KDM4A and RNF168

Number of citations of the paper that reports this interaction (PMID 22373579)
50

Data Source:
BioGRID (enzymatic study)

		KDM4A	RNF168
Gene Name		lysine (K)-specific demethylase 4A	ring finger protein 168, E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Site Of Double-strand Break
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Methylated Histone Binding Histone Demethylase Activity (H3-K36 Specific)	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Nucleosome Binding Histone Binding Ubiquitin Binding K63-linked Polyubiquitin Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Cardiac Muscle Hypertrophy In Response To Stress Viral Process Histone Demethylation Negative Regulation Of Transcription, DNA-templated Oxidation-reduction Process Histone H3-K36 Demethylation	Double-strand Break Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2A Monoubiquitination Interstrand Cross-link Repair Histone H2A-K13 Ubiquitination Histone H2A-K15 Ubiquitination Isotype Switching Positive Regulation Of DNA Repair Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination
Pathways		Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs
Diseases
GWAS			Fat distribution (HIV) ( 21897333)
Protein-Protein Interactions		5 interactors: HIST1H3A HIST1H4A RB1 RNF168 RNF8	12 interactors: H2AFX HIST2H2AC JMJD1C KDM4A KIAA0368 LAPTM5 RABGEF1 RNF11 UBC UBE2D3 UBE2E1 UBE2G2
Entrez ID		9682	165918
HPRD ID		17168	08190
Ensembl ID		ENSG00000066135	ENSG00000163961
Uniprot IDs		O75164	Q8IYW5
PDB IDs		2GF7 2GFA 2GP3 2GP5 2OQ6 2OQ7 2OS2 2OT7 2OX0 2P5B 2PXJ 2Q8C 2Q8D 2Q8E 2QQR 2QQS 2VD7 2WWJ 2YBK 2YBP 2YBS 3NJY 3PDQ 3RVH 3U4S 4AI9 4GD4	3L11 4GB0
Enriched GO Terms of Interacting Partners?		Chromatin Organization Histone H2A K63-linked Ubiquitination Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Replication-dependent Nucleosome Assembly Interstrand Cross-link Repair Chromatin Modification Nucleosome Organization DNA Methylation On Cytosine Histone H2A Ubiquitination Chromatin Silencing At RDNA Chromatin Remodeling Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Negative Regulation Of DNA-templated Transcription, Elongation Isotype Switching Protein K63-linked Ubiquitination Histone Exchange DNA Metabolic Process Chromatin Silencing Histone Ubiquitination Somatic Recombination Of Immunoglobulin Gene Segments Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of DNA Repair Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response Histone Modification Organelle Organization Regulation Of DNA-templated Transcription, Elongation DNA Methylation Immunoglobulin Production Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic DNA Modification Gene Silencing Regulation Of Transcription, DNA-templated Histone H2A-K13 Ubiquitination Histone H2A-K15 Ubiquitination Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Immune System Development Nucleosome Assembly	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K48-linked Ubiquitination Protein Polyubiquitination Cellular Macromolecule Catabolic Process Proteolysis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Catabolic Process Negative Regulation Of Cytokine Production ER-associated Ubiquitin-dependent Protein Catabolic Process Cell Cycle Checkpoint Protein Monoubiquitination Negative Regulation Of Type I Interferon Production Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Chromatin Organization Cellular Protein Modification Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Kit Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Protein Ubiquitination Chromosome Organization Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction
Tagcloud ?		1alpha benzoquinone catalytic cbp ch1 coactivators compounds demethylase derivatives ejection electrophilic fragment give hif hypoxia hypoxic indandione inducible interpreting modifying naphthoquinones ninhydrin p300 product reports screen thiol tight zn	53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic plk1 properly recombination rnf8 s1618 spatiotemporally ubiquitinated
Tagcloud (Difference) ?		1alpha benzoquinone catalytic cbp ch1 coactivators compounds demethylase derivatives ejection electrophilic fragment give hif hypoxia hypoxic indandione inducible interpreting modifying naphthoquinones ninhydrin p300 product reports screen thiol tight zn	53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic plk1 properly recombination rnf8 s1618 spatiotemporally ubiquitinated
Tagcloud (Intersection) ?