LRRC14 and GPAA1

Data Source: HiPPIP (Novel)

		LRRC14	GPAA1
Name		leucine rich repeat containing 14	glycosylphosphatidylinositol anchor attachment 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Membrane GPI-anchor Transamidase Complex
	Molecular Function	Protein Binding Kinase Binding	GPI-anchor Transamidase Activity Protein Binding GPI Anchor Binding
	Biological Process	Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Toll-like Receptor Signaling Pathway	GPI Anchor Biosynthetic Process Protein Retention In ER Lumen Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis
Pathways		Regulation of NF-kappa B signaling	Attachment of GPI anchor to uPAR
GWAS		Blood metabolite levels ( 26401656 ) Cognitive ability (MTAG) ( 29186694 ) Educational attainment ( 25201988 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Red cell distribution width ( 32888494 )	Asthma ( 31959851 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Serum metabolite concentrations in chronic kidney disease ( 33838163 ) Serum metabolite levels ( 23093944 )
Novel Interactors		2 novel interactors: FOXH1 GPAA1	9 novel interactors: ADAMDEC1 CACNG8 DGAT1 GIT1 LRRC14 LY6E NDRG1 TERF2IP TONSL
Interacting Genes		None recorded	10 interacting genes: AGTR1 AQP2 EIF3E GNRHR GRIK5 PIGK PIGT PIGU PIN1 PRR13
Entrez ID		9684	8733
HPRD ID		14312	04334
Ensembl ID		ENSG00000160959	ENSG00000197858
Uniprot IDs		Q15048	O43292
PDB IDs		Not available	7W72 7WLD 8IMX 8IMY
GO Terms Enriched among Interactors		GPI-anchor Transamidase Activity GPI-anchor Transamidase Complex Maintenance Of Protein Localization In Endoplasmic Reticulum Attachment Of GPI Anchor To Protein GPI Anchor Binding GPI Anchored Protein Biosynthesis Protein Retention In ER Lumen Axial Mesoderm Development Activin Responsive Factor Complex Embryonic Heart Tube Anterior/posterior Pattern Specification Nodal Signaling Pathway Cardiac Right Ventricle Morphogenesis Determination Of Left/right Asymmetry In Lateral Mesoderm Ventricular Trabecula Myocardium Morphogenesis Co-SMAD Binding Hepatocyte Differentiation Heart Field Specification Secondary Heart Field Specification Specification Of Animal Organ Identity Negative Regulation Of Androgen Receptor Signaling Pathway GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Nuclear Androgen Receptor Binding Heart Trabecula Morphogenesis Aorta Morphogenesis Activin Receptor Signaling Pathway BHLH Transcription Factor Binding Cardiac Ventricle Morphogenesis R-SMAD Binding Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Maintenance Of Protein Localization In Organelle Ventricular Cardiac Muscle Tissue Morphogenesis SMAD Binding Maintenance Of Protein Location In Cell Mesoderm Development Cardiac Muscle Tissue Morphogenesis Maintenance Of Protein Location Artery Morphogenesis Outflow Tract Morphogenesis Heart Looping Glycolipid Biosynthetic Process Embryonic Heart Tube Morphogenesis Maintenance Of Location In Cell Muscle Tissue Morphogenesis Maintenance Of Location Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cis-regulatory Region Sequence-specific DNA Binding Glycolipid Metabolic Process Determination Of Bilateral Symmetry	GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Attachment Of GPI Anchor To Protein GPI Anchor Binding GPI-anchor Transamidase Activity GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Glycerolipid Metabolic Process Phosphatidylinositol Metabolic Process Gamma-tubulin Binding Glycerophospholipid Biosynthetic Process Angiotensin Type I Receptor Activity Cis-trans Isomerase Activity Negative Regulation Of ARF Protein Signal Transduction Membrane Lipid Metabolic Process