KDM4A and ST3GAL3

		KDM4A	ST3GAL3
Description		lysine demethylase 4A	ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytosol	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Golgi Cisterna Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Oxidoreductase Activity Ubiquitin Protein Ligase Binding Histone Demethylase Activity Histone H3K9 Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Histone H4K20me2 Reader Activity Histone H3K36me2/H3K36me3 Demethylase Activity Histone H3K9me2/H3K9me3 Demethylase Activity	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Protein Binding N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of Gene Expression Negative Regulation Of Autophagy Negative Regulation Of Gene Expression Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of DNA-templated Transcription	Protein Glycosylation Glycosphingolipid Biosynthetic Process Oligosaccharide Biosynthetic Process Ganglioside Biosynthetic Process Via Lactosylceramide Protein O-linked Glycosylation Via N-acetyl-galactosamine Keratan Sulfate Proteoglycan Biosynthetic Process Viral Protein Processing
Pathways		HDMs demethylate histones Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis Glycosphingolipid biosynthesis
Drugs
Diseases			Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Household income (MTAG) ( 31844048) Menarche (age at onset) ( 25231870) Number of sexual partners ( 30643258) Perceived intensity of sweet substances ( 31005972) Red blood cell count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 28991256 29483656) Smoking status (ever vs never smokers) ( 30643258) Squamous cell lung carcinoma ( 28604730)	Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Aging (time to event) ( 21782286) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Attention deficit hyperactivity disorder ( 29325848) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) General cognitive ability ( 29844566) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Left-handedness ( 32989287) Monocyte percentage of white cells ( 32888494) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Refractive error ( 32231278) Schizophrenia ( 28991256) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		6 interacting genes: H3C1 H4C1 RB1 RNF168 RNF8 RSPH1	5 interacting genes: ACTG1 RPL8 SCAMP2 TTR ZBTB5
Entrez ID		9682	6487
HPRD ID		17168	05930
Ensembl ID		ENSG00000066135	ENSG00000126091
Uniprot IDs		O75164	A0A2R8Y6H4 A0A2R8Y6L4 A0A2R8Y732 A0A2R8YDJ6 Q11203
PDB IDs		2GF7 2GFA 2GP3 2GP5 2OQ6 2OQ7 2OS2 2OT7 2OX0 2P5B 2PXJ 2Q8C 2Q8D 2Q8E 2QQR 2QQS 2VD7 2WWJ 2YBK 2YBP 2YBS 3NJY 3PDQ 3RVH 3U4S 4AI9 4BIS 4GD4 4URA 4V2V 4V2W 5A7N 5A7O 5A7P 5A7Q 5A7S 5A7W 5A80 5ANQ 5D6W 5D6X 5D6Y 5F2S 5F2W 5F32 5F37 5F39 5F3C 5F3E 5F3G 5F3I 5F5I 5FPV 5FWE 5FY8 5FYC 5FYH 5FYI 5LY1 5LY2 5TVR 5TVS 5VAR 5VGI 5VMP 6CG1 6CG2 6G5W 6G5X 6H4O 6H4P 6H4Q 6H4R 6H4S 6H4T 6H4U 6H4V 6H4W 6H4X 6H4Y 6H8P 6HGT 7D4A 7EQV 8WD3 9GII 9GLE 9GP1 9GP4
Enriched GO Terms of Interacting Partners?		Protein Localization To Chromosome Chromatin Remodeling Epigenetic Regulation Of Gene Expression Chromosome Organization Chromosome Isotype Switching Somatic Diversification Of Immunoglobulins Involved In Immune Response DNA Repair-dependent Chromatin Remodeling Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Negative Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Transcription Elongation By RNA Polymerase II Cytoplasmic Translational Initiation Somatic Recombination Of Immunoglobulin Gene Segments Attachment Of Spindle Microtubules To Kinetochore Chromatin Organization Protein Localization To Chromosome, Centromeric Region B Cell Activation Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Interstrand Cross-link Repair Translation Initiation Factor Activity Cyanocobalamin Reductase (cyanide-eliminating) (NADP+) Activity Histone H2AK15 Ubiquitin Ligase Activity Double-strand Break Repair Via Nonhomologous End Joining B Cell Activation Involved In Immune Response
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