PLEKHG2 and ACTN3

Number of citations: 71 (PubMedID 29892012)
Data Source: BioGRID (two hybrid)

		PLEKHG2	ACTN3
Name		pleckstrin homology and RhoGEF domain containing G2	actinin alpha 3
Structure		No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytoplasm Cytosol Actin Filament Plasma Membrane Brush Border Focal Adhesion Actin Cytoskeleton Sarcomere Z Disc Cell Junction Cortical Actin Cytoskeleton Pseudopodium Cell Projection Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Regulation Of Actin Filament Polymerization	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Actin Cytoskeleton Organization Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Muscle Cell Development Bone Morphogenesis Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Muscle System Process Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Relaxation Of Muscle Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle RAC1 GTPase cycle	Nephrin family interactions Striated Muscle Contraction
GWAS		No GWAS studies recorded	Bipolar disorder ( 21926972 ) Frontotemporal dementia with GRN mutation ( 29724592 )
Novel Interactors		1 novel interactors: B9D2	3 novel interactors: BBS1 DYNC1I2 XPO1
Interacting Genes		8 interacting genes: ACTN3 APP CDC42 GNG2 PIN1 RAC1 RHOA XRN1	61 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A ASB9 ATP23 BRCA1 C1orf94 CADPS CATSPERT CIMAP1B CIMIP1 CTAG1A CTAG1B CTDSP1 CXCL5 DDAH2 DUX1 DUX4L9 ECM1 FAM90A1 GLIS2 HGS HOXD12 HSF2BP IVD KCTD6 KRT6C LHX3 LINC01554 LNX1 MAGEA6 MICALL2 MYOT MYOZ1 MYPN NDUFAB1 NEBL NKAPD1 NRAP PCCB PKP2 PLEKHG2 POU6F2 PPP1R18 PTK6 REL RNF111 RTP5 SNAI1 SOHLH1 SUMO1P1 SYNPO2L TRAF1 TRAF2 TRIM29 TTN USP2 ZNF343 ZNF426
Entrez ID		64857	89
HPRD ID		15148	02148
Ensembl ID		ENSG00000090924	ENSG00000248746
Uniprot IDs		E7ESZ3 Q9H7P9	A0A087WSZ2 B4DZQ2 Q08043
PDB IDs		Not available	1TJT 1WKU 3LUE
GO Terms Enriched among Interactors		Cell Junction Organization Dendrite Positive Regulation Of Supramolecular Fiber Organization Supramolecular Fiber Organization Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Postsynapse Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Phosphorus Metabolic Process G Protein Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Oxidative Phosphorylation Small GTPase-mediated Signal Transduction Negative Regulation Of Cellular Respiration Cell Projection Regulation Of Synapse Organization Regulation Of Cytokinesis Thioesterase Binding Positive Regulation Of Phosphate Metabolic Process Regulation Of Stress Fiber Assembly Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Supramolecular Fiber Organization Actin Filament-based Process Regulation Of Generation Of Precursor Metabolites And Energy Intracellular Signaling Cassette Cellular Response To Catecholamine Stimulus Establishment Of Epithelial Cell Apical/basal Polarity Focal Adhesion Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Postsynapse Organization Response To Catecholamine Regulation Of Oxidative Phosphorylation Positive Regulation Of Leukocyte Migration GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell Motility Regulation Of Cell Division Positive Regulation Of Lamellipodium Assembly Cell-cell Junction Organization Regulation Of Aerobic Respiration Regulation Of Locomotion Positive Regulation Of Cytoskeleton Organization	Z Disc Pseudopodium Sarcomere Organization Actin Filament Binding Actin Binding Identical Protein Binding Cytoskeletal Protein Binding Actin Cytoskeleton Organization Actin Filament-based Process Structural Constituent Of Muscle Actinin Binding Muscle Alpha-actinin Binding Protein Binding Cardiac Muscle Thin Filament Assembly Actomyosin Structure Organization Actin Cytoskeleton I Band FATZ Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoskeleton Organization Telethonin Binding Stress Fiber Fascia Adherens Supramolecular Fiber Organization Muscle Cell Development Postsynaptic Actin Cytoskeleton Thioesterase Binding