APLN

Description		apelin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm
	Molecular Function	Signaling Receptor Binding Hormone Activity Apelin Receptor Binding Identical Protein Binding
	Biological Process	Angiogenesis Regulation Of The Force Of Heart Contraction G Protein-coupled Receptor Internalization Negative Regulation Of Systemic Arterial Blood Pressure Immune Response Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gastrulation Lactation Feeding Behavior Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Positive Regulation Of Heat Generation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Drinking Behavior Negative Regulation Of Blood Pressure Positive Regulation Of Heart Contraction Negative Regulation Of Vasoconstriction Regulation Of Body Fluid Levels Positive Regulation Of Corticotropin Secretion Positive Regulation Of Corticotropin-releasing Hormone Secretion Apelin Receptor Signaling Pathway Coronary Vasculature Development Positive Regulation Of MiRNA Transcription Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Endothelial Cell Proliferation
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases
GWAS
Interacting Genes		8 interacting genes: APLNR GET3 MDFI PLSCR4 PSMA3 RBPMS TRIM55 TRIM63
Entrez ID		8862
HPRD ID		02246
Ensembl ID		ENSG00000171388
Uniprot IDs		Q9ULZ1
PDB IDs		8XQE 8XQF 8XZG 8XZH 8XZJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Muscle Hypertrophy Mechanoreceptor Activity Apelin Receptor Activity Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Apelin Receptor Signaling Pathway Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of G Protein-coupled Receptor Internalization GET Complex Calcium Activated Phosphatidylserine Scrambling MRNA CDS Binding Calcium Activated Phosphatidylcholine Scrambling Calcium Activated Phospholipid Scrambling Venous Blood Vessel Development Skeletal Muscle Atrophy
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