BTRC and CHUK

Number of citations of the paper that reports this interaction (PMID 12504025)
93

Data Source:
BioGRID (enzymatic study)

		BTRC	CHUK
Gene Name		beta-transducin repeat containing E3 ubiquitin protein ligase	conserved helix-loop-helix ubiquitous kinase
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex	Nucleoplasm Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Ligase Activity Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity	Protein Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Homodimerization Activity Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Signal Transduction Circadian Rhythm Viral Process Wnt Signaling Pathway Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cell Cycle Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Organic Cyclic Compound	Morphogenesis Of An Epithelial Sheet Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Skeletal Muscle Contraction Protein Phosphorylation Inflammatory Response Immune Response Epidermal Growth Factor Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Rho Protein Signal Transduction Lactation Fibroblast Growth Factor Receptor Signaling Pathway Response To Virus Response To Toxic Substance Anatomical Structure Morphogenesis Osteoclast Differentiation Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Response To Hydroperoxide Mammary Gland Epithelial Cell Proliferation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Odontogenesis Of Dentin-containing Tooth Response To Drug Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Mammary Gland Alveolus Development Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Tumor Necrosis Factor
Pathways		Signaling by the B Cell Receptor (BCR) Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt Regulation of PLK1 Activity at G2/M Transition Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation Prolactin receptor signaling truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Host Interactions of HIV factors AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Signaling by Interleukins deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Interleukin-1 signaling Mitotic G2-G2/M phases Adaptive Immune System Antigen processing: Ubiquitination & Proteasome degradation APC truncation mutants have impaired AXIN binding HIV Infection G2/M Transition deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN Class I MHC mediated antigen processing & presentation Vpu mediated degradation of CD4 Cytokine Signaling in Immune system Cell Cycle, Mitotic Nuclear signaling by ERBB4 TCF dependent signaling in response to WNT Activation of NF-kappaB in B cells SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by Hedgehog Degradation of GLI1 by the proteasome Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol RIP-mediated NFkB activation via ZBP1 IRAK1 recruits IKK complex Signaling by SCF-KIT Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) FCERI mediated NF-kB activation PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade PI-3K cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex Signaling by PDGF DAP12 interactions GAB1 signalosome TRIF-mediated TLR3/TLR4 signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins TCR signaling Downstream signal transduction Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling PI3K/AKT Signaling in Cancer TAK1 activates NFkB by phosphorylation and activation of IKKs complex Adaptive Immune System Downstream TCR signaling PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs PI3K events in ERBB2 signaling Downstream signaling of activated FGFR TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Innate Immune System Signalling by NGF IKK complex recruitment mediated by RIP1 Cytosolic sensors of pathogen-associated DNA Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Signaling by FGFR RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Activation of NF-kappaB in B cells TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS			Liver enzyme levels ( 18940312)
Protein-Protein Interactions		72 interactors: AGO2 AMER1 ATF4 AXIN1 BHLHE40 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CHPF CHUK CP CTNNB1 CUL1 DBN1 DEPTOR DLGAP5 E2F1 FBXO5 FBXW11 FOXO3 GH1 GHR GLI3 GSK3B HIPK2 HNRNPC HNRNPK HNRNPU ICE1 JUP KDR MDM2 MYB MYC NFE2 NFKB1 NFKB2 NFKBIA NFKBIB PCDH8 PDCD4 PRDX1 PSMA3 PSMD4 RASSF5 RCAN1 RELA SKP1 SMAD3 SMAD4 SMURF2 SP1 SUFU TACC1 TAZ TFAP4 TIAM1 TP63 TRIM9 TSPAN15 UBE2D2 UBE2D3 UBE2R2 UBQLN2 UHRF1 USP37 WEE1 YAP1 ZC3H12A	75 interactors: AKT1 AKT2 BCL10 BTRC CASP8 CDC37 CHEK1 COPS5 CREBBP CSF2RA CSNK2A1 CTNNB1 CUEDC2 CUL1 EIF2AK2 ERBB2IP ESR1 FKBP5 FOXO3 HIST2H3C HIST3H3 HSP90AA1 HSP90AB1 HTT IKBKAP IKBKB IKBKE IKBKG IRS1 MAP3K1 MAP3K11 MAP3K14 MAP3K4 MAP3K7 MAP3K8 NCOA3 NCOR1 NCOR2 NFKB1 NFKB2 NFKBIA NFKBIB NLRP4 NOTCH3 NR2C2 PAX8 PEBP1 PIAS1 PRKCB PRKCI PRKCQ PRKDC PTPN11 RELA RICTOR RIPK2 RPL27 SRC SRPK1 SRPK2 STAP2 TANK TGFBR1 TNFAIP3 TNFRSF1A TNIP2 TP53 TRAF2 TRAF3IP2 TRAF4 TRIM27 TRPC4AP UBE2E3 UBE2I UBE2N
Entrez ID		8945	1147
HPRD ID		04596	02811
Ensembl ID		ENSG00000166167	ENSG00000213341
Uniprot IDs		B2R8L3 B7Z3H4 Q68DS0 Q9Y297	O15111
PDB IDs		1P22 2P64	3BRT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Response To Growth Factor Cell Communication G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Signaling Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Intracellular Signal Transduction Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Regulation Of Signaling Programmed Cell Death Regulation Of Transcription, DNA-templated Cell Death Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Cellular Response To Stimulus Cell Cycle Process Regulation Of Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus	Innate Immune Response Immune Response Immune Response-regulating Signaling Pathway Signal Transduction Positive Regulation Of Cellular Metabolic Process Immune System Process Signaling Defense Response Positive Regulation Of Metabolic Process Cell Communication Regulation Of Signal Transduction Regulation Of Innate Immune Response Cellular Response To Organic Substance Regulation Of Signaling Regulation Of Immune Response Regulation Of Immune System Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction Intracellular Signal Transduction Activation Of Innate Immune Response Cellular Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Toll-like Receptor 3 Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Death Death Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Programmed Cell Death Regulation Of Metabolic Process Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Modification Process MyD88-independent Toll-like Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Response To Stress
Tagcloud ?		aggregate austere bias biases chamber clinics error homes humidity individually instruments isolate meter meters minutes poc rank reagent responders signed spiked static stressed stresses strip strips tenney unstressed wilcoxon	accentuated analog analogs antineoplastic attributes coincided confined correspond cyclooxygenase encountered govern implying instance krox microtubule modulates oligoadenylate oncology originate prompts questions simply stabilization taxane taxol taxotere termed traits unidentified
Tagcloud (Difference) ?		aggregate austere bias biases chamber clinics error homes humidity individually instruments isolate meter meters minutes poc rank reagent responders signed spiked static stressed stresses strip strips tenney unstressed wilcoxon	accentuated analog analogs antineoplastic attributes coincided confined correspond cyclooxygenase encountered govern implying instance krox microtubule modulates oligoadenylate oncology originate prompts questions simply stabilization taxane taxol taxotere termed traits unidentified
Tagcloud (Intersection) ?