BTRC and RCAN1

Number of citations of the paper that reports this interaction (PMID 18575781)
4

Data Source:
BioGRID (enzymatic study)

		BTRC	RCAN1
Gene Name		beta-transducin repeat containing E3 ubiquitin protein ligase	regulator of calcineurin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex	Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Ligase Activity Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Identical Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Signal Transduction Circadian Rhythm Viral Process Wnt Signaling Pathway Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cell Cycle Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Organic Cyclic Compound	Regulation Of Transcription, DNA-templated Signal Transduction Central Nervous System Development Blood Circulation Calcium-mediated Signaling
Pathways		Signaling by the B Cell Receptor (BCR) Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt Regulation of PLK1 Activity at G2/M Transition Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation Prolactin receptor signaling truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Host Interactions of HIV factors AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Signaling by Interleukins deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Interleukin-1 signaling Mitotic G2-G2/M phases Adaptive Immune System Antigen processing: Ubiquitination & Proteasome degradation APC truncation mutants have impaired AXIN binding HIV Infection G2/M Transition deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN Class I MHC mediated antigen processing & presentation Vpu mediated degradation of CD4 Cytokine Signaling in Immune system Cell Cycle, Mitotic Nuclear signaling by ERBB4 TCF dependent signaling in response to WNT Activation of NF-kappaB in B cells SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by Hedgehog Degradation of GLI1 by the proteasome Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS
Protein-Protein Interactions		72 interactors: AGO2 AMER1 ATF4 AXIN1 BHLHE40 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CHPF CHUK CP CTNNB1 CUL1 DBN1 DEPTOR DLGAP5 E2F1 FBXO5 FBXW11 FOXO3 GH1 GHR GLI3 GSK3B HIPK2 HNRNPC HNRNPK HNRNPU ICE1 JUP KDR MDM2 MYB MYC NFE2 NFKB1 NFKB2 NFKBIA NFKBIB PCDH8 PDCD4 PRDX1 PSMA3 PSMD4 RASSF5 RCAN1 RELA SKP1 SMAD3 SMAD4 SMURF2 SP1 SUFU TACC1 TAZ TFAP4 TIAM1 TP63 TRIM9 TSPAN15 UBE2D2 UBE2D3 UBE2R2 UBQLN2 UHRF1 USP37 WEE1 YAP1 ZC3H12A	7 interactors: APP BTRC GSK3B MAP3K3 MAPK3 PPP3CA UXT
Entrez ID		8945	1827
HPRD ID		04596	04226
Ensembl ID		ENSG00000166167	ENSG00000159200
Uniprot IDs		B2R8L3 B7Z3H4 Q68DS0 Q9Y297	P53805 Q6FGP2
PDB IDs		1P22 2P64
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Response To Growth Factor Cell Communication G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Signaling Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Intracellular Signal Transduction Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Regulation Of Signaling Programmed Cell Death Regulation Of Transcription, DNA-templated Cell Death Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Cellular Response To Stimulus Cell Cycle Process Regulation Of Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus	Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cardiac Muscle Hypertrophy Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Signaling Regulation Of Cellular Response To Heat Cellular Protein Modification Process Regulation Of Kinase Activity Regulation Of Binding Innate Immune Response Fc Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of MAP Kinase Activity Positive Regulation Of Proteolysis Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Myotube Differentiation Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Heat Activation Of MAPKK Activity System Development Regulation Of Catalytic Activity Cellular Response To Mechanical Stimulus Regulation Of Intracellular Transport Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Immune Response-regulating Signaling Pathway Regulation Of RNA Metabolic Process Immune Response Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Transcription Factor Import Into Nucleus
Tagcloud ?		aggregate austere bias biases chamber clinics error homes humidity individually instruments isolate meter meters minutes poc rank reagent responders signed spiked static stressed stresses strip strips tenney unstressed wilcoxon	actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation flna heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rearrangement regulators shrna underlie upstream ventricles
Tagcloud (Difference) ?		aggregate austere bias biases chamber clinics error homes humidity individually instruments isolate meter meters minutes poc rank reagent responders signed spiked static stressed stresses strip strips tenney unstressed wilcoxon	actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation flna heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rearrangement regulators shrna underlie upstream ventricles
Tagcloud (Intersection) ?