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SPHK1
Description
sphingosine kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Cilium
Endosome Membrane
Membrane
Endocytic Vesicle
Cytoplasmic Vesicle
Early Endosome Membrane
Intracellular Membrane-bounded Organelle
Synapse
Presynapse
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Lipid Kinase Activity
DNA Binding
Protein Binding
Calmodulin Binding
ATP Binding
Lipid Binding
Sphingosine Kinase Activity
Kinase Activity
Acetyltransferase Activity
Transferase Activity
Sphingosine-1-phosphate Receptor Activity
Protein Phosphatase 2A Binding
Biological Process
Blood Vessel Development
Sphingosine-1-phosphate Receptor Signaling Pathway
Protein Acetylation
Lipid Metabolic Process
Sphingosine Metabolic Process
Inflammatory Response
Brain Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Regulation Of Gene Expression
Positive Regulation Of Peptidyl-threonine Phosphorylation
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Calcium-mediated Signaling
Regulation Of Endocytosis
Sphingolipid Biosynthetic Process
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Ubiquitination
Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-17 Production
Regulation Of Amide Metabolic Process
Response To Tumor Necrosis Factor
Intracellular Signal Transduction
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Negative Regulation Of Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Smooth Muscle Contraction
Sphingosine Biosynthetic Process
Sphingoid Catabolic Process
Regulation Of Lipid Biosynthetic Process
Positive Regulation Of Fibroblast Proliferation
Regulation Of Phagocytosis
Regulation Of Transport
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Multicellular Organismal Process
Cellular Response To Hydrogen Peroxide
Cellular Response To Growth Factor Stimulus
DNA Biosynthetic Process
Sphingolipid Mediated Signaling Pathway
Regulation Of Neuroinflammatory Response
Negative Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Regulation Of Microglial Cell Activation
Regulation Of Endosomal Vesicle Fusion
Pathways
Sphingolipid de novo biosynthesis
Association of TriC/CCT with target proteins during biosynthesis
VEGFR2 mediated cell proliferation
Extra-nuclear estrogen signaling
PKR-mediated signaling
Drugs
Diseases
GWAS
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Immature fraction of reticulocytes (
32888494
27863252
)
Lymphocyte count (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Neutrophil count (
32888494
)
Red cell distribution width (
32888494
)
Reticulocyte count (
27863252
32888494
)
Reticulocyte fraction of red cells (
27863252
32888494
)
White blood cell count (
32888494
)
Novel Interacting Genes
1 novel interacting genes:
KCTD17
Interacting Genes
12 interacting genes:
BIRC3
CTNND2
CTSB
EP300
FYN
LYN
MBTPS1
RARG
RPS6KC1
SPHKAP
TRAF2
TRAF6
Entrez ID
8877
HPRD ID
04768
Ensembl ID
ENSG00000176170
Uniprot IDs
Q53ZR5
Q9NYA1
PDB IDs
3VZB
3VZC
3VZD
4L02
4V24
Enriched GO Terms of Interacting Partners
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Stimulatory C-type Lectin Receptor Signaling Pathway
Cellular Response To Lectin
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Regulation Of Protein Modification Process
Regulation Of Innate Immune Response
Tumor Necrosis Factor-mediated Signaling Pathway
Intracellular Signal Transduction
Canonical NF-kappaB Signal Transduction
Innate Immune Response-activating Signaling Pathway
Fc Receptor Signaling Pathway
Activation Of Innate Immune Response
Regulation Of MAP Kinase Activity
Cell Surface Receptor Signaling Pathway
Cellular Response To Oxygen-containing Compound
CD40 Signaling Pathway
Interleukin-17-mediated Signaling Pathway
Regulation Of Apoptotic Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
CD40 Receptor Complex
Regulation Of Immune Response
Regulation Of Programmed Cell Death
Positive Regulation Of T Cell Activation
Positive Regulation Of JUN Kinase Activity
Leukocyte Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
TORC2 Signaling
Regulation Of Immune System Process
Positive Regulation Of Innate Immune Response
Cytoplasmic Side Of Plasma Membrane
Positive Regulation Of DNA-binding Transcription Factor Activity
Cell Activation
Positive Regulation Of Intracellular Signal Transduction
Response To Amino Acid
Positive Regulation Of Immune Response
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Cell-cell Adhesion
Regulation Of Protein Serine/threonine Kinase Activity
Transferase Activity
Signal Transduction
Protein-containing Complex Binding
Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
Positive Regulation Of Cell Projection Organization
Positive Regulation Of Adaptive Immune Response
Immune Response-activating Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of Leukocyte Cell-cell Adhesion
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