APLN and APLNR

Number of citations of the paper that reports this interaction (PMID 12603839)
36

Data Source:
HPRD (in vivo)

		APLN	APLNR
Gene Name		apelin	apelin receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Hormone Activity Apelin Receptor Binding	Receptor Activity G-protein Coupled Receptor Activity
	Biological Process	Immune Response Signal Transduction Lactation Signaling	G-protein Coupled Receptor Signaling Pathway Gastrulation Heart Development Regulation Of Body Fluid Levels
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APLNR ASNA1 MDFI PSMA3 RBPMS	1 interactors: APLN
Entrez ID		8862	187
HPRD ID		02246	02503
Ensembl ID		ENSG00000171388	ENSG00000134817
Uniprot IDs		Q9ULZ1	B2RDH3 B3KQN4 P35414
PDB IDs			2LOT 2LOU 2LOV 2LOW
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Modification Process Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Protein Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Protein Insertion Into ER Membrane Regulation Of Wnt Signaling Pathway Positive Regulation Of SMAD Protein Import Into Nucleus	Lactation Body Fluid Secretion
Tagcloud ?		accompaniment annotation bx captures caveats discriminatory edu employ fam156a fam156b filtering freely galaxy lda maged4 maged4b orientated pertinent plausibility plausible prioritization psu ranked rap2c refine tbl1x uxt xlmr zc4h2	alleles always bdkrb2 bp dbp diastolic dissection equations estimating generalized genotypes gnb3 guanine homogenous inactive minor modifies nongenetic nr3c2 physically polypeptide reductions rural sbp scnn1b snp snps variants villagers
Tagcloud (Difference) ?		accompaniment annotation bx captures caveats discriminatory edu employ fam156a fam156b filtering freely galaxy lda maged4 maged4b orientated pertinent plausibility plausible prioritization psu ranked rap2c refine tbl1x uxt xlmr zc4h2	alleles always bdkrb2 bp dbp diastolic dissection equations estimating generalized genotypes gnb3 guanine homogenous inactive minor modifies nongenetic nr3c2 physically polypeptide reductions rural sbp scnn1b snp snps variants villagers
Tagcloud (Intersection) ?