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CCNA2 and RBL1
Number of citations of the paper that reports this interaction (PubMedID
33961781
)
97
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vivo, in vitro)
CCNA2
RBL1
Description
cyclin A2
RB transcriptional corepressor like 1
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Female Pronucleus
Male Pronucleus
Nucleus
Nucleoplasm
Cytoplasm
Microtubule Organizing Center
Cytosol
Cyclin A2-CDK1 Complex
Cyclin A2-CDK2 Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Molecular Function
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Protein Domain Specific Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Protein Binding
Promoter-specific Chromatin Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Regulation Of DNA Replication
DNA-templated Transcription
Ras Protein Signal Transduction
Animal Organ Regeneration
Response To Estradiol
Response To Glucagon
Cellular Response To Platelet-derived Growth Factor Stimulus
Post-translational Protein Modification
Cellular Response To Leptin Stimulus
Mitotic Cell Cycle Phase Transition
Cell Cycle G1/S Phase Transition
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Fibroblast Proliferation
Cell Division
Cellular Response To Cocaine
Cellular Response To Luteinizing Hormone Stimulus
Cellular Response To Estradiol Stimulus
Cellular Response To Hypoxia
Cellular Response To Nitric Oxide
Cochlea Development
Cellular Response To Insulin-like Growth Factor Stimulus
Positive Regulation Of DNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Cell Differentiation
Regulation Of Lipid Kinase Activity
Regulation Of Cell Cycle
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Cellular Senescence
Pathways
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
Telomere Extension By Telomerase
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
G1/S-Specific Transcription
Cyclin D associated events in G1
Drugs
4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine
6-O-Cyclohexylmethyl Guanine
[4-(2-Amino-4-Methyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(3-Nitro-Phenyl)-Amine
4-(2,4-Dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluoromethyl)phenyl]-2-pyrimidinamine
4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE
N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamide
2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE
O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE
(2S)-N-[(3E)-5-Cyclopropyl-3H-pyrazol-3-ylidene]-2-[4-(2-oxo-1-imidazolidinyl)phenyl]propanamide
N-cyclopropyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine
6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE
5-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDE
4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]-2-FURYL}-N-METHYLBENZENESULFONAMIDE
4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE
4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDE
4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACID
N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINE
4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE
1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID
4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
4-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUM
4-Methyl-5-[(2Z)-2-{[4-(4-morpholinyl)phenyl]imino}-2,5-dihydro-4-pyrimidinyl]-1,3-thiazol-2-amine
6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINE
4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE
3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE
(2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol
3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL
1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid
(2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol
1-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDE
4-{[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO}BENZAMIDE
Variolin B
Diseases
GWAS
Mean corpuscular hemoglobin (
32888494
)
Height (
25429064
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
28957414
32888494
)
Interacting Genes
46 interacting genes:
ARID4A
BRCA1
BRCA2
BTG1
BUB1B
CALM1
CDC20
CDC25C
CDC6
CDK1
CDK2
CDK3
CDKN1A
CDKN1B
CDT1
DTNBP1
E2F1
E2F3
FANCC
FEN1
H1-1
H1-5
HERC5
HIRA
ITGB3BP
KAT2B
MAD2L1
MAGEA11
MYBL2
NFYA
PGR
PRC1
PSMD4
PTMA
RAD23A
RB1
RBL1
RBL2
SKP1
SKP2
SP1
TAF1
TP53
TRAF3IP1
UBTF
USP37
55 interacting genes:
AOX1
BEGAIN
BRCA1
BRF1
CCNA1
CCNA2
CCND1
CCNE1
CDK2
CDK4
CDK6
CEBPA
CREG1
DGKZ
DHX30
DYRK1A
E2F1
E2F4
E2F5
EPHA2
FN1
GOLGA2
HDAC1
ID2
IRF3
KDM5A
KMT5C
LAMB2
MAPK6
MCM7
MYBL2
MYC
NR2E3
NR4A1
NUCB1
PHB1
PLSCR1
PPP1R9B
PPP2R3A
RBBP8
RBBP9
RINT1
SMAD2
SMAD3
SMAD4
SMARCA4
SNRPD3
SNW1
SP1
SUV39H1
TAF1
TOP1
TP53BP1
TSC22D2
USP4
Entrez ID
890
5933
HPRD ID
00453
00312
Ensembl ID
ENSG00000145386
ENSG00000080839
Uniprot IDs
P20248
P28749
PDB IDs
1E9H
1FIN
1FVV
1GY3
1H1P
1H1Q
1H1R
1H1S
1H24
1H25
1H26
1H27
1H28
1JST
1JSU
1OGU
1OI9
1OIU
1OIY
1OKV
1OKW
1OL1
1OL2
1P5E
1PKD
1QMZ
1URC
1VYW
2BKZ
2BPM
2C4G
2C5N
2C5O
2C5V
2C5X
2C6T
2CCH
2CCI
2CJM
2I40
2IW6
2IW8
2IW9
2UUE
2UZB
2UZD
2UZE
2UZL
2V22
2WEV
2WFY
2WHB
2WIH
2WIP
2WMA
2WMB
2WPA
2WXV
2X1N
3EID
3EJ1
3EOC
3F5X
4BCK
4BCM
4BCN
4BCP
4CFM
4CFN
4CFU
4CFV
4CFW
4CFX
4EOI
4EOJ
4EOK
4EOL
4EOM
4EON
4EOO
4EOP
4EOQ
4EOR
4EOS
4FX3
5CYI
5IF1
5LMK
5NEV
6ATH
6GVA
6P3W
6Q6G
6Q6H
6RIJ
6SG4
7ACK
7B5L
7B5R
7B7S
7LUO
7MKX
7QHL
8B54
8BYA
8BZO
1H28
4YOO
4YOS
4YOZ
5TUV
7SMC
7SMD
7SME
7SMF
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Regulation Of Cell Cycle Process
Regulation Of Cell Cycle
Regulation Of Cell Cycle Phase Transition
Mitotic Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Nucleus
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin Organization
Regulation Of Cell Cycle G1/S Phase Transition
Cell Division
Regulation Of DNA Metabolic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Chromosome Organization
Regulation Of DNA Replication
Positive Regulation Of Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Chromatin Remodeling
Chromosome Organization
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
G2/M Transition Of Mitotic Cell Cycle
Signal Transduction In Response To DNA Damage
Cell Cycle G2/M Phase Transition
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Sister Chromatid Segregation
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Population Proliferation
Cyclin Binding
Positive Regulation Of Cell Cycle Process
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Cell Cycle G1/S Phase Transition
Mitotic DNA Integrity Checkpoint Signaling
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Chromosome Segregation
Mitotic Checkpoint Complex
Regulation Of Lipid Kinase Activity
Nucleoplasm
Transcription Regulator Complex
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Regulation Of Cell Cycle Phase Transition
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of RNA Metabolic Process
DNA Damage Response
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Metabolic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Cycle Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Intracellular Signal Transduction
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Nucleus
Cellular Response To Stress
Mitotic Cell Cycle Phase Transition
Response To Stress
Cell Cycle Phase Transition
Response To Growth Factor
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Mitotic Cell Cycle
Cyclin-dependent Protein Kinase Holoenzyme Complex
DNA Binding
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