KDM4A

Gene Name		lysine (K)-specific demethylase 4A
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Methylated Histone Binding Histone Demethylase Activity (H3-K36 Specific)
	Biological Process	Chromatin Organization Transcription, DNA-templated Cardiac Muscle Hypertrophy In Response To Stress Viral Process Histone Demethylation Negative Regulation Of Transcription, DNA-templated Oxidation-reduction Process Histone H3-K36 Demethylation
Pathways		Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: HIST1H3A HIST1H4A RB1 RNF168 RNF8
Entrez ID		9682
HPRD ID		17168
Ensembl ID		ENSG00000066135
Uniprot IDs		O75164
PDB IDs		2GF7 2GFA 2GP3 2GP5 2OQ6 2OQ7 2OS2 2OT7 2OX0 2P5B 2PXJ 2Q8C 2Q8D 2Q8E 2QQR 2QQS 2VD7 2WWJ 2YBK 2YBP 2YBS 3NJY 3PDQ 3RVH 3U4S 4AI9 4GD4
Enriched GO Terms of Interacting Partners?		Chromatin Organization Histone H2A K63-linked Ubiquitination Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Replication-dependent Nucleosome Assembly Interstrand Cross-link Repair Chromatin Modification Nucleosome Organization DNA Methylation On Cytosine Histone H2A Ubiquitination Chromatin Silencing At RDNA Chromatin Remodeling Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Negative Regulation Of DNA-templated Transcription, Elongation Isotype Switching Protein K63-linked Ubiquitination Histone Exchange DNA Metabolic Process Chromatin Silencing Histone Ubiquitination Somatic Recombination Of Immunoglobulin Gene Segments Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of DNA Repair Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response Histone Modification Organelle Organization Regulation Of DNA-templated Transcription, Elongation DNA Methylation Immunoglobulin Production Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic DNA Modification Gene Silencing Regulation Of Transcription, DNA-templated Histone H2A-K13 Ubiquitination Histone H2A-K15 Ubiquitination Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Immune System Development Nucleosome Assembly
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