ASB9 and CKMT1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ASB9	CKMT1B
Description		ankyrin repeat and SOCS box containing 9	creatine kinase, mitochondrial 1B
Image
GO Annotations	Cellular Component	Mitochondrion Cytosol Cul5-RING Ubiquitin Ligase Complex	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Catalytic Activity Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups
	Biological Process	Protein Ubiquitination Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process	Phosphocreatine Biosynthetic Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Creatine metabolism
Drugs			Creatine Phosphocreatine
Diseases
GWAS		Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: ACTN3 ASB13 CKB CKMT1A CKMT1B EXOSC1 HIF1AN LCK PLCG2 RELA UBE2D1	12 interacting genes: ASB9 CALM1 CTNNA3 HPCA NUTF2 OCM PPP1R16A PSMC3 RXRG SFRP4 SLC25A5 VDAC1
Entrez ID		140462	1159
HPRD ID		06452	00424
Ensembl ID		ENSG00000102048	ENSG00000237289
Uniprot IDs		A0A024RBW7 Q96DX5	P12532
PDB IDs		3D9H 3ZKJ 3ZNG 6V9H	1QK1 9B04 9B05 9B0T 9B0U 9B14 9B16
Enriched GO Terms of Interacting Partners?		Phosphocreatine Biosynthetic Process Creatine Kinase Activity Transferase Activity, Transferring Phosphorus-containing Groups Ankyrin Repeat Binding Positive Regulation Of T Cell Receptor Signaling Pathway Modified Amino Acid Metabolic Process Positive Regulation Of Antigen Receptor-mediated Signaling Pathway NF-kappaB Binding Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Organophosphate Biosynthetic Process Positive Regulation Of Interleukin-12 Production Kinase Activity Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Release Of Sequestered Calcium Ion Into Cytosol Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Negative Regulation Of Sequestering Of Calcium Ion [protein]-asparagine 3-dioxygenase Activity Regulation Of Interleukin-12 Production Cytosol Platelet Activation Catalytic Activity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Futile Creatine Cycle ATP Binding Immune Response-activating Signaling Pathway NF-kappaB P50/p65 Complex Peptidyl-aspartic Acid 3-dioxygenase Activity Calcium Ion Transmembrane Import Into Cytosol Regulation Of Calcium-mediated Signaling Positive Regulation Of Cell Differentiation Positive Regulation Of Interleukin-6 Production Positive Regulation Of Bone Mineralization Involved In Bone Maturation Inositol Trisphosphate Biosynthetic Process Positive Regulation Of Schwann Cell Differentiation Response To Cobalamin Peptidyl-histidine Dioxygenase Activity Organophosphate Metabolic Process Immune Response-regulating Signaling Pathway Activation Of Immune Response T Cell Receptor Signaling Pathway	Mitochondrial Permeability Transition Pore Complex Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Catabolic Process Mitochondrial Nucleoid Regulation Of Mitophagy Negative Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Action Potential Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Sodium-dependent Phosphate Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Transmembrane Transporter Activity Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Contraction Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Receptor Internalization Response To Ketamine Adenine Nucleotide Transmembrane Transporter Activity Mitochondrial ADP Transmembrane Transport ATP:ADP Antiporter Activity MMXD Complex Positive Regulation Of Macroautophagy Regulation Of Transport Adenine Transmembrane Transporter Activity Oxidative Phosphorylation Uncoupler Activity Adenine Transport Transmembrane Transporter Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Transport Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Response To Calcium Ion Negative Regulation Of Monoatomic Ion Transport Regulation Of Heart Rate Negative Regulation Of Transmembrane Transport Regulation Of Monoatomic Ion Transport Regulation Of Striated Muscle Contraction Response To Aroclor 1254 Regulation Of Receptor-mediated Endocytosis Dendritic Spine Head
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