BTRC and PLK4

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		BTRC	PLK4
Description		beta-transducin repeat containing E3 ubiquitin protein ligase	polo like kinase 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	XY Body Nucleus Nucleolus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cleavage Furrow Deuterosome Procentriole Procentriole Replication Complex
	Molecular Function	Protein Binding Beta-catenin Binding Ligase Activity Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Autophagosome Assembly Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Lysosome Organization Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Autophagy Wnt Signaling Pathway Protein Ubiquitination Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels Mammary Gland Epithelial Cell Proliferation Non-canonical NF-kappaB Signal Transduction TORC1 Signaling Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Rhythmic Process T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Cell Cycle Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of TORC1 Signaling	Protein Phosphorylation Centriole Replication Regulation Of Cell Cycle Process Positive Regulation Of Centriole Replication Cilium Assembly Trophoblast Giant Cell Differentiation De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Neddylation Interleukin-1 signaling GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Fostamatinib
Diseases
GWAS		Diastolic blood pressure ( 30224653) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Walking pace ( 33128006)
Interacting Genes		94 interacting genes: AGO2 AKT1 AMER1 ATF4 AXIN1 AXIN2 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CENPW CHPF CHUK CP CRYAA CTNNB1 CUL1 DBN1 DLGAP5 E2F1 FBXW11 FBXW2 FOXO3 FZR1 GHR GLI2 GLI3 GSK3B HERC3 HIPK2 HNRNPU ICE1 IKBKB IL10RA JUP KDR KEAP1 KMT5A LINC00511 LPCAT1 MAPK1 MAPK13 MAPK14 MAPK6 MAPK9 MCL1 MDM2 MITF MYB NFE2 NFE2L2 NFKB1 NFKB2 NFKBIA NFKBIB NHSL2 PAQR3 PCDH8 PDCD4 PHF19 PLK4 PSMA3 PSMD4 RASSF5 RCAN1 RELA RIPK4 RNF7 SKP1 SLC7A11-AS1 SMAD3 SMAD4 SMURF1 SMURF2 SUFU TACC1 TAFAZZIN TFE3 TIAM1 TP63 TRIB2 TRIM36 TRIM9 TSPAN15 UBC UBE2D2 UBE2R2 UBQLN2 WEE1 WWTR1 XRCC1 ZC3H12A	25 interacting genes: ACTR2 AIRIM ARR3 BTRC CHD3 CYLD DCAF1 DNAJB13 DRC4 ELOA MIR126 MTUS2 OSBPL3 PRDM16 SFN SMAD4 SPAG5 TAX1BP3 TEC TENT5B TENT5C TFIP11 TGFBR1 TRIM54 ZBTB39
Entrez ID		8945	10733
HPRD ID		04596	10387
Ensembl ID		ENSG00000166167	ENSG00000142731
Uniprot IDs		A0A0S2Z4P6 B2R8L3 B7Z3H4 Q9Y297	O00444
PDB IDs		1P22 2P64 6M90 6M91 6M92 6M93 6M94 6TTU	2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46 6W38 6W3I 6W3J 8XPG
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Cytosol Protein Catabolic Process Nucleus Positive Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Developmental Process Nucleoplasm Cytoplasm Protein Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Protein Modification Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Catabolic Process Regulation Of Multicellular Organismal Development Response To Oxidative Stress Negative Regulation Of Cell Differentiation Protein Ubiquitination Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Catabolic Process Macromolecule Metabolic Process	Cytoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Centrosome Cytoskeleton Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Microtubule Negative Regulation Of Cell Population Proliferation Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Poly(A) RNA Polymerase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process I-SMAD Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of T Cell Receptor Signaling Pathway Microtubule Binding Regulation Of Extracellular Matrix Assembly Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Extracellular Matrix Organization Microtubule-based Process Regulation Of Cytoskeleton Organization Activin Receptor Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Centriolar Satellite Regulation Of Primary Metabolic Process Ciliary Basal Body Phosphoprotein Binding Negative Regulation Of Interleukin-18-mediated Signaling Pathway Regulation Of Wnt Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Histone H2AT120 Kinase Activity Cell Competition In A Multicellular Organism Neuron Fate Commitment Ventricular Septum Morphogenesis Nucleus Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Wnt Signaling Pathway
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