BTRC and HERC3

Number of citations: 45 (PubMedID 36598329)
Data Source: BioGRID (affinity chromatography technology, pull down)

		BTRC	HERC3
Name		beta-transducin repeat containing E3 ubiquitin protein ligase	HECT and RLD domain containing E3 ubiquitin protein ligase 3
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Cytoplasm Cytoplasmic Vesicle
	Molecular Function	Protein Binding Beta-catenin Binding Ligase Activity Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Autophagosome Assembly Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Lysosome Organization Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Autophagy Wnt Signaling Pathway Protein Ubiquitination Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels Mammary Gland Epithelial Cell Proliferation Non-canonical NF-kappaB Signal Transduction TORC1 Signaling Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Rhythmic Process T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Cell Cycle Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of TORC1 Signaling	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Neddylation Interleukin-1 signaling GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins	Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Diastolic blood pressure ( 30224653 ) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465 ) Red blood cell count ( 29403010 ) Red cell distribution width ( 32888494 ) Smoking initiation ( 33082346 ) Smoking status (ever vs never smokers) ( 30643258 ) Walking pace ( 33128006 )	A body shape index ( 34021172 ) Hair greying ( 26926045 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		94 interacting genes: AGO2 AKT1 AMER1 ATF4 AXIN1 AXIN2 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CENPW CHPF CHUK CP CRYAA CTNNB1 CUL1 DBN1 DLGAP5 E2F1 FBXW11 FBXW2 FOXO3 FZR1 GHR GLI2 GLI3 GSK3B HERC3 HIPK2 HNRNPU ICE1 IKBKB IL10RA JUP KDR KEAP1 KMT5A LINC00511 LPCAT1 MAPK1 MAPK13 MAPK14 MAPK6 MAPK9 MCL1 MDM2 MITF MYB NFE2 NFE2L2 NFKB1 NFKB2 NFKBIA NFKBIB NHSL2 PAQR3 PCDH8 PDCD4 PHF19 PLK4 PSMA3 PSMD4 RASSF5 RCAN1 RELA RIPK4 RNF7 SKP1 SLC7A11-AS1 SMAD3 SMAD4 SMURF1 SMURF2 SUFU TACC1 TAFAZZIN TFE3 TIAM1 TP63 TRIB2 TRIM36 TRIM9 TSPAN15 UBC UBE2D2 UBE2R2 UBQLN2 WEE1 WWTR1 XRCC1 ZC3H12A	17 interacting genes: BTRC CCL22 CD33 EIF5A2 HERC6 MAPK1 NME2 RPL23A SRPK2 TK1 TRIM14 UBA52 UBC UBE2D1 UBE2L3 UBQLN1 UBQLN2
Entrez ID		8945	8916
HPRD ID		04596	16093
Ensembl ID		ENSG00000166167	ENSG00000138641
Uniprot IDs		A0A0S2Z4P6 B2R8L3 B7Z3H4 Q9Y297	B4DK41 H0Y8G9 Q15034
PDB IDs		1P22 2P64 6M90 6M91 6M92 6M93 6M94 6TTU	Not available
GO Terms Enriched among Interactors		Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Cytosol Protein Catabolic Process Nucleus Positive Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Developmental Process Nucleoplasm Cytoplasm Protein Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Protein Modification Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Catabolic Process Regulation Of Multicellular Organismal Development Response To Oxidative Stress Negative Regulation Of Cell Differentiation Protein Ubiquitination Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Catabolic Process Macromolecule Metabolic Process	Modification-dependent Protein Catabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Proteolysis Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cytosol Protein Modification By Small Protein Conjugation Pyrimidine-containing Compound Metabolic Process Cytoplasm Protein Tag Activity Mammary Gland Epithelial Cell Proliferation Autophagosome Assembly Autophagosome Organization Positive Regulation Of ERAD Pathway Positive Regulation Of Protein Ubiquitination Nucleus Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of ERAD Pathway Ubiquitin Protein Ligase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Metabolic Process Vacuole Organization Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Pyrimidine-containing Compound Biosynthetic Process Transferase Activity Regulation Of Protein Ubiquitination Mitochondrial Outer Membrane Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Proteasomal Protein Catabolic Process Cytosolic Large Ribosomal Subunit ATP Binding ITP Biosynthetic Process Protein Histidine Kinase Activity Cytosine Metabolic Process Cellular Response To Nutrient Levels Thymidine Kinase Activity Negative Regulation Of TORC1 Signaling