ASAP2 and RAN

Number of citations of the paper that reports this interaction (PMID 10022920)
27

Data Source:
HPRD (in vivo)

		ASAP2	RAN
Gene Name		ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	RAN, member RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Golgi Cisterna Membrane	Chromatin Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Melanosome Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Enzyme Activator Activity ARF GTPase Activator Activity Zinc Ion Binding	Chromatin Binding Transcription Coactivator Activity GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Poly(A) RNA Binding Androgen Receptor Binding
	Biological Process	Regulation Of ARF GTPase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus DNA Metabolic Process Protein Import Into Nucleus Protein Export From Nucleus Mitotic Spindle Organization Mitotic Nuclear Division Signal Transduction Small GTPase Mediated Signal Transduction Spermatid Development Gene Expression Viral Process Viral Life Cycle Actin Cytoskeleton Organization Androgen Receptor Signaling Pathway Positive Regulation Of Protein Binding Cellular Protein Complex Localization Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Cell Division Intracellular Transport Of Virus
Pathways			Transcriptional regulation by small RNAs Metabolism of lipids and lipoproteins Nuclear import of Rev protein HIV Infection Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Host Interactions of HIV factors MicroRNA (miRNA) biogenesis Influenza Infection Interactions of Rev with host cellular proteins Late Phase of HIV Life Cycle Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Export of Viral Ribonucleoproteins from Nucleus HIV Life Cycle Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ARF1 ARF5 ARF6 BIN1 GRB2 ITSN1 PACSIN3 PTK2B PXN RAN REPS2 SH3KBP1 THSD7A	55 interactors: ABL1 ADRB2 AR ASAP2 BCAR1 BMPR1B CSE1L EP300 GADD45G GIT1 IPO11 IPO13 IPO5 IPO7 KIAA1377 KPNA2 KPNB1 MBP MSL1 NEK9 NR3C1 NSMF NUP153 NUP50 NUPR1 NUTF2 NXF1 NXT1 PAK4 PTMA RANBP1 RANBP10 RANBP2 RANBP3 RANBP9 RANGAP1 RANGRF RCC1 RGPD5 RPL7 SMAD1 SMAD2 SMARCB1 SMURF2 SNUPN SPAG8 SSRP1 TGFBR1 TNPO1 TNPO2 XPO1 XPO4 XPO5 XPO7 XPOT
Entrez ID		8853	5901
HPRD ID		04820	03109
Ensembl ID		ENSG00000151693
Uniprot IDs		O43150	B4DV51 P62826
PDB IDs			1I2M 1IBR 1K5D 1K5G 1QBK 1RRP 3CH5 3EA5 3GJ0 3GJ3 3GJ4 3GJ5 3GJ6 3GJ7 3GJ8 3GJX 3NBY 3NBZ 3NC0 3NC1 3ZJY 4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3 4HB4
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Endocytosis Enzyme Linked Receptor Protein Signaling Pathway Cytoskeleton Organization Cell Projection Organization Endocytosis Intracellular Signal Transduction Transport Positive Regulation Of Actin Filament Polymerization Signal Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Polymerization Regulation Of Vesicle-mediated Transport Signal Transduction Regulation Of Actin Filament-based Process Movement Of Cell Or Subcellular Component Signaling Regulation Of Cell Shape Cell Communication Focal Adhesion Assembly Positive Regulation Of Protein Complex Assembly Cell Differentiation Regulation Of Actin Filament Polymerization Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Viral Process Regulation Of Actin Filament Length Adherens Junction Assembly Negative Regulation Of Endocytosis Cell-substrate Junction Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Response To Stimulus Regulation Of Signaling Organelle Organization Positive Regulation Of Cellular Component Biogenesis Establishment Of Organelle Localization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Adherens Junction Organization Positive Regulation Of Metabolic Process Generation Of Neurons	Nucleocytoplasmic Transport Nuclear Transport Cytoplasmic Transport Intracellular Transport Protein Transport Establishment Of Protein Localization Establishment Of Localization In Cell Intracellular Protein Transport Nuclear Import Protein Localization Cellular Localization Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cellular Protein Localization Protein Import Establishment Of Protein Localization To Organelle RNA Transport RNA Localization Protein Localization To Organelle Protein Targeting Protein Export From Nucleus Nuclear Export Transport Ribosomal Protein Import Into Nucleus Positive Regulation Of Ran GTPase Activity Viral Life Cycle MRNA Transport Cellular Response To Organic Substance Mitotic Cell Cycle Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly NLS-bearing Protein Import Into Nucleus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Organic Substance Regulation Of Nucleocytoplasmic Transport Cell Cycle Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Process Nuclear Envelope Organization Mitotic Cell Cycle Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Export From Nucleus Intracellular Transport Of Virus Regulation Of Intracellular Transport Cellular Response To Transforming Growth Factor Beta Stimulus Viral Transcription
Tagcloud ?		affy cdkn2a coexpressed coexpression constructed contructed david degs differential differentially disturbed dlk1 downloaded enrichment exploring gse26966 hub inositol itga4 mpp2 network networks obvious omnibus package phosphatidylinositol pituitary screened software	5a accessible actually arginine bandshift bi cargo characterised directional dissociated export exports gtpase heterodimer import imported importin localisation masks multimeric nes nls nucleoplasm overlaps rab rev rip shuttle unspliced
Tagcloud (Difference) ?		affy cdkn2a coexpressed coexpression constructed contructed david degs differential differentially disturbed dlk1 downloaded enrichment exploring gse26966 hub inositol itga4 mpp2 network networks obvious omnibus package phosphatidylinositol pituitary screened software	5a accessible actually arginine bandshift bi cargo characterised directional dissociated export exports gtpase heterodimer import imported importin localisation masks multimeric nes nls nucleoplasm overlaps rab rev rip shuttle unspliced
Tagcloud (Intersection) ?