ASB9 and EXOSC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ASB9	EXOSC1
Description		ankyrin repeat and SOCS box containing 9	exosome component 1
Image
GO Annotations	Cellular Component	Mitochondrion Cytosol Cul5-RING Ubiquitin Ligase Complex	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleic Acid Binding RNA Binding RNA Exonuclease Activity Protein Binding
	Biological Process	Protein Ubiquitination Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process	RRNA Processing RNA Processing RNA Catabolic Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Blood protein levels ( 30072576) Early spontaneous preterm birth ( 31194736) Spontaneous preterm birth with premature rupture of membranes ( 31194736)
Interacting Genes		11 interacting genes: ACTN3 ASB13 CKB CKMT1A CKMT1B EXOSC1 HIF1AN LCK PLCG2 RELA UBE2D1	36 interacting genes: A2M APP ASB9 CDC37 CPSF7 DDIT4L DMRTB1 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 FHL3 KCTD1 LNX1 LSM3 MAST1 NOS3 NUP160 PAK5 PRRC2B PTEN RBPMS REL RNF32 SF1 SH3GLB2 TCF4 TEX11 UPF2 WDR83 XRN1 ZNF143 ZNF76
Entrez ID		140462	51013
HPRD ID		06452	16223
Ensembl ID		ENSG00000102048	ENSG00000171311
Uniprot IDs		A0A024RBW7 Q96DX5	B1AMU3 Q9Y3B2
PDB IDs		3D9H 3ZKJ 3ZNG 6V9H	2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Phosphocreatine Biosynthetic Process Creatine Kinase Activity Transferase Activity, Transferring Phosphorus-containing Groups Ankyrin Repeat Binding Positive Regulation Of T Cell Receptor Signaling Pathway Modified Amino Acid Metabolic Process Positive Regulation Of Antigen Receptor-mediated Signaling Pathway NF-kappaB Binding Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Organophosphate Biosynthetic Process Positive Regulation Of Interleukin-12 Production Kinase Activity Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Release Of Sequestered Calcium Ion Into Cytosol Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Negative Regulation Of Sequestering Of Calcium Ion [protein]-asparagine 3-dioxygenase Activity Regulation Of Interleukin-12 Production Cytosol Platelet Activation Catalytic Activity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Futile Creatine Cycle ATP Binding Immune Response-activating Signaling Pathway NF-kappaB P50/p65 Complex Peptidyl-aspartic Acid 3-dioxygenase Activity Calcium Ion Transmembrane Import Into Cytosol Regulation Of Calcium-mediated Signaling Positive Regulation Of Cell Differentiation Positive Regulation Of Interleukin-6 Production Positive Regulation Of Bone Mineralization Involved In Bone Maturation Inositol Trisphosphate Biosynthetic Process Positive Regulation Of Schwann Cell Differentiation Response To Cobalamin Peptidyl-histidine Dioxygenase Activity Organophosphate Metabolic Process Immune Response-regulating Signaling Pathway Activation Of Immune Response T Cell Receptor Signaling Pathway	Nuclear MRNA Surveillance Exoribonuclease Complex RRNA Catabolic Process U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Nuclear RNA Surveillance Nuclear Exosome (RNase Complex) Exosome (RNase Complex) RNA Surveillance SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing SnRNA Processing MRNA Catabolic Process RNA 3'-end Processing MRNA Metabolic Process SnRNA Metabolic Process RNA Catabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process MRNA 3'-UTR AU-rich Region Binding 3'-5'-RNA Exonuclease Activity RRNA 3'-end Processing TRNA Decay Nucleobase-containing Compound Catabolic Process RNA Processing RRNA Metabolic Process RNA Binding RRNA Processing Nucleus RNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Protein Binding Macromolecule Catabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation DNA Deamination Negative Regulation Of Gene Expression Histone MRNA Catabolic Process Synapse Maturation Nucleic Acid Metabolic Process Sno(s)RNA Metabolic Process Cytosol Regulation Of Gene Expression P-body Histone MRNA Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?