SOCS2 and EPOR

Number of citations of the paper that reports this interaction (PubMedID 15644415)
0

Data Source:
HPRD (two hybrid, in vitro)

		SOCS2	EPOR
Description		suppressor of cytokine signaling 2	erythropoietin receptor
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cul5-RING Ubiquitin Ligase Complex	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Nuclear Speck
	Molecular Function	Cytokine Receptor Binding Growth Hormone Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding JAK Pathway Signal Transduction Adaptor Activity Phosphorylation-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Erythropoietin Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Cell Growth Cell Surface Receptor Signaling Pathway Via JAK-STAT Lactation Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Intracellular Signal Transduction Erythropoietin-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Mammary Gland Alveolus Development	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Decidualization
Pathways		Interleukin-7 signaling Neddylation Negative regulation of FLT3 Growth hormone receptor signaling	Signaling by Erythropoietin Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS
Drugs			Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta
Diseases			Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Height ( 18391951 18391952 20881960 23563607 25282103 25429064 28552196 31562340) Hepatic lipid content in extreme obesity ( 25246029) Hip circumference adjusted for BMI ( 34021172) Joint damage in rheumatoid arthritis ( 31596875) Pubertal anthropometrics ( 23449627) Type 2 diabetes ( 30054458)	Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)
Interacting Genes		21 interacting genes: ARFIP2 BMI1 EGFR EPOR ERBB3 ERBB4 GHR IGF1R INSR JAK1 JAK3 KIT MET PLA2G1B PRLR PTK2 RYBP SOCS3 STK16 TPD52 YES1	42 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 RNF128 RNF43 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL ZNRF3
Entrez ID		8835	2057
HPRD ID		05490	00587
Ensembl ID		ENSG00000120833	ENSG00000187266
Uniprot IDs		O14508	P19235
PDB IDs		2C9W 4JGH 5BO4 6I4X 6I5J 6I5N 7M6T 7ZLM 7ZLN 7ZLO 7ZLP 7ZLR 7ZLS	1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6I4X 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL 8VUI 8VVM 8VVO
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Protein Kinase Activity Receptor Complex Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Phosphorylation Protein Phosphatase Binding Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT ATP Binding Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Nucleotide Binding Transferase Activity Growth Hormone Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of MAPK Cascade Protein Modification Process Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Phosphate-containing Compound Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Differentiation Regulation Of MAPK Cascade Protein Tyrosine Kinase Activator Activity Cellular Developmental Process Epidermal Growth Factor Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Metabolic Process Basal Plasma Membrane Regulation Of Signal Transduction Positive Regulation Of Phosphate Metabolic Process ERBB Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process	Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytokine-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Immune Effector Process Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Immune System Process Regulation Of Immune Response Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Cell Communication Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Defense Response Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cell Activation Erythropoietin-mediated Signaling Pathway Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Insulin Receptor Signaling Pathway Phosphorylation-dependent Protein Binding Regulation Of Mononuclear Cell Proliferation Myeloid Cell Differentiation Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of T Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Cell Migration B Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Immune System Process Positive Regulation Of Cell Motility Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Locomotion Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Cytosol Positive Regulation Of Mast Cell Proliferation
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