MYBPC2 NPHP1 PLEKHO1 PSEN1 PSEN2 RAD21 RNF216 SMURF2 SUMO2 TRIM55 TSC22D2 TSHR XIAP
Entrez ID		54751	2317
HPRD ID		09669	04543
Ensembl ID		ENSG00000162458	ENSG00000136068
Uniprot IDs		Q8WUP2	O75369
PDB IDs		2K9U 2W0P 4P3W	2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2DLG 2DMB 2DMC 2E9I 2E9J 2EE6 2EE9 2EEA 2EEB 2EEC 2EED 2WA5 2WA6 2WA7 3FER 4B7L 5DCP
Enriched GO Terms of Interacting Partners?		Anchoring Junction Focal Adhesion Cell Cortex Actin Filament Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading SMAD Binding Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Actin Filament Bundle Assembly Cadherin Binding Protein Localization To Cell Junction Fc-gamma Receptor I Complex Binding Actin Binding Positive Regulation Of Protein Localization To Nucleus Tubulin Deacetylation Myb Complex Stress Fiber Structural Constituent Of Chromatin Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Intracellular Transport Of Viral Material Mesodermal Cell Fate Determination Initiator Methionyl Aminopeptidase Activity Cysteine-type Aminopeptidase Activity Formation Of Radial Glial Scaffolds Establishment Of Sertoli Cell Barrier Nucleosome Asymmetric, Glutamatergic, Excitatory Synapse Regulation Of AMPA Glutamate Receptor Clustering	Cell-cell Adhesion Cell Adhesion Positive Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Protein Activation Cascade Synaptic Membrane Receptor Complex Integrin Complex Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Formation Of Radial Glial Scaffolds Positive Regulation Of L-glutamate Import Across Plasma Membrane Signal Transduction Ruffle Membrane Glycoprotein Ib-IX-V Complex C-X3-C Chemokine Binding Negative Regulation Of Apoptotic Process Regulation Of Anatomical Structure Morphogenesis Anchoring Junction Negative Regulation Of Programmed Cell Death Negative Regulation Of Multicellular Organismal Process Focal Adhesion Cell Migration Aspartic Endopeptidase Activity, Intramembrane Cleaving Cell Activation Gamma-secretase Complex Platelet Aggregation Blood Coagulation, Intrinsic Pathway Regulation Of L-glutamate Import Across Plasma Membrane Notch Receptor Processing Coreceptor Activity Protein Maturation Amyloid-beta Formation Cell Motility Homotypic Cell-cell Adhesion Regulation Of Tumor Necrosis Factor Production Glutamatergic Synapse Ubiquitin Protein Ligase Activity Positive Regulation Of Platelet Activation Cell Morphogenesis Actin Cytoskeleton Organization Wound Healing Positive Regulation Of Locomotion Neuromuscular Junction Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Mesodermal Cell Differentiation Cell Development Virus Receptor Activity
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