APLN and PLSCR4

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		APLN	PLSCR4
Description		apelin	phospholipid scramblase 4
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm	Nucleus Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Hormone Activity Apelin Receptor Binding Identical Protein Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding CD4 Receptor Binding
	Biological Process	Angiogenesis Regulation Of The Force Of Heart Contraction G Protein-coupled Receptor Internalization Negative Regulation Of Systemic Arterial Blood Pressure Immune Response Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gastrulation Lactation Feeding Behavior Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Positive Regulation Of Heat Generation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Drinking Behavior Negative Regulation Of Blood Pressure Positive Regulation Of Heart Contraction Negative Regulation Of Vasoconstriction Regulation Of Body Fluid Levels Positive Regulation Of Corticotropin Secretion Positive Regulation Of Corticotropin-releasing Hormone Secretion Apelin Receptor Signaling Pathway Coronary Vasculature Development Positive Regulation Of MiRNA Transcription Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Endothelial Cell Proliferation	Plasma Membrane Phospholipid Scrambling Calcium Activated Phosphatidylserine Scrambling Calcium Activated Phosphatidylcholine Scrambling Cellular Response To Lipopolysaccharide
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases
GWAS			Femur bone mineral density x serum urate levels interaction ( 34046847) Lymphocyte count ( 32888494)
Interacting Genes		8 interacting genes: APLNR GET3 MDFI PLSCR4 PSMA3 RBPMS TRIM55 TRIM63	63 interacting genes: ABHD17A ADAMTSL4 APLN ATP23 CES1 CFAP68 CLPP CRCT1 DAZAP2 DDIT4L EFEMP2 FCHO1 GATA1 HDHD3 HOXA1 INTS11 ITGB4 KLHL38 KPRP KRT82 KRTAP1-5 KRTAP10-8 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP3-1 KRTAP3-3 KRTAP4-12 KRTAP4-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LCE1A LCE1C LCE2B LCE5A LPXN MTUS2 NID2 NOTCH2NLA OXER1 PCSK5 PLA2G10 PLSCR1 RAMAC RBP3 RBPMS RPS27A SLC15A2 SSC4D TEKT5 TENM4 TRIM42 TRIP13 TSPAN4 UBA52 UBB UBC YPEL3 ZNF34
Entrez ID		8862	57088
HPRD ID		02246	07401
Ensembl ID		ENSG00000171388	ENSG00000114698
Uniprot IDs		Q9ULZ1	E9PHR9 Q9NRQ2
PDB IDs		8XQE 8XQF 8XZG 8XZH 8XZJ	3Q5U
Enriched GO Terms of Interacting Partners?		Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Muscle Hypertrophy Mechanoreceptor Activity Apelin Receptor Activity Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Apelin Receptor Signaling Pathway Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of G Protein-coupled Receptor Internalization GET Complex Calcium Activated Phosphatidylserine Scrambling MRNA CDS Binding Calcium Activated Phosphatidylcholine Scrambling Calcium Activated Phospholipid Scrambling Venous Blood Vessel Development Skeletal Muscle Atrophy	Intermediate Filament Keratinization Keratin Filament Protein Tag Activity Endocytic Vesicle Membrane Epidermis Development Protein Binding Female Meiosis I
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