BTRC and PAQR3

Number of citations of the paper that reports this interaction (PubMedID 26905590)
0

Data Source:
BioGRID (pull down)

		BTRC	PAQR3
Description		beta-transducin repeat containing E3 ubiquitin protein ligase	progestin and adipoQ receptor family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Protein Binding Beta-catenin Binding Ligase Activity Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	Protein Binding Protein-membrane Adaptor Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Autophagosome Assembly Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Lysosome Organization Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Autophagy Wnt Signaling Pathway Protein Ubiquitination Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels Mammary Gland Epithelial Cell Proliferation Non-canonical NF-kappaB Signal Transduction TORC1 Signaling Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Rhythmic Process T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Cell Cycle Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of TORC1 Signaling	Negative Regulation Of Protein Phosphorylation NLS-bearing Protein Import Into Nucleus Negative Regulation Of Neuron Projection Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Peptidyl-serine Phosphorylation Protein Localization To Golgi Apparatus Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Positive Regulation Of Cholesterol Biosynthetic Process Protein Maturation Positive Regulation Of SREBP Signaling Pathway
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Neddylation Interleukin-1 signaling GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins	Negative regulation of MAPK pathway
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Walking pace ( 33128006)	Chronotype ( 30696823) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Parkinson's disease ( 26227905)
Interacting Genes		94 interacting genes: AGO2 AKT1 AMER1 ATF4 AXIN1 AXIN2 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CENPW CHPF CHUK CP CRYAA CTNNB1 CUL1 DBN1 DLGAP5 E2F1 FBXW11 FBXW2 FOXO3 FZR1 GHR GLI2 GLI3 GSK3B HERC3 HIPK2 HNRNPU ICE1 IKBKB IL10RA JUP KDR KEAP1 KMT5A LINC00511 LPCAT1 MAPK1 MAPK13 MAPK14 MAPK6 MAPK9 MCL1 MDM2 MITF MYB NFE2 NFE2L2 NFKB1 NFKB2 NFKBIA NFKBIB NHSL2 PAQR3 PCDH8 PDCD4 PHF19 PLK4 PSMA3 PSMD4 RASSF5 RCAN1 RELA RIPK4 RNF7 SKP1 SLC7A11-AS1 SMAD3 SMAD4 SMURF1 SMURF2 SUFU TACC1 TAFAZZIN TFE3 TIAM1 TP63 TRIB2 TRIM36 TRIM9 TSPAN15 UBC UBE2D2 UBE2R2 UBQLN2 WEE1 WWTR1 XRCC1 ZC3H12A	3 interacting genes: BTRC PPARA RAD23B
Entrez ID		8945	152559
HPRD ID		04596	17819
Ensembl ID		ENSG00000166167	ENSG00000163291
Uniprot IDs		A0A0S2Z4P6 B2R8L3 B7Z3H4 Q9Y297	Q6TCH7
PDB IDs		1P22 2P64 6M90 6M91 6M92 6M93 6M94 6TTU
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Cytosol Protein Catabolic Process Nucleus Positive Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Developmental Process Nucleoplasm Cytoplasm Protein Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Protein Modification Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Catabolic Process Regulation Of Multicellular Organismal Development Response To Oxidative Stress Negative Regulation Of Cell Differentiation Protein Ubiquitination Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Catabolic Process Macromolecule Metabolic Process	Negative Regulation Of Appetite Response To Nutrient Levels Negative Regulation Of Glycolytic Process Regulation Of Circadian Rhythm Cellular Response To Fructose Stimulus Animal Organ Development Negative Regulation Of Cholesterol Storage Regulation Of Response To Food MDM2/MDM4 Family Protein Binding Enamel Mineralization Response To Fructose Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Catabolic Process Regulation Of Transformation Of Host Cell By Virus Cellular Response To Nutrient Levels Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of ATP Biosynthetic Process Tooth Mineralization Rhythmic Process NFAT Protein Binding Positive Regulation Of Transformation Of Host Cell By Virus Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of ATP Biosynthetic Process Behavioral Response To Nicotine Positive Regulation Of Fatty Acid Beta-oxidation Mitogen-activated Protein Kinase Kinase Kinase Binding Positive Regulation Of Fatty Acid Oxidation Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process DNA Damage Sensor Activity Cellular Response To Interleukin-7 Proteasomal Protein Catabolic Process Proteasome Binding XPC Complex Regulation Of Protein Catabolic Process Response To Interleukin-7 Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Circadian Rhythm Ubiquitin Ligase Activator Activity Mammary Gland Epithelial Cell Proliferation Morphogenesis Of An Epithelium Protein Phosphorylated Amino Acid Binding Tissue Morphogenesis Positive Regulation Of T Cell Receptor Signaling Pathway
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