FOXG1 and KDM5B

Number of citations of the paper that reports this interaction (PMID 12657635)
24

Data Source:
HPRD (in vivo, two hybrid)

		FOXG1	KDM5B
Gene Name		forkhead box G1	lysine (K)-specific demethylase 5B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Histone Demethylase Activity (H3-trimethyl-K4 Specific) Histone Demethylase Activity (H3-dimethyl-K4 Specific)
	Biological Process	Transcription, DNA-templated Brain Development Aging Negative Regulation Of Transcription, DNA-templated	Chromatin Organization Transcription, DNA-templated Histone H3-K4 Demethylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Negative Regulation Of Transcription, DNA-templated Rhythmic Process Oxidation-reduction Process
Pathways			Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs
Diseases
GWAS		Longevity ( 20834067) Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		16 interactors: APOE EEF1G FOXH1 FOXO1 FOXO3 FOXO4 GDF9 HDAC1 HES1 KDM5B SMAD1 SMAD2 SMAD3 SMAD4 TLE1 TLE3	5 interactors: FOXG1 KDM1A MBD3 PAX9 RB1
Entrez ID		2290	10765
HPRD ID		01283	09251
Ensembl ID		ENSG00000176165	ENSG00000117139
Uniprot IDs		P55316	Q9UFD3 Q9UGL1
PDB IDs			2MA5
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Response To Growth Factor Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Cellular Macromolecule Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Macromolecule Biosynthetic Process Response To Transforming Growth Factor Beta Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway RNA Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Proliferation Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter Primary MiRNA Processing Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Differentiation Mesonephros Development Organ Development Mesoderm Development Anatomical Structure Development Cardiovascular System Development	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Myeloid Cell Differentiation Chromatin Modification Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Primitive Erythrocyte Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of RNA Metabolic Process Chromatin Organization Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Head Development Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Myeloid Cell Differentiation Chromatin Remodeling Regulation Of Centromere Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Developmental Process Nitrogen Compound Metabolic Process Regulation Of Chromosome Organization Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin Attachment Of Mitotic Spindle Microtubules To Kinetochore Myeloid Cell Differentiation Organ Development Methylation-dependent Chromatin Silencing
Tagcloud ?		accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1	accordingly balb bivalent demethylation e13 e15 e17 embryos epigenetic ezh2 fate germ h3k27me3 h3k4me3 immunofluorescence jmjd3 lysine marks methylation molar organ p0 p3 qpcr set7 spatiotemporal tooth transferases trimethylation
Tagcloud (Difference) ?		accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1	accordingly balb bivalent demethylation e13 e15 e17 embryos epigenetic ezh2 fate germ h3k27me3 h3k4me3 immunofluorescence jmjd3 lysine marks methylation molar organ p0 p3 qpcr set7 spatiotemporal tooth transferases trimethylation
Tagcloud (Intersection) ?