TDRD3 and FUS

Number of citations of the paper that reports this interaction (PMID 18632687)
17

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		TDRD3	FUS
Gene Name		tudor domain containing 3	FUS RNA binding protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Exon-exon Junction Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Methylated Histone Binding Poly(A) RNA Binding	Nucleotide Binding DNA Binding RNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Chromatin Modification Regulation Of Nucleic Acid-templated Transcription	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Breast size ( 22747683) Menopause (age at onset) ( 22267201)
Protein-Protein Interactions		2 interactors: FUS HIST3H3	39 interactors: ATXN1L CTNNB1 ESRRA EWSR1 GRIN1 GRIN2D IL7R ILF3 KHDRBS3 MAX MDH1 NKD2 NUPR1 PA2G4 POLR2A PRMT1 PSMB7 PTBP1 RBMX RELA RXRA SAFB2 SF1 SFPQ SPI1 SRRM1 SRSF10 SRSF2 SRSF4 SRSF9 SUV39H1 TAF15 TARDBP TDRD3 THRA TNIP1 WBP4 YBX1 ZMYM2
Entrez ID		81550	2521
HPRD ID		11625	00660
Ensembl ID		ENSG00000083544	ENSG00000089280
Uniprot IDs		Q9H7E2	P35637 Q13344 Q6IBQ5
PDB IDs		1WJI 2LTO 3PMT 3PNW 3S6W	2LA6 2LCW 4FDD 4FQ3
Enriched GO Terms of Interacting Partners?			Gene Expression Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process RNA Splicing Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process MRNA Processing Transcription From RNA Polymerase II Promoter Biosynthetic Process MRNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Processing Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Splicing Positive Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Splicing Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription, DNA-templated MRNA Export From Nucleus RNA Export From Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter
Tagcloud ?		ago arginine aromatic asymmetrical binder cage coactivator dimethyl dimethylated gar library mark marks methylated motifs neuron occupy preferentially promiscuous quantitatively recognizes sm smn spf30 splicing symmetrical systematically tudor weakest	antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Difference) ?		ago arginine aromatic asymmetrical binder cage coactivator dimethyl dimethylated gar library mark marks methylated motifs neuron occupy preferentially promiscuous quantitatively recognizes sm smn spf30 splicing symmetrical systematically tudor weakest	antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Intersection) ?