PLEKHG2

Gene Name		pleckstrin homology domain containing, family G (with RhoGef domain) member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Protein-protein Interactions		8 interactors: ACTN3 APP CDC42 GNB1 GNG2 RAC1 RHOA XRN1
Entrez ID		64857
HPRD ID		15148
Ensembl ID		ENSG00000090924
Uniprot IDs		E7ESZ3 Q9H7P9
PDB IDs
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Platelet Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cell-cell Junction Organization Cell Activation Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Guidance Cellular Response To Prostaglandin E Stimulus Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Axonogenesis Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Positive Regulation Of Cell Morphogenesis Involved In Differentiation Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Small GTPase Mediated Signal Transduction Cellular Response To Catecholamine Stimulus Neuron Projection Morphogenesis Actin Filament-based Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Cycle Process Movement Of Cell Or Subcellular Component Regulation Of Substrate Adhesion-dependent Cell Spreading Cell Morphogenesis Involved In Differentiation Dopamine Receptor Signaling Pathway Substantia Nigra Development Brain Development Cellular Response To Glucagon Stimulus Positive Regulation Of Cytokinesis Head Development Positive Regulation Of Cell Projection Organization Neuron Projection Development Positive Regulation Of Cell Cycle Positive Regulation Of Stress Fiber Assembly Cellular Response To Fatty Acid Cell Projection Morphogenesis Regulation Of Cell Development Cell Part Morphogenesis Positive Regulation Of Actin Filament Bundle Assembly Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Response To External Stimulus Regulation Of Phosphatidylinositol 3-kinase Activity Response To Glucagon
Tagcloud ?		abl1 candidates cdc42 constitutively csrc cytoskeletal ephrinb2 flj00018 gbetagamma gtp guanine hek293 heterotrimeric homology kinse mutagenesis partner phosphorylated pik3r3 rac reorganization rho rhogef sh2 substitution throughput turn tyr489 tyrosine