PLEKHG2 and B9D2

		PLEKHG2	B9D2
Description		pleckstrin homology and RhoGEF domain containing G2	B9 domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Membrane MKS Complex Ciliary Basal Body Cell Projection
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding	Protein Binding Gamma-tubulin Binding
	Biological Process	Regulation Of Actin Filament Polymerization	Cell Projection Organization Cilium Assembly
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle RAC1 GTPase cycle	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778 32469254) Preterm birth (maternal effect) ( 28877031) Pulse pressure ( 27841878)
Interacting Genes		8 interacting genes: ACTN3 APP CDC42 GNG2 PIN1 RAC1 RHOA XRN1	8 interacting genes: ALKBH7 P4HA3 PLEKHA7 QARS1 SAXO4 SPAG8 TLX3 VPS25
Entrez ID		64857	80776
HPRD ID		15148	14613
Ensembl ID		ENSG00000090924	ENSG00000123810
Uniprot IDs		E7ESZ3 Q9H7P9	Q9BPU9
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Junction Organization Dendrite Positive Regulation Of Supramolecular Fiber Organization Supramolecular Fiber Organization Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Postsynapse Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Phosphorus Metabolic Process G Protein Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Oxidative Phosphorylation Small GTPase-mediated Signal Transduction Negative Regulation Of Cellular Respiration Cell Projection Regulation Of Synapse Organization Regulation Of Cytokinesis Thioesterase Binding Positive Regulation Of Phosphate Metabolic Process Regulation Of Stress Fiber Assembly Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Supramolecular Fiber Organization Actin Filament-based Process Regulation Of Generation Of Precursor Metabolites And Energy Intracellular Signaling Cassette Cellular Response To Catecholamine Stimulus Establishment Of Epithelial Cell Apical/basal Polarity Focal Adhesion Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Postsynapse Organization Response To Catecholamine Regulation Of Oxidative Phosphorylation Positive Regulation Of Leukocyte Migration GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell Motility Regulation Of Cell Division Positive Regulation Of Lamellipodium Assembly Cell-cell Junction Organization Regulation Of Aerobic Respiration Regulation Of Locomotion Positive Regulation Of Cytoskeleton Organization
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