SPHK1 and BIRC3

Number of citations of the paper that reports this interaction (PubMedID 24464131)
50

Data Source:
BioGRID (pull down)

		SPHK1	BIRC3
Description		sphingosine kinase 1	baculoviral IAP repeat containing 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Cilium Endosome Membrane Membrane Endocytic Vesicle Cytoplasmic Vesicle Early Endosome Membrane Intracellular Membrane-bounded Organelle Synapse Presynapse	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Lipid Kinase Activity DNA Binding Protein Binding Calmodulin Binding ATP Binding Lipid Binding Sphingosine Kinase Activity Kinase Activity Acetyltransferase Activity Transferase Activity Sphingosine-1-phosphate Receptor Activity Protein Phosphatase 2A Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Blood Vessel Development Sphingosine-1-phosphate Receptor Signaling Pathway Protein Acetylation Lipid Metabolic Process Sphingosine Metabolic Process Inflammatory Response Brain Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Calcium-mediated Signaling Regulation Of Endocytosis Sphingolipid Biosynthetic Process Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-17 Production Regulation Of Amide Metabolic Process Response To Tumor Necrosis Factor Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Smooth Muscle Contraction Sphingosine Biosynthetic Process Sphingoid Catabolic Process Regulation Of Lipid Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Phagocytosis Regulation Of Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Multicellular Organismal Process Cellular Response To Hydrogen Peroxide Cellular Response To Growth Factor Stimulus DNA Biosynthetic Process Sphingolipid Mediated Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Microglial Cell Activation Regulation Of Endosomal Vesicle Fusion	Apoptotic Process Cell Surface Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Spermatogenesis Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of RIG-I Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Regulation Of Inflammatory Response Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Pathways		Sphingolipid de novo biosynthesis Association of TriC/CCT with target proteins during biosynthesis VEGFR2 mediated cell proliferation Extra-nuclear estrogen signaling PKR-mediated signaling	NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte count ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) White blood cell count ( 32888494)	Prostate cancer ( 23535732) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		12 interacting genes: BIRC3 CTNND2 CTSB EP300 FYN LYN MBTPS1 RARG RPS6KC1 SPHKAP TRAF2 TRAF6	37 interacting genes: BIRC5 CASP3 CASP7 CASP9 CD40 CTBP2 CYFIP2 DIABLO DZIP3 GLMN GSPT1 HAX1 HTRA2 IKBKE MAP3K14 MBTPS1 PACS2 PELI1 RAF1 RCHY1 RIPK3 RIPK4 SNX7 SPHK1 SUMO1 TRAF1 TRAF2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2Q2 UBE2V1 USP19 YOD1
Entrez ID		8877	330
HPRD ID		04768	03426
Ensembl ID		ENSG00000176170	ENSG00000023445
Uniprot IDs		Q53ZR5 Q9NYA1	Q13489
PDB IDs		3VZB 3VZC 3VZD 4L02 4V24	2UVL 3EB5 3EB6 3M0A 3M0D 7NK0
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Modification Process Regulation Of Innate Immune Response Tumor Necrosis Factor-mediated Signaling Pathway Intracellular Signal Transduction Canonical NF-kappaB Signal Transduction Innate Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of MAP Kinase Activity Cell Surface Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Regulation Of Apoptotic Process Immune Response-activating Cell Surface Receptor Signaling Pathway CD40 Receptor Complex Regulation Of Immune Response Regulation Of Programmed Cell Death Positive Regulation Of T Cell Activation Positive Regulation Of JUN Kinase Activity Leukocyte Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway TORC2 Signaling Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Cell Activation Positive Regulation Of Intracellular Signal Transduction Response To Amino Acid Positive Regulation Of Immune Response Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Protein Serine/threonine Kinase Activity Transferase Activity Signal Transduction Protein-containing Complex Binding Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Cell Projection Organization Positive Regulation Of Adaptive Immune Response Immune Response-activating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion	Post-translational Protein Modification Protein Modification Process Ubiquitin Conjugating Enzyme Activity Protein Metabolic Process Protein Modification By Small Protein Conjugation Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity CD40 Receptor Complex Protein Polyubiquitination Proteolysis Cytosol Ubiquitin Protein Ligase Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Programmed Cell Death Cell Death Protein Ubiquitination Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cellular Response To Stress Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Ubiquitination Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Catabolic Process Transferase Activity Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Regulation Of Primary Metabolic Process Positive Regulation Of Signaling Positive Regulation Of Post-translational Protein Modification Apoptotic Signaling Pathway Protein Catabolic Process DNA Damage Response Regulation Of Metabolic Process Regulation Of Programmed Cell Death Fibroblast Apoptotic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Response To Stress Intrinsic Apoptotic Signaling Pathway Protein K48-linked Ubiquitination Regulation Of Protein Ubiquitination Neuron Apoptotic Process Regulation Of Signal Transduction
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