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SPHK1 and LYN
Number of citations of the paper that reports this interaction (PubMedID
16316995
)
0
Data Source:
HPRD
(in vivo)
SPHK1
LYN
Description
sphingosine kinase 1
LYN proto-oncogene, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Cilium
Endosome Membrane
Membrane
Endocytic Vesicle
Cytoplasmic Vesicle
Early Endosome Membrane
Intracellular Membrane-bounded Organelle
Synapse
Presynapse
Nucleus
Cytoplasm
Lysosome
Lysosomal Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Adherens Junction
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Crista
Endocytic Vesicle Membrane
Mitochondrial Membrane
Protein-containing Complex
Integrin Alpha2-beta1 Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Postsynaptic Specialization, Intracellular Component
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Lipid Kinase Activity
DNA Binding
Protein Binding
Calmodulin Binding
ATP Binding
Lipid Binding
Sphingosine Kinase Activity
Kinase Activity
Acetyltransferase Activity
Transferase Activity
Sphingosine-1-phosphate Receptor Activity
Protein Phosphatase 2A Binding
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
SH3 Domain Binding
Enzyme Binding
Signaling Receptor Activator Activity
Ubiquitin Protein Ligase Binding
Gamma-tubulin Binding
Glycosphingolipid Binding
Transmembrane Transporter Binding
Protein-containing Complex Binding
Ephrin Receptor Binding
Phosphoprotein Binding
Scaffold Protein Binding
Phosphorylation-dependent Protein Binding
Phosphatidylinositol 3-kinase Activator Activity
Biological Process
Blood Vessel Development
Sphingosine-1-phosphate Receptor Signaling Pathway
Protein Acetylation
Lipid Metabolic Process
Sphingosine Metabolic Process
Inflammatory Response
Brain Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Regulation Of Gene Expression
Positive Regulation Of Peptidyl-threonine Phosphorylation
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Calcium-mediated Signaling
Regulation Of Endocytosis
Sphingolipid Biosynthetic Process
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Ubiquitination
Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-17 Production
Regulation Of Amide Metabolic Process
Response To Tumor Necrosis Factor
Intracellular Signal Transduction
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Negative Regulation Of Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Smooth Muscle Contraction
Sphingosine Biosynthetic Process
Sphingoid Catabolic Process
Regulation Of Lipid Biosynthetic Process
Positive Regulation Of Fibroblast Proliferation
Regulation Of Phagocytosis
Regulation Of Transport
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Multicellular Organismal Process
Cellular Response To Hydrogen Peroxide
Cellular Response To Growth Factor Stimulus
DNA Biosynthetic Process
Sphingolipid Mediated Signaling Pathway
Regulation Of Neuroinflammatory Response
Negative Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Regulation Of Microglial Cell Activation
Regulation Of Endosomal Vesicle Fusion
DNA Damage Checkpoint Signaling
Cell Morphogenesis
B Cell Homeostasis
Regulation Of Cytokine Production
Regulation Of Protein Phosphorylation
Negative Regulation Of Protein Phosphorylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Hematopoietic Progenitor Cell Differentiation
Adaptive Immune Response
Immune System Process
Fc Receptor Mediated Stimulatory Signaling Pathway
Tolerance Induction To Self Antigen
Histamine Secretion By Mast Cell
Platelet Degranulation
Innate Immune Response-activating Signaling Pathway
Negative Regulation Of Myeloid Leukocyte Differentiation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Inhibitory Signaling Pathway
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of B Cell Apoptotic Process
Protein Phosphorylation
Autophagy
Response To Stress
Inflammatory Response
DNA Damage Response
Response To Sterol Depletion
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Toxic Substance
Response To Hormone
Response To Carbohydrate
Positive Regulation Of Neuron Projection Development
Oligodendrocyte Development
Fatty Acid Transport
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Erythrocyte Differentiation
Eosinophil Differentiation
Positive Regulation Of Cell Migration
Negative Regulation Of B Cell Proliferation
Neuron Projection Development
T Cell Costimulation
Lipopolysaccharide-mediated Signaling Pathway
Response To Insulin
Regulation Of Mast Cell Activation
Regulation Of Cell Adhesion Mediated By Integrin
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Interleukin-5-mediated Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
C-X-C Chemokine Receptor CXCR4 Signaling Pathway
B Cell Proliferation
Positive Regulation Of Phosphorylation
Response To Amino Acid
Regulation Of Mast Cell Degranulation
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Response To Peptide Hormone
Innate Immune Response
Regulation Of Erythrocyte Differentiation
Protein Autophosphorylation
Ephrin Receptor Signaling Pathway
Response To Axon Injury
Regulation Of Inflammatory Response
Negative Regulation Of Immune Response
B Cell Receptor Signaling Pathway
Regulation Of B Cell Receptor Signaling Pathway
Negative Regulation Of B Cell Receptor Signaling Pathway
Leukocyte Migration
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Glial Cell Proliferation
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Oligodendrocyte Progenitor Proliferation
Negative Regulation Of Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Cellular Response To Retinoic Acid
Cellular Response To Lipid
Regulation Of Monocyte Chemotaxis
Regulation Of Platelet Aggregation
Dendritic Cell Differentiation
Neuroinflammatory Response
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Dendritic Cell Apoptotic Process
Pathways
Sphingolipid de novo biosynthesis
Association of TriC/CCT with target proteins during biosynthesis
VEGFR2 mediated cell proliferation
Extra-nuclear estrogen signaling
PKR-mediated signaling
GPVI-mediated activation cascade
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
Co-stimulation by CD28
Co-inhibition by CTLA4
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Dectin-2 family
CD209 (DC-SIGN) signaling
CD22 mediated BCR regulation
Cyclin D associated events in G1
Platelet Adhesion to exposed collagen
Signaling by Erythropoietin
Signaling by Erythropoietin
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Signaling by CSF1 (M-CSF) in myeloid cells
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Dasatinib
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Bosutinib
Ponatinib
Nintedanib
Fostamatinib
Diseases
GWAS
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Immature fraction of reticulocytes (
32888494
27863252
)
Lymphocyte count (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Neutrophil count (
32888494
)
Red cell distribution width (
32888494
)
Reticulocyte count (
27863252
32888494
)
Reticulocyte fraction of red cells (
27863252
32888494
)
White blood cell count (
32888494
)
Granulocyte count (
27863252
)
Height (
18391951
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloid white cell count (
27863252
)
Neutrophil count (
27863252
32888494
)
Platelet count (
32888494
)
Refractive error (
32231278
)
Serum thyroid-stimulating hormone levels (
24852370
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systemic lupus erythematosus (
28714469
)
White blood cell count (
29403010
27863252
32888494
)
Interacting Genes
12 interacting genes:
BIRC3
CTNND2
CTSB
EP300
FYN
LYN
MBTPS1
RARG
RPS6KC1
SPHKAP
TRAF2
TRAF6
124 interacting genes:
ACTB
ADAM15
AR
BANK1
BCAR1
BTK
CASP3
CASP7
CASP9
CBL
CBLC
CD19
CD22
CD36
CD72
CD79A
CD79B
CDK1
CDK2
CDKN1B
CHST15
COASY
CREBBP
CRKL
CSF1R
CSF2RA
CSF2RB
CSF3R
CSK
CSNK2B
CTLA4
DAPP1
DLG4
DOK1
DOK2
DOK3
EGFR
EPOR
ERBB3
ERBB4
EVL
FASLG
FCAR
FCER1G
FCGR2A
FCGR2B
FOLR1
GAB2
GAB3
GP6
GRIA3
HCLS1
HNRNPK
IGHA1
IL1B
IL2RB
IL7R
INPP5D
ITPR1
JAK2
KHDRBS1
KIT
LCP2
LIME1
MAP4K1
MAPK3
MATK
MET
MME
MS4A1
MS4A2
MUC1
NDFIP2
NEDD9
NMT1
NPHS1
PAG1
PAK2
PDE4A
PDE4D
PECAM1
PIK3CG
PILRB
PLCG1
PLCG2
PPP1R15A
PPP1R8
PRAM1
PRKCD
PRKCQ
PRKDC
PRRG4
PTK2
PTK2B
PTPN6
PTPRC
RASA1
RGS16
RPL10
RPS6KB1
RPS6KB2
SH2B2
SHC1
SKAP1
SKAP2
SLC4A1
SNCA
SOCS1
SPHK1
SPHK2
STAT3
SYK
TEC
TNF
TRAT1
TRIM28
TRIM55
TRIM63
TRIP10
TRPV4
TYK2
UBB
UHRF2
UNC119
Entrez ID
8877
4067
HPRD ID
04768
01301
Ensembl ID
ENSG00000176170
ENSG00000254087
Uniprot IDs
Q53ZR5
Q9NYA1
A8K379
B4DQ79
P07948
Q6NUK7
PDB IDs
3VZB
3VZC
3VZD
4L02
4V24
1W1F
1WA7
3A4O
5XY1
6NMW
8WFF
Enriched GO Terms of Interacting Partners
?
Stimulatory C-type Lectin Receptor Signaling Pathway
Cellular Response To Lectin
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Regulation Of Protein Modification Process
Regulation Of Innate Immune Response
Tumor Necrosis Factor-mediated Signaling Pathway
Intracellular Signal Transduction
Canonical NF-kappaB Signal Transduction
Innate Immune Response-activating Signaling Pathway
Fc Receptor Signaling Pathway
Activation Of Innate Immune Response
Regulation Of MAP Kinase Activity
Cell Surface Receptor Signaling Pathway
Cellular Response To Oxygen-containing Compound
CD40 Signaling Pathway
Interleukin-17-mediated Signaling Pathway
Regulation Of Apoptotic Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
CD40 Receptor Complex
Regulation Of Immune Response
Regulation Of Programmed Cell Death
Positive Regulation Of T Cell Activation
Positive Regulation Of JUN Kinase Activity
Leukocyte Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
TORC2 Signaling
Regulation Of Immune System Process
Positive Regulation Of Innate Immune Response
Cytoplasmic Side Of Plasma Membrane
Positive Regulation Of DNA-binding Transcription Factor Activity
Cell Activation
Positive Regulation Of Intracellular Signal Transduction
Response To Amino Acid
Positive Regulation Of Immune Response
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Cell-cell Adhesion
Regulation Of Protein Serine/threonine Kinase Activity
Transferase Activity
Signal Transduction
Protein-containing Complex Binding
Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
Positive Regulation Of Cell Projection Organization
Positive Regulation Of Adaptive Immune Response
Immune Response-activating Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of Leukocyte Cell-cell Adhesion
Cell Surface Receptor Signaling Pathway
Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Immune System Process
Immune Response-regulating Signaling Pathway
Immune System Process
Regulation Of Immune Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Plasma Membrane
Antigen Receptor-mediated Signaling Pathway
Regulation Of Programmed Cell Death
Immune Response-activating Signaling Pathway
Positive Regulation Of Immune Response
Regulation Of Apoptotic Process
Intracellular Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Activation Of Immune Response
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
B Cell Receptor Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Adaptive Immune Response
Positive Regulation Of Cell Population Proliferation
Cytokine-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Cell Activation
Immune Response
T Cell Receptor Signaling Pathway
Protein Kinase Activity
Negative Regulation Of Programmed Cell Death
Kinase Activity
Phosphorylation
Protein Phosphorylation
Regulation Of Multicellular Organismal Process
B Cell Activation
Regulation Of Transport
Intracellular Signaling Cassette
Negative Regulation Of Apoptotic Process
Cell Activation
Regulation Of MAPK Cascade
External Side Of Plasma Membrane
Leukocyte Activation
Regulation Of Leukocyte Proliferation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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