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SOCS2 and GHR
Number of citations of the paper that reports this interaction (PubMedID
10585430
)
0
Data Source:
HPRD
(in vitro, in vivo)
SOCS2
GHR
Description
suppressor of cytokine signaling 2
growth hormone receptor
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cul5-RING Ubiquitin Ligase Complex
Extracellular Region
Extracellular Space
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Cytoplasmic Ribonucleoprotein Granule
Neuronal Cell Body
Receptor Complex
Growth Hormone Receptor Complex
Molecular Function
Cytokine Receptor Binding
Growth Hormone Receptor Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
JAK Pathway Signal Transduction Adaptor Activity
Phosphorylation-dependent Protein Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Cytokine Receptor Activity
Growth Hormone Receptor Activity
Protein Binding
Lipid Binding
Peptide Hormone Binding
Growth Factor Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cytokine Binding
Protein Tyrosine Kinase Activator Activity
SH2 Domain Binding
Identical Protein Binding
Protein Homodimerization Activity
Proline-rich Region Binding
Protein Tyrosine Kinase Binding
Biological Process
Regulation Of Cell Growth
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Lactation
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Response To Estradiol
Cellular Response To Hormone Stimulus
Intracellular Signal Transduction
Erythropoietin-mediated Signaling Pathway
Regulation Of Multicellular Organism Growth
Negative Regulation Of Multicellular Organism Growth
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Growth Hormone Receptor Signaling Pathway
Mammary Gland Alveolus Development
Endocytosis
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Population Proliferation
Response To Gravity
Response To Hormone
Hormone-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Receptor Internalization
Response To Food
Regulation Of Response To Nutrient Levels
Response To Estradiol
Cellular Response To Insulin Stimulus
Cellular Response To Hormone Stimulus
Response To Cytokine
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Hormone Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of MAPK Cascade
Response To Peptide Hormone
Positive Regulation Of Cell Differentiation
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Response To Cycloheximide
Insulin-like Growth Factor Receptor Signaling Pathway
Response To Glucocorticoid
Cartilage Development Involved In Endochondral Bone Morphogenesis
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Growth Hormone Receptor Signaling Pathway
Response To Growth Hormone
Response To Interleukin-1
Pathways
Interleukin-7 signaling
Neddylation
Negative regulation of FLT3
Growth hormone receptor signaling
Prolactin receptor signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Drugs
Somatotropin
Pegvisomant
Somatrem
Somapacitan
Lonapegsomatropin
Diseases
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Height (
18391951
18391952
20881960
23563607
25282103
25429064
28552196
31562340
)
Hepatic lipid content in extreme obesity (
25246029
)
Hip circumference adjusted for BMI (
34021172
)
Joint damage in rheumatoid arthritis (
31596875
)
Pubertal anthropometrics (
23449627
)
Type 2 diabetes (
30054458
)
Appendicular lean mass (
33097823
)
Blood protein levels (
30072576
)
Familial squamous cell lung carcinoma (
29924316
)
Heel bone mineral density (
30598549
)
Height (
25429064
28552196
31562340
)
Hip circumference adjusted for BMI (
34021172
)
Iron status biomarkers (
19084217
)
Menarche (age at onset) (
25231870
)
Plasma renin activity levels (
29650764
)
Response to taxane treatment (docetaxel) (
23006423
)
Systemic lupus erythematosus (
18204098
)
Interacting Genes
21 interacting genes:
ARFIP2
BMI1
EGFR
EPOR
ERBB3
ERBB4
GHR
IGF1R
INSR
JAK1
JAK3
KIT
MET
PLA2G1B
PRLR
PTK2
RYBP
SOCS3
STK16
TPD52
YES1
44 interacting genes:
AP2A1
BTRC
CISH
CUL1
CUL5
DUSP7
ELOB
ELOC
FBXO31
GH1
GH2
GRB10
GRB2
IRS1
JAK1
JAK2
NCOA6
NEDD8
PIK3R1
PIK3R2
PLCG1
PTPN1
PTPN11
PTPN13
PTPN2
PTPN3
PTPN6
PTPN9
PTPRB
PTPRH
RBX1
RNF7
SGTA
SHC1
SKP1
SOCS1
SOCS2
SOCS3
SRPK2
STAT3
STAT5A
STAT5B
STUB1
TYK2
Entrez ID
8835
2690
HPRD ID
05490
02971
Ensembl ID
ENSG00000120833
ENSG00000112964
Uniprot IDs
O14508
A0A087X0H5
A0A087X162
P10912
PDB IDs
2C9W
4JGH
5BO4
6I4X
6I5J
6I5N
7M6T
7ZLM
7ZLN
7ZLO
7ZLP
7ZLR
7ZLS
1A22
1AXI
1HWG
1HWH
1KF9
2AEW
3HHR
5OEK
5OHD
6I5J
6I5N
Enriched GO Terms of Interacting Partners
?
Protein Tyrosine Kinase Activity
Protein Kinase Activity
Receptor Complex
Kinase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Phosphorylation
Phosphorylation
Protein Phosphatase Binding
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Population Proliferation
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Cell Surface Receptor Signaling Pathway Via STAT
ATP Binding
Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Programmed Cell Death
Negative Regulation Of Programmed Cell Death
Peptidyl-tyrosine Phosphorylation
Protein Autophosphorylation
Nucleotide Binding
Transferase Activity
Growth Hormone Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of MAPK Cascade
Protein Modification Process
Regulation Of Cell Population Proliferation
Regulation Of Multicellular Organismal Process
Positive Regulation Of Multicellular Organismal Process
Phosphate-containing Compound Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Cell Differentiation
Regulation Of MAPK Cascade
Protein Tyrosine Kinase Activator Activity
Cellular Developmental Process
Epidermal Growth Factor Receptor Signaling Pathway
Protein Metabolic Process
Positive Regulation Of Metabolic Process
Basal Plasma Membrane
Regulation Of Signal Transduction
Positive Regulation Of Phosphate Metabolic Process
ERBB Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Modification Process
Cytokine-mediated Signaling Pathway
Intracellular Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Phosphotyrosine Residue Binding
Cell Surface Receptor Signaling Pathway Via STAT
Cytosol
Protein Dephosphorylation
Growth Hormone Receptor Binding
Protein Tyrosine Phosphatase Activity
Peptidyl-tyrosine Dephosphorylation
Signal Transduction
Protein Metabolic Process
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Insulin Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Macromolecule Metabolic Process
Cul5-RING Ubiquitin Ligase Complex
Dephosphorylation
Phosphoprotein Phosphatase Activity
Regulation Of Signal Transduction
Negative Regulation Of Growth Hormone Receptor Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Cellular Response To Insulin Stimulus
Protein Ubiquitination
Insulin Receptor Binding
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Cellular Response To Insulin Stimulus
Regulation Of Growth Hormone Receptor Signaling Pathway
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Protein Modification By Small Protein Conjugation
Regulation Of Signaling
Regulation Of Cell Communication
Post-translational Protein Modification
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Regulation Of Cell Adhesion
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Cytoplasm
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Tagcloud (Intersection)
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