KDM4A

Name	lysine demethylase 4A
Structure
Novel Interactors	10 novel interactors: EIF2B3 EIF3I IPO13 KIF2C MAST2 MMACHC PIK3R3 PPIH ST3GAL3 TSPAN1
Interactors	6 interactors: H3C1 H4C1 RB1 RNF168 RNF8 RSPH1
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Oxidoreductase Activity Ubiquitin Protein Ligase Binding Histone Demethylase Activity Histone H3K9 Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Histone H4K20me2 Reader Activity Histone H3K36me2/H3K36me3 Demethylase Activity Histone H3K9me2/H3K9me3 Demethylase Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of Gene Expression Negative Regulation Of Autophagy Negative Regulation Of Gene Expression Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of DNA-templated Transcription
Pathways	HDMs demethylate histones Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
GWAS	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Household income (MTAG) ( 31844048 ) Menarche (age at onset) ( 25231870 ) Number of sexual partners ( 30643258 ) Perceived intensity of sweet substances ( 31005972 ) Red blood cell count ( 32888494 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 28991256 29483656 ) Smoking status (ever vs never smokers) ( 30643258 ) Squamous cell lung carcinoma ( 28604730 )
Entrez ID	9682
HPRD ID	17168
Ensembl ID	ENSG00000066135
Uniprot IDs	O75164
PDB IDs	2GF7 2GFA 2GP3 2GP5 2OQ6 2OQ7 2OS2 2OT7 2OX0 2P5B 2PXJ 2Q8C 2Q8D 2Q8E 2QQR 2QQS 2VD7 2WWJ 2YBK 2YBP 2YBS 3NJY 3PDQ 3RVH 3U4S 4AI9 4BIS 4GD4 4URA 4V2V 4V2W 5A7N 5A7O 5A7P 5A7Q 5A7S 5A7W 5A80 5ANQ 5D6W 5D6X 5D6Y 5F2S 5F2W 5F32 5F37 5F39 5F3C 5F3E 5F3G 5F3I 5F5I 5FPV 5FWE 5FY8 5FYC 5FYH 5FYI 5LY1 5LY2 5TVR 5TVS 5VAR 5VGI 5VMP 6CG1 6CG2 6G5W 6G5X 6H4O 6H4P 6H4Q 6H4R 6H4S 6H4T 6H4U 6H4V 6H4W 6H4X 6H4Y 6H8P 6HGT 7D4A 7EQV 8WD3 9GII 9GLE 9GP1 9GP4
GO Terms Enriched among Interactors ?	Protein Localization To Chromosome Chromatin Remodeling Epigenetic Regulation Of Gene Expression Chromosome Organization Chromosome Isotype Switching Somatic Diversification Of Immunoglobulins Involved In Immune Response DNA Repair-dependent Chromatin Remodeling Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Negative Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Transcription Elongation By RNA Polymerase II Cytoplasmic Translational Initiation Somatic Recombination Of Immunoglobulin Gene Segments Attachment Of Spindle Microtubules To Kinetochore Chromatin Organization Protein Localization To Chromosome, Centromeric Region B Cell Activation Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Interstrand Cross-link Repair Translation Initiation Factor Activity Cyanocobalamin Reductase (cyanide-eliminating) (NADP+) Activity Histone H2AK15 Ubiquitin Ligase Activity Double-strand Break Repair Via Nonhomologous End Joining B Cell Activation Involved In Immune Response