ASAP2 and ITSN1

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		ASAP2	ITSN1
Gene Name		ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	intersectin 1 (SH3 domain protein)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Golgi Cisterna Membrane	Cytosol Plasma Membrane Coated Pit Lamellipodium Cell Junction Endocytic Vesicle Neuron Projection Synapse
	Molecular Function	Protein Binding Enzyme Activator Activity ARF GTPase Activator Activity Zinc Ion Binding	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Kinase Activator Activity Protein Complex Scaffold Proline-rich Region Binding
	Biological Process	Regulation Of ARF GTPase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway
Pathways			Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHB-mediated forward signaling GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ARF1 ARF5 ARF6 BIN1 GRB2 ITSN1 PACSIN3 PTK2B PXN RAN REPS2 SH3KBP1 THSD7A	82 interactors: AGFG1 AGFG2 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHSD2 FNBP1 FNBP4 GAREML GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 RAB11FIP2 RAB5A RABEP1 RAI14 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SH3GL2 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 WASL WBP11 ZAK ZFPM2
Entrez ID		8853	6453
HPRD ID		04820	03898
Ensembl ID		ENSG00000151693	ENSG00000205726
Uniprot IDs		O43150	A7XZY7 F8W7U0 Q15811 Q6PD56
PDB IDs			1KI1 2KGR 2KHN 3FIA 3QBV 4IIM
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Endocytosis Enzyme Linked Receptor Protein Signaling Pathway Cytoskeleton Organization Cell Projection Organization Endocytosis Intracellular Signal Transduction Transport Positive Regulation Of Actin Filament Polymerization Signal Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Polymerization Regulation Of Vesicle-mediated Transport Signal Transduction Regulation Of Actin Filament-based Process Movement Of Cell Or Subcellular Component Signaling Regulation Of Cell Shape Cell Communication Focal Adhesion Assembly Positive Regulation Of Protein Complex Assembly Cell Differentiation Regulation Of Actin Filament Polymerization Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Viral Process Regulation Of Actin Filament Length Adherens Junction Assembly Negative Regulation Of Endocytosis Cell-substrate Junction Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Response To Stimulus Regulation Of Signaling Organelle Organization Positive Regulation Of Cellular Component Biogenesis Establishment Of Organelle Localization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Adherens Junction Organization Positive Regulation Of Metabolic Process Generation Of Neurons	Vesicle-mediated Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Endocytosis Vesicle Organization Cellular Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Signaling Synaptic Transmission Regulation Of Cellular Component Organization Establishment Of Organelle Localization Cell Communication Regulation Of Signaling Organelle Organization Protein Localization Cell Differentiation Synaptic Vesicle Transport Cell-cell Signaling Membrane Budding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Localization Regulation Of ERBB Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Establishment Of Vesicle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vesicle Localization Transport Cell Morphogenesis Involved In Neuron Differentiation Axon Guidance Generation Of Neurons Cell Morphogenesis Involved In Differentiation Membrane Organization Cell Projection Morphogenesis Cell Part Morphogenesis Establishment Of Protein Localization Cell Projection Organization Synaptic Vesicle Recycling Axonogenesis Cellular Protein Complex Assembly Neurogenesis Regulation Of Catalytic Activity Regulation Of Signal Transduction Intracellular Transport Cell Morphogenesis
Tagcloud ?		affy cdkn2a coexpressed coexpression constructed contructed david degs differential differentially disturbed dlk1 downloaded enrichment exploring gse26966 hub inositol itga4 mpp2 network networks obvious omnibus package phosphatidylinositol pituitary screened software	cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3
Tagcloud (Difference) ?		affy cdkn2a coexpressed coexpression constructed contructed differential differentially disturbed dlk1 enrichment exploring gse26966 hub inositol itga4 mpp2 network networks obvious omnibus package phosphatidylinositol pituitary screened software	cbr1 dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3
Tagcloud (Intersection) ?		david degs downloaded