CCNA2 and ITGB3BP

Number of citations of the paper that reports this interaction (PMID 10673397)
2

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CCNA2	ITGB3BP
Gene Name		cyclin A2	integrin beta 3 binding protein (beta3-endonexin)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Cytoplasm	Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding Protein Kinase Binding	Signal Transducer Activity Protein C-terminus Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Nuclear Division Mitotic G2 DNA Damage Checkpoint Ras Protein Signal Transduction Regulation Of G2/M Transition Of Mitotic Cell Cycle Organ Regeneration Response To Estradiol Response To Glucagon Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fibroblast Proliferation Cell Division	Mitotic Cell Cycle Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Mitotic Nuclear Division Cell Adhesion Signal Transduction CENP-A Containing Nucleosome Assembly Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Cell Division Apoptotic Signaling Pathway
Pathways		Cellular Senescence G2/M Transition Orc1 removal from chromatin Cyclin E associated events during G1/S transition Cyclin A/B1 associated events during G2/M transition G1/S Transition G2 Phase Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases DNA Damage/Telomere Stress Induced Senescence Synthesis of DNA Regulation of DNA replication G0 and Early G1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase S Phase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Orc1 removal from chromatin SCF(Skp2)-mediated degradation of p27/p21 Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G2-G2/M phases	Mitotic Prometaphase Signalling by NGF Chromosome Maintenance Cell death signalling via NRAGE, NRIF and NADE Separation of Sister Chromatids Deposition of new CENPA-containing nucleosomes at the centromere p75 NTR receptor-mediated signalling Mitotic Anaphase M Phase Cell Cycle, Mitotic Nucleosome assembly NRIF signals cell death from the nucleus Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS
Protein-Protein Interactions		50 interactors: ARID4A BRCA1 BRCA2 BTG1 CALM1 CDC20 CDC25C CDC27 CDC6 CDK1 CDK2 CDK3 CDK7 CDKN1A CDKN1B CDT1 CKS1B CKS1BP7 CKS2 DTNBP1 E2F1 E2F3 FEN1 FZR1 HERC5 HIRA HIST1H1A HIST1H1B ITGB3BP KAT2B MYBL2 NFYA PGR POLA1 PRC1 PSMD4 PTMA RAD23A RB1 RBL1 RBL2 RPA1 SKP1 SKP2 SP1 TAF1 TP53 TRAF3IP1 UBTF USP37	21 interactors: ACTN2 APP ARFIP2 CCNA2 COL4A3BP DDX24 ESR1 ITGB3 ITGB5 KDM1A KIFC3 MAPK6 MTA1 NFKB1 PIH1D2 RECQL5 RXRA RXRG SVIL THRA UBR7
Entrez ID		890	23421
HPRD ID		00453	09267
Ensembl ID		ENSG00000145386	ENSG00000142856
Uniprot IDs		P20248	Q13352
PDB IDs		1E9H 1FIN 1FVV 1GY3 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1JST 1JSU 1OGU 1OI9 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P5E 1PKD 1QMZ 1URC 1VYW 2BKZ 2BPM 2C4G 2C5N 2C5O 2C5V 2C5X 2C6T 2CCH 2CCI 2CJM 2I40 2IW6 2IW8 2IW9 2UUE 2UZB 2UZD 2UZE 2UZL 2V22 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 3EID 3EJ1 3EOC 3F5X 4BCK 4BCM 4BCN 4BCP 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4FX3
Enriched GO Terms of Interacting Partners?		Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Organelle Organization Cell Cycle Checkpoint Cell Division Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Chromosome Organization Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Chromatin Organization Regulation Of Protein Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Mitotic Nuclear Division Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Regulation Of Protein Catabolic Process Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Regulation Of Cell Proliferation Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Positive Regulation Of Gene Expression Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Cell Cycle Signal Transduction By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Proteasomal Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Chromatin Modification DNA Replication Positive Regulation Of Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Heterocycle Metabolic Process	Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Response To Lipid Hormone-mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Cellular Metabolic Process Signaling Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Gene Expression Cell Communication Cellular Response To Lipid Regulation Of Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Protein Homotetramerization Platelet Degranulation DNA-templated Transcription, Initiation Response To Steroid Hormone Response To Stimulus Signal Transduction Response To Organic Cyclic Compound Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Organelle Organization Response To Hormone Cellular Response To Hormone Stimulus Protein Tetramerization Cellular Response To Stimulus Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Negative Regulation Of Lipid Transport Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of RNA Metabolic Process Mating Behavior Tissue Development Organ Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Coagulation Cell-matrix Adhesion Hemostasis
Tagcloud ?		calm3 cblb ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		calm3 cblb ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?