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BTRC and CHUK
Number of citations of the paper that reports this interaction (PubMedID
12504025
)
0
Data Source:
BioGRID
(enzymatic study)
BTRC
CHUK
Description
beta-transducin repeat containing E3 ubiquitin protein ligase
component of inhibitor of nuclear factor kappa B kinase complex
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
SCF Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Molecular Function
Protein Binding
Beta-catenin Binding
Ligase Activity
Protein Phosphorylated Amino Acid Binding
Protein Dimerization Activity
Ubiquitin Protein Ligase Activity
Ubiquitin-like Ligase-substrate Adaptor Activity
Ubiquitin Ligase Activator Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Kinase Activity
Transferase Activity
Protein Homodimerization Activity
Protein-containing Complex Binding
Protein Heterodimerization Activity
Scaffold Protein Binding
Transferrin Receptor Binding
Biological Process
Autophagosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Protein Dephosphorylation
Ubiquitin-dependent Protein Catabolic Process
Lysosome Organization
Signal Transduction
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Wnt Signaling Pathway
Protein Ubiquitination
Protein Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Destabilization
Cellular Response To Nutrient Levels
Mammary Gland Epithelial Cell Proliferation
Non-canonical NF-kappaB Signal Transduction
TORC1 Signaling
Regulation Of Circadian Rhythm
Positive Regulation Of Circadian Rhythm
Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis
Negative Regulation Of Smoothened Signaling Pathway
Positive Regulation Of DNA-templated Transcription
Rhythmic Process
T Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Regulation Of Cell Cycle
Branching Involved In Mammary Gland Duct Morphogenesis
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Negative Regulation Of TORC1 Signaling
Pattern Recognition Receptor Signaling Pathway
Skeletal Muscle Contraction
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Immune Response
Canonical NF-kappaB Signal Transduction
Response To Xenobiotic Stimulus
Response To Virus
Response To Toxic Substance
Anatomical Structure Morphogenesis
Response To Acetate
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Interferon-alpha Production
Response To Hydroperoxide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Amino Acid
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of NF-kappaB Transcription Factor Activity
Striated Muscle Cell Differentiation
Response To Cholecystokinin
Cellular Response To Tumor Necrosis Factor
Cellular Response To Virus
Pathways
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Deactivation of the beta-catenin transactivating complex
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Neddylation
Interleukin-1 signaling
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Antigen processing: Ubiquitination & Proteasome degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
AKT phosphorylates targets in the cytosol
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Constitutive Signaling by AKT1 E17K in Cancer
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
Drugs
Aminosalicylic acid
Mesalazine
Acetylcysteine
Diseases
Cocoon syndrome
GWAS
Diastolic blood pressure (
30224653
)
Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) (
33987465
)
Red blood cell count (
29403010
)
Red cell distribution width (
32888494
)
Smoking initiation (
33082346
)
Smoking status (ever vs never smokers) (
30643258
)
Walking pace (
33128006
)
Liver enzyme levels (
18940312
)
Psoriasis (
28537254
)
Psoriasis or type 2 diabetes (trans-disease meta-analysis) (
33385400
)
Type 2 diabetes (
30054458
)
Interacting Genes
94 interacting genes:
AGO2
AKT1
AMER1
ATF4
AXIN1
AXIN2
BORA
CCND1
CCNE1
CDC25A
CDC34
CDK1
CENPW
CHPF
CHUK
CP
CRYAA
CTNNB1
CUL1
DBN1
DLGAP5
E2F1
FBXW11
FBXW2
FOXO3
FZR1
GHR
GLI2
GLI3
GSK3B
HERC3
HIPK2
HNRNPU
ICE1
IKBKB
IL10RA
JUP
KDR
KEAP1
KMT5A
LINC00511
LPCAT1
MAPK1
MAPK13
MAPK14
MAPK6
MAPK9
MCL1
MDM2
MITF
MYB
NFE2
NFE2L2
NFKB1
NFKB2
NFKBIA
NFKBIB
NHSL2
PAQR3
PCDH8
PDCD4
PHF19
PLK4
PSMA3
PSMD4
RASSF5
RCAN1
RELA
RIPK4
RNF7
SKP1
SLC7A11-AS1
SMAD3
SMAD4
SMURF1
SMURF2
SUFU
TACC1
TAFAZZIN
TFE3
TIAM1
TP63
TRIB2
TRIM36
TRIM9
TSPAN15
UBC
UBE2D2
UBE2R2
UBQLN2
WEE1
WWTR1
XRCC1
ZC3H12A
85 interacting genes:
AKT1
AKT2
AMBRA1
ATM
ATR
BCL10
BCL3
BTRC
CASP8
CDC37
CHEK1
CREBBP
CSF2RA
CSNK2A1
CTNNB1
CUEDC2
CUL1
DCUN1D5
E2F4
EIF2AK2
ELP1
ERBIN
ESR1
FKBP5
FOXO3
H3-4
H3C1
H3C14
HECTD3
HSP90AA1
HSP90AB1
HTT
IKBKB
IKBKE
IKBKG
IRS1
MAP3K1
MAP3K11
MAP3K14
MAP3K4
MAP3K7
MAP3K8
MYC
NCOA3
NCOR1
NCOR2
NFKB1
NFKB2
NFKBIA
NFKBIB
NLRP4
NOTCH3
NR2C2
PAX8
PEBP1
PIAS1
PRKCB
PRKCI
PRKCQ
PRKDC
PTPN11
RELA
RICTOR
RIPK2
RPL27
SAMHD1
SRC
SRPK1
SRPK2
STAP2
TANK
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TRAF2
TRAF3IP2
TRAF4
TRIM27
TRPC4AP
TTC3
UBC
UBE2E3
UBE2I
UBE2N
Entrez ID
8945
1147
HPRD ID
04596
02811
Ensembl ID
ENSG00000166167
ENSG00000213341
Uniprot IDs
A0A0S2Z4P6
B2R8L3
B7Z3H4
Q9Y297
O15111
PDB IDs
1P22
2P64
6M90
6M91
6M92
6M93
6M94
6TTU
3BRT
5EBZ
5TQW
5TQX
5TQY
Enriched GO Terms of Interacting Partners
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Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Differentiation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cytosol
Protein Catabolic Process
Nucleus
Positive Regulation Of Developmental Process
Positive Regulation Of Macromolecule Metabolic Process
Macromolecule Catabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Developmental Process
Nucleoplasm
Cytoplasm
Protein Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Proteolysis
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cell Differentiation
Cell Surface Receptor Signaling Pathway
Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Signal Transduction
Regulation Of Protein Catabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Protein Metabolic Process
Protein Modification Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Proteolysis
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Protein Catabolic Process
Regulation Of Multicellular Organismal Development
Response To Oxidative Stress
Negative Regulation Of Cell Differentiation
Protein Ubiquitination
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Catabolic Process
Macromolecule Metabolic Process
Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Cytosol
Nucleoplasm
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Communication
Ubiquitin Protein Ligase Binding
Negative Regulation Of Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Non-canonical NF-kappaB Signal Transduction
Regulation Of Primary Metabolic Process
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Protein Kinase Activity
Regulation Of Apoptotic Process
Protein Modification Process
Protein Serine Kinase Activity
Immune System Process
Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Immune System Process
Regulation Of Immune Response
Nucleus
Transferase Activity
Protein Metabolic Process
Kinase Activity
Regulation Of Innate Immune Response
Intracellular Signaling Cassette
Cytoplasm
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Stress
Cellular Response To Stress
Regulation Of Nucleobase-containing Compound Metabolic Process
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