CCNA2 and USP37

Number of citations of the paper that reports this interaction (PMID 21596315)
21

Data Source:
BioGRID (enzymatic study)

		CCNA2	USP37
Gene Name		cyclin A2	ubiquitin specific peptidase 37
Image
Gene Ontology Annotations	Cellular Component	Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Cytoplasm	Nucleus
	Molecular Function	Protein Binding Protein Kinase Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Protein Kinase Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Nuclear Division Mitotic G2 DNA Damage Checkpoint Ras Protein Signal Transduction Regulation Of G2/M Transition Of Mitotic Cell Cycle Organ Regeneration Response To Estradiol Response To Glucagon Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fibroblast Proliferation Cell Division	G1/S Transition Of Mitotic Cell Cycle Mitotic Nuclear Division Protein Deubiquitination Protein K11-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Division Regulation Of Proteasomal Protein Catabolic Process Protein K48-linked Deubiquitination
Pathways		Cellular Senescence G2/M Transition Orc1 removal from chromatin Cyclin E associated events during G1/S transition Cyclin A/B1 associated events during G2/M transition G1/S Transition G2 Phase Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases DNA Damage/Telomere Stress Induced Senescence Synthesis of DNA Regulation of DNA replication G0 and Early G1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase S Phase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Orc1 removal from chromatin SCF(Skp2)-mediated degradation of p27/p21 Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G2-G2/M phases
Drugs
Diseases
GWAS
Protein-Protein Interactions		50 interactors: ARID4A BRCA1 BRCA2 BTG1 CALM1 CDC20 CDC25C CDC27 CDC6 CDK1 CDK2 CDK3 CDK7 CDKN1A CDKN1B CDT1 CKS1B CKS1BP7 CKS2 DTNBP1 E2F1 E2F3 FEN1 FZR1 HERC5 HIRA HIST1H1A HIST1H1B ITGB3BP KAT2B MYBL2 NFYA PGR POLA1 PRC1 PSMD4 PTMA RAD23A RB1 RBL1 RBL2 RPA1 SKP1 SKP2 SP1 TAF1 TP53 TRAF3IP1 UBTF USP37	4 interactors: BTRC CCNA2 MYC YWHAG
Entrez ID		890	57695
HPRD ID		00453	07506
Ensembl ID		ENSG00000145386	ENSG00000135913
Uniprot IDs		P20248	Q86T82
PDB IDs		1E9H 1FIN 1FVV 1GY3 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1JST 1JSU 1OGU 1OI9 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P5E 1PKD 1QMZ 1URC 1VYW 2BKZ 2BPM 2C4G 2C5N 2C5O 2C5V 2C5X 2C6T 2CCH 2CCI 2CJM 2I40 2IW6 2IW8 2IW9 2UUE 2UZB 2UZD 2UZE 2UZL 2V22 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 3EID 3EJ1 3EOC 3F5X 4BCK 4BCM 4BCN 4BCP 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4FX3	3U12
Enriched GO Terms of Interacting Partners?		Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Organelle Organization Cell Cycle Checkpoint Cell Division Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Chromosome Organization Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Chromatin Organization Regulation Of Protein Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Mitotic Nuclear Division Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Regulation Of Protein Catabolic Process Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Regulation Of Cell Proliferation Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Positive Regulation Of Gene Expression Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Cell Cycle Signal Transduction By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Proteasomal Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Chromatin Modification DNA Replication Positive Regulation Of Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Heterocycle Metabolic Process	G2/M Transition Of Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Positive Regulation Of Fibroblast Proliferation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Fibroblast Proliferation Regulation Of Catalytic Activity Mitotic Cell Cycle Response To Organic Substance Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Regulation Of Cell Cycle Fibroblast Apoptotic Process Branching Morphogenesis Of An Epithelial Tube Morphogenesis Of A Branching Epithelium Regulation Of Phosphorylation Morphogenesis Of A Branching Structure Positive Regulation Of Transcription, DNA-templated Wnt Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process System Development Positive Regulation Of Gene Expression Negative Regulation Of Monocyte Differentiation Positive Regulation Of Cell Proliferation Involved In Kidney Development Positive Regulation Of Cellular Biosynthetic Process Epithelial Tube Morphogenesis Negative Regulation Of Phosphorylation Multicellular Organismal Development Intracellular Signal Transduction Cellular Response To Organic Substance Anatomical Structure Development Tube Morphogenesis Negative Regulation Of Cell Cycle Response To Peptide Hormone Regulation Of Monocyte Differentiation Response To Peptide Signal Transduction Negative Regulation Of Cellular Metabolic Process Morphogenesis Of An Epithelium Developmental Process Positive Regulation Of Circadian Rhythm Mitotic G2 DNA Damage Checkpoint Regulation Of Telomere Maintenance Signaling Positive Regulation Of DNA Biosynthetic Process
Tagcloud ?		calm3 cblb ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9	alleviated altogether apl arsenic correlating finger fusions interacted mapping modulating moiety peptidase plzf pml predominantly progenitor promyelocytic proteasome rara remission rnai screen stability steady transduced transformation translocations trioxide ubiquitination
Tagcloud (Difference) ?		calm3 cblb ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9	alleviated altogether apl arsenic correlating finger fusions interacted mapping modulating moiety peptidase plzf pml predominantly progenitor promyelocytic proteasome rara remission rnai screen stability steady transduced transformation translocations trioxide ubiquitination
Tagcloud (Intersection) ?