MTMR3 and EXOSC5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MTMR3	EXOSC5
Description		myotubularin related protein 3	exosome component 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Zinc Ion Binding Hydrolase Activity Protein Phosphatase Binding Metal Ion Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Molecular Adaptor Activity	3'-5'-RNA Exonuclease Activity DNA Binding RNA Binding RNA Exonuclease Activity Protein Binding
	Biological Process	Protein Dephosphorylation Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Macroautophagy Cellular Response To Glucose Starvation Phosphatidylinositol Dephosphorylation Regulation Of Phosphatidylinositol Dephosphorylation Midbody Abscission Phosphatidylinositol 5-phosphate Metabolic Process Regulation Of Autophagosome Assembly	RRNA Processing RNA Processing RNA Catabolic Process MRNA Catabolic Process RRNA Catabolic Process U4 SnRNA 3'-end Processing DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing
Pathways		Macroautophagy Synthesis of PIPs at the plasma membrane	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Behcet's disease ( 33393726) Cerebrospinal P-tau181p levels ( 28247064) Crohn's disease ( 21102463 28067908) Delirium ( 29631748) Dentures ( 31235808) Estimated glomerular filtration rate ( 31451708 31152163) Fasting glucose ( 34059833) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) IgA nephropathy ( 22197929) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Lung cancer ( 21725308) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Nephropathy ( 21399633) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Refractive error ( 32231278) Tonsillectomy ( 28928442 27182965 27941131) Type 2 diabetes ( 30297969 29632382)	Appendicular lean mass ( 33097823)
Interacting Genes		5 interacting genes: DSCR9 EXOSC5 FGFR2 HIVEP1 LONRF1	82 interacting genes: ACOT11 ADAMTSL4 BIRC2 BORCS6 CALCOCO2 CCDC88B CDK5RAP1 CEP55 CPSF7 DAAM2 DDIT4L DHRS2 DIS3 DMRTB1 DOCK8 EFHC2 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FH FHL3 GOLGA2 HOXC4 IKZF3 KCTD13 KIAA1217 KRT13 KRT27 KRT31 KRT34 KRT35 LCA5L LIPG LRMDA LSM3 LSM5 LZTS2 MEOX2 MPHOSPH6 MTMR3 MTREX MYLIP NKAPD1 NMI NUP210 PA2G4 PALS2 PEG10 PICK1 PIH1D2 PKM POLR2L PRDM6 PTEN REL SFPQ SH3GLB1 SH3GLB2 SHISA6 SNW1 SPTA1 TEX11 TFIP11 TLE5 TNFAIP1 TRIB3 TRIM54 TRIM62 YTHDF3 ZFP90 ZMAT1 ZNF420 ZNF558 ZNF620 ZNF655 ZNF792
Entrez ID		8897	56915
HPRD ID		09151	16222
Ensembl ID		ENSG00000100330	ENSG00000077348
Uniprot IDs		Q13615	Q9NQT4
PDB IDs			2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Mesenchymal Cell Differentiation Involved In Lung Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Mammary Gland Bud Formation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Branch Elongation Involved In Salivary Gland Morphogenesis Lung-associated Mesenchyme Development Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Pyramidal Neuron Development Positive Regulation Of Lipase Activity Epithelial Cell Differentiation Involved In Prostate Gland Development Bud Elongation Involved In Lung Branching Ventricular Zone Neuroblast Division Prostate Epithelial Cord Elongation Prostate Gland Morphogenesis Mesenchymal Cell Proliferation Involved In Lung Development Endochondral Bone Growth Fibroblast Growth Factor Receptor Activity Otic Vesicle Formation Orbitofrontal Cortex Development Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Lateral Sprouting From An Epithelium Branching Morphogenesis Of A Nerve Lung Lobe Morphogenesis Limb Bud Formation Epidermis Morphogenesis Positive Regulation Of Phospholipase Activity Forebrain Neuroblast Division Lacrimal Gland Development Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Exoribonuclease Complex Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Branching Involved In Labyrinthine Layer Morphogenesis Membranous Septum Morphogenesis Prostate Gland Growth Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance Branching Involved In Salivary Gland Morphogenesis Branching Involved In Prostate Gland Morphogenesis DNA Deamination Branch Elongation Of An Epithelium Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Mesodermal Cell Differentiation	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay Nuclear MRNA Surveillance Nuclear RNA Surveillance RNA Surveillance RRNA Processing SnRNA Metabolic Process RRNA Metabolic Process RNA 3'-end Processing RNA Processing SnRNA 3'-end Processing CUT Catabolic Process RNA Catabolic Process 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Processing MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleobase-containing Compound Catabolic Process RNA Metabolic Process Sno(s)RNA Metabolic Process Exoribonuclease Complex TRNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Structural Constituent Of Skin Epidermis Cytosol Intermediate Filament Organization Nucleic Acid Metabolic Process RNA Binding Macromolecule Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Nucleolus Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination
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