KDM4A and HIST1H4A

Number of citations of the paper that reports this interaction (PMID 17190600)
231

Data Source:
BioGRID (unspecified method)

		KDM4A	HIST1H4A
Gene Name		lysine (K)-specific demethylase 4A	histone cluster 1, H4a
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Methylated Histone Binding Histone Demethylase Activity (H3-K36 Specific)	DNA Binding Protein Binding Histone Demethylase Activity (H4-K20 Specific) Poly(A) RNA Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Organization Transcription, DNA-templated Cardiac Muscle Hypertrophy In Response To Stress Viral Process Histone Demethylation Negative Regulation Of Transcription, DNA-templated Oxidation-reduction Process Histone H3-K36 Demethylation	Chromatin Silencing At RDNA Mitotic Cell Cycle Telomere Maintenance Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Gene Expression DNA Methylation On Cytosine CENP-A Containing Nucleosome Assembly Histone H4-K20 Demethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic
Pathways		Chromatin modifying enzymes Chromatin organization HDMs demethylate histones	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS			HIV-1 viral setpoint ( 22174851)
Protein-Protein Interactions		5 interactors: HIST1H3A HIST1H4A RB1 RNF168 RNF8	73 interactors: ANP32A BAZ1B BAZ2A BLOC1S1 BRD2 CALCOCO1 CBX3 CDK1 CDK2 COPS2 CREBBP CTDP1 DYRK1A EID1 ELP3 EP300 ERCC6 GATAD2A GATAD2B HAT1 HDAC1 HDAC2 HDAC3 HDAC8 HIRIP3 HIST1H3A HIST2H2AC HIST2H2BE HJURP KAT2A KAT2B KAT5 KAT6A KAT7 KAT8 KDM4A KMT2A L3MBTL2 MSL2 MSL3 NASP NCOR1 NCOR2 NPM1 NR1H4 PAK1 PARP1 PARP10 PBRM1 PELP1 PHF20 PHF8 PRMT1 PRMT5 PRMT7 PRMT8 PTMA RCC1 SETD7 SIRT7 SSRP1 SUV420H1 SUV420H2 TAF1 TAF1A TAF1B TBL1X THAP7 TP53BP1 UBC UBE2I UCHL5 YY1
Entrez ID		9682	8359
HPRD ID		17168	04157
Ensembl ID		ENSG00000066135	ENSG00000196176
Uniprot IDs		O75164	B2R4R0 P62805
PDB IDs		2GF7 2GFA 2GP3 2GP5 2OQ6 2OQ7 2OS2 2OT7 2OX0 2P5B 2PXJ 2Q8C 2Q8D 2Q8E 2QQR 2QQS 2VD7 2WWJ 2YBK 2YBP 2YBS 3NJY 3PDQ 3RVH 3U4S 4AI9 4GD4	2BQZ 2CV5 2KWN 2KWO 2LVM 2QQS 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3NQJ 3NQU 3O36 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA
Enriched GO Terms of Interacting Partners?		Chromatin Organization Histone H2A K63-linked Ubiquitination Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Replication-dependent Nucleosome Assembly Interstrand Cross-link Repair Chromatin Modification Nucleosome Organization DNA Methylation On Cytosine Histone H2A Ubiquitination Chromatin Silencing At RDNA Chromatin Remodeling Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Negative Regulation Of DNA-templated Transcription, Elongation Isotype Switching Protein K63-linked Ubiquitination Histone Exchange DNA Metabolic Process Chromatin Silencing Histone Ubiquitination Somatic Recombination Of Immunoglobulin Gene Segments Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of DNA Repair Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response Histone Modification Organelle Organization Regulation Of DNA-templated Transcription, Elongation DNA Methylation Immunoglobulin Production Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic DNA Modification Gene Silencing Regulation Of Transcription, DNA-templated Histone H2A-K13 Ubiquitination Histone H2A-K15 Ubiquitination Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Immune System Development Nucleosome Assembly	Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Regulation Of Metabolic Process Peptidyl-lysine Acetylation Peptidyl-amino Acid Modification Protein Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Histone Acetylation Negative Regulation Of RNA Biosynthetic Process Internal Peptidyl-lysine Acetylation Cellular Protein Modification Process Internal Protein Amino Acid Acetylation Negative Regulation Of Gene Expression Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Histone H4 Acetylation Cellular Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Chromatin Remodeling Chromatin Assembly Or Disassembly Regulation Of Cellular Process Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter
Tagcloud ?		1alpha benzoquinone catalytic cbp ch1 coactivators compounds demethylase derivatives ejection electrophilic fragment give hif hypoxia hypoxic indandione inducible interpreting modifying naphthoquinones ninhydrin p300 product reports screen thiol tight zn
Tagcloud (Difference) ?		1alpha benzoquinone catalytic cbp ch1 coactivators compounds demethylase derivatives ejection electrophilic fragment give hif hypoxia hypoxic indandione inducible interpreting modifying naphthoquinones ninhydrin p300 product reports screen thiol tight zn
Tagcloud (Intersection) ?