C1QBP and MIR122

Number of citations: 0 (PubMedID 28431233)
Data Source: BioGRID (unspecified method)

		C1QBP	MIR122
Name		complement C1q binding protein	microRNA 122
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Cell Surface Membrane Presynaptic Active Zone Glutamatergic Synapse GABA-ergic Synapse	Extracellular Space RISC Complex Extracellular Exosome Extracellular Vesicle
	Molecular Function	Complement Component C1q Complex Binding Transcription Corepressor Activity MRNA Binding Enzyme Inhibitor Activity Protein Kinase C Binding Protein Binding Hyaluronic Acid Binding Transcription Factor Binding Kininogen Binding Adrenergic Receptor Binding Deoxyribonuclease Inhibitor Activity C5-methylcytidine-containing RNA Reader Activity Mitochondrial Ribosome Binding	None
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Mitochondrial RNA Catabolic Process Adaptive Immune Response Immune System Process MRNA Processing Apoptotic Process Immune Response Complement Activation, Classical Pathway DNA Damage Response RNA Splicing Regulation Of Complement Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Ribosome Biogenesis Cytosolic Ribosome Assembly Positive Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Positive Regulation Of Cell Adhesion Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Defense Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Translation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Trophoblast Cell Migration Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Dendritic Cell Chemotaxis	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways		Apoptotic factor-mediated response Intrinsic Pathway of Fibrin Clot Formation RHOA GTPase cycle RHOC GTPase cycle Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	None
Drugs		Hyaluronic acid Copper	None
GWAS		Rheumatoid arthritis ( 24390342 30423114 )	Gamma glutamyl transferase levels ( 29403010 33339817 ) High density lipoprotein cholesterol levels ( 29083408 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Serum alkaline phosphatase levels ( 33339817 )
Interacting Genes		105 interacting genes: C1QA CDK13 CEBPA COIL DUX4 EXOSC6 FOXP1 GAB1 GABRB1 HABP4 HMGB1 HMGB2 HNRNPD HRK KLF1 MAPK1 MAPK3 MBD1 MBD2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MMP14 NFKBIE NFYB PRKCA PRKCD PRKCZ PRKD1 PRRC2A SHANK3 SRSF1 SRSF9 TOP3B ULK1 YWHAB YWHAG	70 interacting genes: AIMP1 AIMP2 C1QBP CPSF1 DARS1 DDX1 DDX21 DDX3X DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FUS HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LIN28A LIN28B LRPPRC MARS1 MATR3 NOL6 NONO NUDT16L1 NUDT21 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PURA QARS1 RARS1 RBFOX2 RBM14 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SFPQ STRBP SYNCRIP TAF15 TENT2 TRA2A TRA2B UPF1 UTP20 YBX1 YBX3 ZNF346
Entrez ID		708	406906
HPRD ID		03168	Not available
Ensembl ID		ENSG00000108561	ENSG00000284440
Uniprot IDs		Q07021	Not available
PDB IDs		1P32 3RPX 6SZW 7TE3	Not available
GO Terms Enriched among Interactors		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Regulation Of Macromolecule Metabolic Process Regulation Of Angiogenesis Positive Regulation Of MRNA Catabolic Process Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Vasculature Development Regulation Of Cell Migration Regulation Of Cell Motility Negative Regulation Of Developmental Process Regulation Of Locomotion Regulation Of MRNA Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Developmental Process Negative Regulation Of Blood Vessel Endothelial Cell Migration	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of RNA Splicing Nucleus Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex Nucleoplasm Spliceosomal Complex Catalytic Step 2 Spliceosome Post-transcriptional Regulation Of Gene Expression Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Processing Negative Regulation Of MRNA Catabolic Process Regulation Of Gene Expression MRNA Stabilization Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process RNA Stabilization Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding MiRNA Binding Negative Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Positive Regulation Of Gene Expression Negative Regulation Of Translation TRNA Aminoacylation CRD-mediated MRNA Stabilization Nucleolus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Stability Negative Regulation Of Metabolic Process Ligase Activity Regulation Of Metabolic Process