KDM4A and H4C1

Number of citations: 53 (PubMedID 17190600)
Data Source: BioGRID (unspecified method)

		KDM4A	H4C1
Name		lysine demethylase 4A	H4 clustered histone 1
Structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytosol	Chromosome, Telomeric Region Nucleosome Extracellular Region Nucleus Nucleoplasm Chromosome Membrane Protein-containing Complex CENP-A Containing Nucleosome Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Oxidoreductase Activity Ubiquitin Protein Ligase Binding Histone Demethylase Activity Histone H3K9 Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Histone H4K20me2 Reader Activity Histone H3K36me2/H3K36me3 Demethylase Activity Histone H3K9me2/H3K9me3 Demethylase Activity	DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of Gene Expression Negative Regulation Of Autophagy Negative Regulation Of Gene Expression Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of DNA-templated Transcription	Chromatin Organization Nucleosome Assembly Telomere Organization Negative Regulation Of Megakaryocyte Differentiation Protein Localization To CENP-A Containing Chromatin
Pathways		HDMs demethylate histones Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Household income (MTAG) ( 31844048 ) Menarche (age at onset) ( 25231870 ) Number of sexual partners ( 30643258 ) Perceived intensity of sweet substances ( 31005972 ) Red blood cell count ( 32888494 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 28991256 29483656 ) Smoking status (ever vs never smokers) ( 30643258 ) Squamous cell lung carcinoma ( 28604730 )	No GWAS studies recorded
Interacting Genes		6 interacting genes: H3C1 H4C1 RB1 RNF168 RNF8 RSPH1	85 interacting genes: ANP32A ANP32B ASF1A BAZ2A CBX3 CDK1 CDK2 CEBPA CHD4 COPS2 DPF2 DYRK1A EID1 ELP3 EP300 ERCC6 EXO1 FANCD2 GATAD2A GATAD2B HDAC3 HDAC8 HIRIP3 HJURP JADE1 JMJD6 KAT14 KAT2B KAT5 KAT6A KAT7 KAT8 KDM4A KMT2C KMT2D KMT5A KMT5B KMT5C L3MBTL2 MBTD1 MRE11 MSL2 MSL3 MYB NAA10 NAP1L1 NCOR1 NCOR2 NSD1 NSD3 ORC1 PAK1 PALB2 PARP10 PBRM1 PELP1 PHF1 PHF20 PHF8 PRMT1 PRMT5 PRMT7 PRMT8 PSME4 PTMA RAD23A RBBP7 SETD7 SHPRH SIRT7 SMYD5 SUPT16H TAF1A TAF1B TBL1X THAP7 TLE3 TP53BP1 TRIM24 TRIM28 TRIM29 TSPYL5 UCHL5 WBP2 ZMYND11
Entrez ID		9682	8359
HPRD ID		17168	04157
Ensembl ID		ENSG00000066135	ENSG00000278637
Uniprot IDs		O75164	P62805
PDB IDs		2GF7 2GFA 2GP3 2GP5 2OQ6 2OQ7 2OS2 2OT7 2OX0 2P5B 2PXJ 2Q8C 2Q8D 2Q8E 2QQR 2QQS 2VD7 2WWJ 2YBK 2YBP 2YBS 3NJY 3PDQ 3RVH 3U4S 4AI9 4BIS 4GD4 4URA 4V2V 4V2W 5A7N 5A7O 5A7P 5A7Q 5A7S 5A7W 5A80 5ANQ 5D6W 5D6X 5D6Y 5F2S 5F2W 5F32 5F37 5F39 5F3C 5F3E 5F3G 5F3I 5F5I 5FPV 5FWE 5FY8 5FYC 5FYH 5FYI 5LY1 5LY2 5TVR 5TVS 5VAR 5VGI 5VMP 6CG1 6CG2 6G5W 6G5X 6H4O 6H4P 6H4Q 6H4R 6H4S 6H4T 6H4U 6H4V 6H4W 6H4X 6H4Y 6H8P 6HGT 7D4A 7EQV 8WD3 9GII 9GLE 9GP1 9GP4	1ZKK 2BQZ 2CV5 2IG0 2KWN 2KWO 2LVM 2QQS 2RJE 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3IJ1 3JPX 3NQJ 3NQU 3O36 3QBY 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 3WA9 3WAA 3WKJ 3WTP 3X1S 3X1T 3X1U 3X1V 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4M38 4N3W 4N4F 4QUT 4QUU 4QYD 4U9W 4YM5 4YM6 4YY6 4YYD 4YYG 4YYH 4YYI 4YYJ 4YYK 4YYM 4YYN 4Z2M 4Z5T 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5AY8 5B0Y 5B0Z 5B24 5B2I 5B2J 5B31 5B32 5B33 5B40 5BNV 5BNX 5BO0 5C3I 5CPI 5CPJ 5CPK 5FA5 5FFW 5FWE 5GSE 5GSU 5GT0 5GT3 5GTC 5GXQ 5JA4 5JRG 5KDM 5TEG 5X7X 5XF3 5XF4 5XF5 5Y0C 5Y0D 5YE3 5YE4 5Z23 5Z30 5ZBX 5ZGC 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6ACP 6BUZ 6C0W 6E0C 6E0P 6FML 6HKT 6HTS 6INQ 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6JOU 6JR0 6JR1 6K1I 6K1J 6K1K 6KE9 6KVD 6KXV 6L49 6L4A 6L9H 6L9Z 6LA2 6LA8 6LA9 6LAB 6LE9 6LER 6M3V 6M44 6M4D 6M4G 6M4H 6MLC 6MUO 6MUP 6O1D 6R0C 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6RNY 6RXS 6SE0 6SE6 6SEE 6SEF 6SEG 6T79 6T7A 6T7B 6T7C 6T7D 6T90 6T93 6UPK 6UPL 6USJ 6V2K 6V92 6VO5 6X59 6X5A 6XJD 6Y5D 6YOV 7A08 7BWD 7BXT 7BY0 7C0M 7CCQ 7CCR 7CIZ 7CJ0 7COW 7D1Z 7D20 7DBP 7E8D 7EIC 7EID 7JO9 7JOA 7JZV 7K5X 7K5Y 7K60 7K61 7K63 7LMK 7LMM 7LYA 7LYB 7LYC 7M98 7NL0 7PET 7PEU 7PEV 7PEW 7PEX 7PEY 7PEZ 7PF0 7PF2 7PF3 7PF4 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFF 7PFT 7PFU 7PFV 7PFW 7PFX 7PII 7R5R 7SCY 7SCZ 7TAN 7U0G 7U0I 7U0J 7U46 7U47 7U4D 7U50 7U51 7U52 7U53 7UV9 7V1M 7V6Q 7V90 7V96 7V9C 7V9J 7V9K 7V9S 7VA4 7VCQ 7VZ4 7W9V 7WBV 7WBW 7WBX 7X57 7X58 7XCR 7XCT 7XD0 7XD1 7XSE 7XSX 7XSZ 7XT7 7XTD 7XTI 7XVL 7XVM 7XX5 7XX6 7XZX 7XZY 7XZZ 7Y00 7Y5U 7Y5V 7Y5W 7Y60 7Y61 7Y7I 7Y8R 7YOZ 7YQK 7YRD 7YWX 7YYH 7ZI4 8AAG 8ATF 8AV6 8B5A 8B5B 8B5C 8DK5 8EVG 8EVH 8EVI 8EVJ 8GRM 8GRQ 8GUI 8GUJ 8GUK 8H0V 8H0W 8H1T 8HAG 8HAH 8HAI 8HAJ 8HAK 8HAL 8HAM 8HAN 8HE5 8HLW 8HR1 8IEG 8IEJ 8IHL 8IQF 8IQG 8J6S 8J6T 8JBX 8JCC 8JCD 8JH2 8JH3 8JH4 8JHF 8JHG 8JL9 8JLA 8JLB 8JLD 8JND 8JNE 8JNF 8KB5 8KCY 8KD1 8KE0 8OFF 8OL1 8OO7 8OOA 8OOP 8OOS 8OSJ 8OSK 8OSL 8OTS 8OTT 8OX0 8OX1 8PEF 8Q36 8Q3E 8Q3M 8Q3X 8QZM 8RBX 8RGM 8SB6 8SDO 8SDQ 8SDX 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8SPS 8SPU 8SYP 8TGP 8TXV 8TXW 8TXX 8U13 8U14 8UHL 8UK5 8UPF 8VFX 8VFY 8VFZ 8VG0 8VG1 8VG2 8VLR 8VMJ 8VMN 8VOB 8VWS 8VWT 8VWU 8VWV 8W9D 8W9E 8W9F 8WG5 8X15 8X19 8X1C 8X7I 8X7J 8X7K 8XBT 8XBU 8XBW 8Y3C 8Y3D 8Y3E 8Y3F 8YBJ 8YBK 8YJF 8YJM 8YNY 8YTI 8YV8 8Z50 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM 9EOZ 9FGQ 9FH9 9GMK 9GMR 9GXA 9IPU 9J0N 9J0O 9J0P 9J8M 9J8N 9J8O
GO Terms Enriched among Interactors		Protein Localization To Chromosome Chromatin Remodeling Epigenetic Regulation Of Gene Expression Chromosome Organization Chromosome Isotype Switching Somatic Diversification Of Immunoglobulins Involved In Immune Response DNA Repair-dependent Chromatin Remodeling Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Negative Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Transcription Elongation By RNA Polymerase II Cytoplasmic Translational Initiation Somatic Recombination Of Immunoglobulin Gene Segments Attachment Of Spindle Microtubules To Kinetochore Chromatin Organization Protein Localization To Chromosome, Centromeric Region B Cell Activation Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Interstrand Cross-link Repair Translation Initiation Factor Activity Cyanocobalamin Reductase (cyanide-eliminating) (NADP+) Activity Histone H2AK15 Ubiquitin Ligase Activity Double-strand Break Repair Via Nonhomologous End Joining B Cell Activation Involved In Immune Response	Chromatin Organization Chromatin Remodeling Nucleoplasm Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Chromosome Negative Regulation Of RNA Biosynthetic Process DNA Repair Negative Regulation Of RNA Metabolic Process DNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Response To Stress Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Histone Methyltransferase Activity Regulation Of DNA Repair Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Histone Binding Positive Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of DNA Metabolic Process Epigenetic Regulation Of Gene Expression Positive Regulation Of Metabolic Process Histone H4 Methyltransferase Activity Transcription Corepressor Activity Methyltransferase Activity Acetyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA Metabolic Process