MTMR3 and LONRF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MTMR3	LONRF1
Description		myotubularin related protein 3	LON peptidase N-terminal domain and ring finger 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Cytoplasm Cytosol
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Zinc Ion Binding Hydrolase Activity Protein Phosphatase Binding Metal Ion Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Molecular Adaptor Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Macroautophagy Cellular Response To Glucose Starvation Phosphatidylinositol Dephosphorylation Regulation Of Phosphatidylinositol Dephosphorylation Midbody Abscission Phosphatidylinositol 5-phosphate Metabolic Process Regulation Of Autophagosome Assembly
Pathways		Macroautophagy Synthesis of PIPs at the plasma membrane	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Behcet's disease ( 33393726) Cerebrospinal P-tau181p levels ( 28247064) Crohn's disease ( 21102463 28067908) Delirium ( 29631748) Dentures ( 31235808) Estimated glomerular filtration rate ( 31451708 31152163) Fasting glucose ( 34059833) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) IgA nephropathy ( 22197929) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Lung cancer ( 21725308) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Nephropathy ( 21399633) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Refractive error ( 32231278) Tonsillectomy ( 28928442 27182965 27941131) Type 2 diabetes ( 30297969 29632382)	Apolipoprotein A1 levels ( 32203549) Colorectal cancer (diet interaction) ( 24743840) HDL cholesterol levels ( 32203549)
Interacting Genes		5 interacting genes: DSCR9 EXOSC5 FGFR2 HIVEP1 LONRF1	98 interacting genes: ADAMTSL4 ALAS1 AP2B1 ATG9A AVPI1 BRCA1 BYSL C4orf17 CALCOCO2 CBLL2 CDKN2D CFP CRX CYSRT1 DSCR9 DVL3 EFHC2 FLACC1 GABPB2 GORASP1 GORASP2 GPRASP3 HLX HOXA1 HSPB1 IHO1 IKZF2 IKZF3 IQCF2 KAT5 KATNBL1 KCTD21 KCTD9 KHDC1 KRT31 KRT35 KRT75 KRTAP1-3 KRTAP13-1 KRTAP13-3 KRTAP19-6 KRTAP19-7 KRTAP3-3 KRTAP6-1 LGALS9B LHX2 LHX4 LNX1 MAGED1 MGAT5B MID2 MRPL38 MTMR3 MYOZ3 NR4A1 NTAQ1 OOEP PATZ1 PAX5 PAX6 PAX8 PICK1 PLSCR1 POU6F2 PPP1R3C PRDM16 PRDM6 PRR35 PSMA1 RBPMS RIMBP3C RPRD1A RSPH1 SFN SLU7 SPRY2 STAU1 STX11 TASOR2 TBX19 TRAF2 TRIM27 TRIM42 TRIM8 TRIM9 UBE2I UBE2L6 UCHL3 USP2 VGLL1 WDR83 XIAP YPEL3 ZFP90 ZNF426 ZNF653 ZNF774 ZNHIT2
Entrez ID		8897	91694
HPRD ID		09151	08674
Ensembl ID		ENSG00000100330	ENSG00000154359
Uniprot IDs		Q13615	Q17RB8
PDB IDs
Enriched GO Terms of Interacting Partners?		Mesenchymal Cell Differentiation Involved In Lung Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Mammary Gland Bud Formation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Branch Elongation Involved In Salivary Gland Morphogenesis Lung-associated Mesenchyme Development Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Pyramidal Neuron Development Positive Regulation Of Lipase Activity Epithelial Cell Differentiation Involved In Prostate Gland Development Bud Elongation Involved In Lung Branching Ventricular Zone Neuroblast Division Prostate Epithelial Cord Elongation Prostate Gland Morphogenesis Mesenchymal Cell Proliferation Involved In Lung Development Endochondral Bone Growth Fibroblast Growth Factor Receptor Activity Otic Vesicle Formation Orbitofrontal Cortex Development Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Lateral Sprouting From An Epithelium Branching Morphogenesis Of A Nerve Lung Lobe Morphogenesis Limb Bud Formation Epidermis Morphogenesis Positive Regulation Of Phospholipase Activity Forebrain Neuroblast Division Lacrimal Gland Development Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Exoribonuclease Complex Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Branching Involved In Labyrinthine Layer Morphogenesis Membranous Septum Morphogenesis Prostate Gland Growth Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance Branching Involved In Salivary Gland Morphogenesis Branching Involved In Prostate Gland Morphogenesis DNA Deamination Branch Elongation Of An Epithelium Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Mesodermal Cell Differentiation	Intermediate Filament Protein Binding Zinc Ion Binding Protein Modification By Small Protein Conjugation Protein Ubiquitination Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Identical Protein Binding Keratin Filament Post-translational Protein Modification Positive Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Activity Regulation Of DNA-templated Transcription Transcription Coactivator Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process Protein Kinase C Inhibitor Activity Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Positive Regulation Of Biosynthetic Process Regulation Of Viral Transcription Regulation Of RNA Metabolic Process Protein Modification Process Establishment Of Spindle Localization Structural Constituent Of Skin Epidermis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Spindle Localization Non-canonical Inflammasome Complex Assembly Telencephalon Regionalization Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cellular Response To Vascular Endothelial Growth Factor Stimulus Outer Dense Fiber Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Cytosol Protein K63-linked Ubiquitination Negative Regulation Of Viral Process Positive Regulation Of Macromolecule Metabolic Process Nucleus
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