MTMR3

Description		myotubularin related protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Zinc Ion Binding Hydrolase Activity Protein Phosphatase Binding Metal Ion Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Molecular Adaptor Activity
	Biological Process	Protein Dephosphorylation Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Macroautophagy Cellular Response To Glucose Starvation Phosphatidylinositol Dephosphorylation Regulation Of Phosphatidylinositol Dephosphorylation Midbody Abscission Phosphatidylinositol 5-phosphate Metabolic Process Regulation Of Autophagosome Assembly
Pathways		Macroautophagy Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Behcet's disease ( 33393726) Cerebrospinal P-tau181p levels ( 28247064) Crohn's disease ( 21102463 28067908) Delirium ( 29631748) Dentures ( 31235808) Estimated glomerular filtration rate ( 31451708 31152163) Fasting glucose ( 34059833) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) IgA nephropathy ( 22197929) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Lung cancer ( 21725308) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Nephropathy ( 21399633) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Refractive error ( 32231278) Tonsillectomy ( 28928442 27182965 27941131) Type 2 diabetes ( 30297969 29632382)
Interacting Genes		5 interacting genes: DSCR9 EXOSC5 FGFR2 HIVEP1 LONRF1
Entrez ID		8897
HPRD ID		09151
Ensembl ID		ENSG00000100330
Uniprot IDs		Q13615
PDB IDs
Enriched GO Terms of Interacting Partners?		Mesenchymal Cell Differentiation Involved In Lung Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Mammary Gland Bud Formation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Branch Elongation Involved In Salivary Gland Morphogenesis Lung-associated Mesenchyme Development Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Pyramidal Neuron Development Positive Regulation Of Lipase Activity Epithelial Cell Differentiation Involved In Prostate Gland Development Bud Elongation Involved In Lung Branching Ventricular Zone Neuroblast Division Prostate Epithelial Cord Elongation Prostate Gland Morphogenesis Mesenchymal Cell Proliferation Involved In Lung Development Endochondral Bone Growth Fibroblast Growth Factor Receptor Activity Otic Vesicle Formation Orbitofrontal Cortex Development Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Lateral Sprouting From An Epithelium Branching Morphogenesis Of A Nerve Lung Lobe Morphogenesis Limb Bud Formation Epidermis Morphogenesis Positive Regulation Of Phospholipase Activity Forebrain Neuroblast Division Lacrimal Gland Development Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Exoribonuclease Complex Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Branching Involved In Labyrinthine Layer Morphogenesis Membranous Septum Morphogenesis Prostate Gland Growth Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance Branching Involved In Salivary Gland Morphogenesis Branching Involved In Prostate Gland Morphogenesis DNA Deamination Branch Elongation Of An Epithelium Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Mesodermal Cell Differentiation
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