GGH and SGTB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GGH	SGTB
Description		gamma-glutamyl hydrolase	small glutamine rich tetratricopeptide repeat co-chaperone beta
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Lysosome Vacuole Azurophil Granule Lumen Specific Granule Lumen Melanosome Extracellular Exosome Tertiary Granule Lumen	Membrane TRC Complex
	Molecular Function	Protein Binding Exopeptidase Activity Omega Peptidase Activity Hydrolase Activity Gamma-glutamyl-peptidase Activity	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity
	Biological Process	Tetrahydrofolylpolyglutamate Metabolic Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		2 interacting genes: LIG4 SGTB	116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B
Entrez ID		8836	54557
HPRD ID		03299	18049
Ensembl ID		ENSG00000137563	ENSG00000197860
Uniprot IDs		A0A7I2V5X9 Q92820	Q96EQ0
PDB IDs		1L9X
Enriched GO Terms of Interacting Partners?		Establishment Of Integrated Proviral Latency DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency T Cell Differentiation Central Nervous System Development DNA Ligase Activity DN2 Thymocyte Differentiation TRC Complex Olfactory Nerve Development Right Ventricular Compact Myocardium Morphogenesis Right Ventricular Cardiac Muscle Tissue Morphogenesis Ear Morphogenesis Double-strand Break Repair Via Classical Nonhomologous End Joining Lymphoid Progenitor Cell Differentiation Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development DNA-dependent Protein Kinase-DNA Ligase 4 Complex Single Strand Break Repair Immunoglobulin V(D)J Recombination AMP Binding Lymphocyte Differentiation Chordate Embryonic Development Nonhomologous End Joining Complex Nucleotide-excision Repair, DNA Gap Filling In Utero Embryonic Development T Cell Activation Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Secondary Palate Development Regulation Of Growth Hormone Secretion Semicircular Canal Morphogenesis Ventricular Compact Myocardium Morphogenesis Adult Heart Development Olfactory Behavior Atrioventricular Canal Development Nose Development Phosphatidylinositol Bisphosphate Binding N6-methyladenosine-containing RNA Reader Activity Ventricular Trabecula Myocardium Morphogenesis Cellular Response To Lithium Ion Mononuclear Cell Differentiation Response To Lithium Ion Regulation Of Metal Ion Transport Female Genitalia Development Chemosensory Behavior Regulation Of Trophoblast Cell Migration	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion
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