AOC1 and FOXH1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		AOC1	FOXH1
Name		amine oxidase copper containing 1	forkhead box H1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Peroxisome Plasma Membrane Bicellular Tight Junction Membrane Specific Granule Lumen Extracellular Exosome	Chromatin Nucleus Transcription Regulator Complex Activin Responsive Factor Complex
	Molecular Function	Copper Ion Binding Calcium Ion Binding Protein Binding Primary Methylamine Oxidase Activity Heparin Binding Oxidoreductase Activity Protein Homodimerization Activity Metal Ion Binding Quinone Binding Putrescine Oxidase Activity Diamine Oxidase Activity Histamine Oxidase Activity	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding SMAD Binding Nuclear Androgen Receptor Binding Co-SMAD Binding R-SMAD Binding DNA-binding Transcription Factor Binding
	Biological Process	Amine Metabolic Process Putrescine Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Secondary Heart Field Specification Determination Of Left/right Asymmetry In Lateral Mesoderm Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Determination Of Left/right Symmetry Anterior/posterior Pattern Specification Embryonic Heart Tube Anterior/posterior Pattern Specification Aorta Morphogenesis Nodal Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Negative Regulation Of Androgen Receptor Signaling Pathway Hepatocyte Differentiation Cellular Response To Cytokine Stimulus
Pathways		Phase I - Functionalization of compounds Neutrophil degranulation	Signaling by NODAL Signaling by Activin Germ layer formation at gastrulation Formation of axial mesoderm
Drugs		Amiloride Calcium Diminazene Pimagedine	None
GWAS		Anthropometric traits (multi-trait analysis) ( 30166351 ) Apolipoprotein A1 levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Carpal tunnel syndrome ( 30833571 ) Eyebrow thickness ( 26926045 ) HDL cholesterol ( 30275531 ) HDL cholesterol levels ( 32203549 ) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Multisite chronic pain ( 33830993 ) Serum alkaline phosphatase levels ( 33547301 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 ) Triglyceride levels ( 32203549 ) Triglycerides ( 30275531 ) Type 2 diabetes ( 30297969 ) Urinary metabolite levels in chronic kidney disease ( 31959995 )	Blood metabolite levels ( 26401656 ) Educational attainment ( 25201988 ) General cognitive ability ( 29844566 )
Novel Interactors		None recorded	4 novel interactors: LRRC14 RECQL4 RPL8 SUPT20H
Interacting Genes		14 interacting genes: CYB561A3 DAO DAZAP2 DNM2 FGD1 FOXH1 KLHL20 KRTAP8-1 NTAQ1 POGZ RBPMS2 TIAL1 TLX3 ZC3H10	68 interacting genes: ACTMAP AOC1 ARID5A ATP23 ATXN1L BATF2 C10orf55 CEACAM6 CFAP68 CREBBP CRX CRYBA1 CYSRT1 DAZAP2 DRAP1 FAM168B FAM83A FOXD2 FOXG1 HDHD3 HEY1 HLX HOXA1 HSF4 KLHL26 KRTAP11-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP7-1 LASP1 MAGED1 MGAT5B MSX2 NKX2-5 NOTO OXER1 PLA2G10 PNMA5 PPP1R37 PRR20A PRR20B PRR20C PRR20D PRR20E PRR22 RBM46 RBPMS2 RNF144B SERGEF SMAD2 SMAD3 SMAD4 SOX14 SOX4 TEKT5 TFG TLX3 TSC1 UBAP2 UFSP1 ZC3H10 ZIC1 ZNF34 ZNF503
Entrez ID		26	8928
HPRD ID		00088	04689
Ensembl ID		ENSG00000002726	ENSG00000160973
Uniprot IDs		P19801	O75593
PDB IDs		3HI7 3HIG 3HII 3K5T 3MPH	5XOC 7YZB
GO Terms Enriched among Interactors		Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Cytoplasmic Stress Granule D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process Type II Interferon Binding Protein-N-terminal Glutamine Amidohydrolase Activity D-serine Metabolic Process D-amino Acid Catabolic Process D-amino-acid Oxidase Activity Negative Regulation Of Membrane Tubulation Vesicle Scission Protein K33-linked Ubiquitination Protein-N-terminal Asparagine Amidohydrolase Activity	Transcription Regulator Complex Embryonic Morphogenesis Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intermediate Filament Cardiac Conduction System Development DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding SMAD Protein Complex Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Heteromeric SMAD Protein Complex Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Cardiac Septum Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Regionalization Negative Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Ventricular Septum Morphogenesis I-SMAD Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Pattern Specification Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Activin Responsive Factor Complex Gastrulation Paraxial Mesoderm Morphogenesis Heart Valve Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Differentiation Embryonic Pattern Specification Cardiac Muscle Tissue Development SMAD Protein Signal Transduction Chromatin Binding Mesoderm Morphogenesis R-SMAD Binding Outflow Tract Septum Morphogenesis Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Muscle Cell Differentiation Regulation Of Gene Expression RNA Polymerase II Transcription Regulator Complex Tube Morphogenesis