AOC1

Description		amine oxidase copper containing 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Peroxisome Plasma Membrane Bicellular Tight Junction Membrane Specific Granule Lumen Extracellular Exosome
	Molecular Function	Copper Ion Binding Calcium Ion Binding Protein Binding Primary Methylamine Oxidase Activity Heparin Binding Oxidoreductase Activity Protein Homodimerization Activity Metal Ion Binding Quinone Binding Putrescine Oxidase Activity Diamine Oxidase Activity Histamine Oxidase Activity
	Biological Process	Amine Metabolic Process Putrescine Metabolic Process
Pathways		Phase I - Functionalization of compounds Neutrophil degranulation
Drugs		Amiloride Calcium Diminazene Pimagedine
Diseases
GWAS		Anthropometric traits (multi-trait analysis) ( 30166351) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Carpal tunnel syndrome ( 30833571) Eyebrow thickness ( 26926045) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Multisite chronic pain ( 33830993) Serum alkaline phosphatase levels ( 33547301) Serum metabolite concentrations in chronic kidney disease ( 29545352) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 30297969) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		14 interacting genes: CYB561A3 DAO DAZAP2 DNM2 FGD1 FOXH1 KLHL20 KRTAP8-1 NTAQ1 POGZ RBPMS2 TIAL1 TLX3 ZC3H10
Entrez ID		26
HPRD ID		00088
Ensembl ID		ENSG00000002726
Uniprot IDs		P19801
PDB IDs		3HI7 3HIG 3HII 3K5T 3MPH
Enriched GO Terms of Interacting Partners?		Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Cytoplasmic Stress Granule D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process Type II Interferon Binding Protein-N-terminal Glutamine Amidohydrolase Activity D-serine Metabolic Process D-amino Acid Catabolic Process D-amino-acid Oxidase Activity Negative Regulation Of Membrane Tubulation Vesicle Scission Protein K33-linked Ubiquitination Protein-N-terminal Asparagine Amidohydrolase Activity
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