SOCS2 and EPOR

Number of citations of the paper that reports this interaction (PMID 11781573)
32

Data Source:
HPRD (two hybrid, in vitro)

		SOCS2	EPOR
Gene Name		suppressor of cytokine signaling 2	erythropoietin receptor
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Integral Component Of Plasma Membrane
	Molecular Function	Protein Kinase Inhibitor Activity SH3/SH2 Adaptor Activity Growth Hormone Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding JAK Pathway Signal Transduction Adaptor Activity	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Cell Growth Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Aging Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Decidualization
Pathways		Cytokine Signaling in Immune system Growth hormone receptor signaling
Drugs			Darbepoetin alfa Epoetin alfa 3,5 DIBROMOTYROSINE Peginesatide
Diseases
GWAS		Height ( 20881960 23563607 18391951 18391952) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		12 interactors: ARFIP2 BMI1 EPOR GHR IGF1R INSR PLA2G1B PRLR PTK2 RYBP SOCS3 TPD52	36 interactors: ATXN2L CBL CISH CRKL CSF2RB EPO GAB1 GAB2 GNAI1 GNB2L1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK SYP VAV1
Entrez ID		8835	2057
HPRD ID		05490	00587
Ensembl ID		ENSG00000120833	ENSG00000187266
Uniprot IDs		O14508	P19235
PDB IDs		2C9W 4JGH	1CN4 1EBA 1EBP 1EER 1ERN 2JIX
Enriched GO Terms of Interacting Partners?		Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Response To Growth Hormone Cellular Response To Hormone Stimulus Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Response To Organonitrogen Compound Response To Hormone Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transferase Activity JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Developmental Process Involved In Reproduction Activation Of JAK2 Kinase Activity Peptidyl-tyrosine Autophosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Regulation Of Protein Metabolic Process JAK-STAT Cascade Positive Regulation Of Protein Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Kinase Activity Reproductive Structure Development Peptidyl-amino Acid Modification Reproductive System Development Regulation Of Catalytic Activity Positive Regulation Of DNA Replication Response To Organic Substance Activation Of Janus Kinase Activity Exocrine Pancreas Development Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Metabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Response To Organic Substance Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Intracellular Signal Transduction Cellular Response To Peptide Regulation Of Kinase Activity Fc Receptor Signaling Pathway Response To Peptide Hormone Regulation Of Body Fluid Levels JAK-STAT Cascade Response To Peptide Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Blood Coagulation Regulation Of Immune System Process Hemostasis Innate Immune Response Defense Response Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Regulation Of Signaling Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Protein Kinase Activity ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Hormone Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Wounding Wound Healing Neurotrophin TRK Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response Neurotrophin Signaling Pathway Regulation Of Intracellular Signal Transduction Signaling Cell Communication
Tagcloud ?		abrogation adenomas alcoholic ccl3 col1a2 col3a1 compromised confirming fibrotic fivefold gh ghr ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs3 steatosis superarray tgfbeta threefold tolerance unravel	actual agonist angstrom antagonist apart configuration crystal dimer efficiency erythropoietin far formed hematopoietic homodimerization insights interact ligands mimetic organization peptide permit plasticity preformed recognition resolution spanning thought unliganded
Tagcloud (Difference) ?		abrogation adenomas alcoholic ccl3 col1a2 col3a1 compromised confirming fibrotic fivefold gh ghr ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs3 steatosis superarray tgfbeta threefold tolerance unravel	actual agonist angstrom antagonist apart configuration crystal dimer efficiency erythropoietin far formed hematopoietic homodimerization insights interact ligands mimetic organization peptide permit plasticity preformed recognition resolution spanning thought unliganded
Tagcloud (Intersection) ?