NRP2 and NRP1

Number of citations of the paper that reports this interaction (PubMedID 25315821)
0

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		NRP2	NRP1
Description		neuropilin 2	neuropilin 1
Image
GO Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Axon Postsynaptic Membrane Glutamatergic Synapse	Semaphorin Receptor Complex Extracellular Region Extracellular Space Cytoplasm Mitochondrion Early Endosome Cytosol Neurofilament Plasma Membrane Focal Adhesion Membrane Axon Cytoplasmic Vesicle Mitochondrial Membrane Neuron Projection Receptor Complex Postsynaptic Membrane Sorting Endosome Glutamatergic Synapse
	Molecular Function	Vascular Endothelial Growth Factor Receptor Activity Protein Binding Heparin Binding Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding	Vascular Endothelial Growth Factor Receptor Activity GTPase Activator Activity Protein Binding Heparin Binding Coreceptor Activity Semaphorin Receptor Activity Growth Factor Binding Protein Kinase Binding Cytokine Binding Vascular Endothelial Growth Factor Binding Metal Ion Binding
	Biological Process	Angiogenesis Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Outflow Tract Septum Morphogenesis Cell Adhesion Nervous System Development Axon Guidance Heart Development Positive Regulation Of Endothelial Cell Migration Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Cell Differentiation Trunk Neural Crest Cell Migration Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Sympathetic Ganglion Development Trigeminal Ganglion Development Semaphorin-plexin Signaling Pathway Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Regulation Of Postsynapse Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Cellular Response To Leukemia Inhibitory Factor	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Neural Crest Cell Migration Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Integrin-mediated Signaling Pathway Cell-cell Signaling Nervous System Development Axon Guidance Axonal Fasciculation Heart Development Motor Neuron Axon Guidance Response To Wounding Animal Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Facial Nerve Structural Organization Trigeminal Nerve Morphogenesis Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Cell Differentiation Negative Regulation Of Axon Extension Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Retinal Ganglion Cell Axon Guidance Regulation Of Cdc42 Protein Signal Transduction Cellular Response To Hepatocyte Growth Factor Stimulus Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Neuropilin Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Endothelial Cell Migration Positive Regulation Of Angiogenesis Symbiont Entry Into Host Cell Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Sympathetic Nervous System Development Neuron Development Axon Extension Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Axon Extension Involved In Axon Guidance Positive Chemotaxis Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Axonogenesis Involved In Innervation Regulation Of Vesicle-mediated Transport Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Retina Vasculature Development In Camera-type Eye Retina Vasculature Morphogenesis In Camera-type Eye Renal Artery Morphogenesis Sympathetic Ganglion Development Trigeminal Ganglion Development Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Commissural Neuron Axon Guidance Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Endothelial Tip Cell Fate Specification Sensory Neuron Axon Guidance Motor Neuron Migration Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Postsynapse Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Basal Dendrite Development Basal Dendrite Arborization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neural Crest Cell Migration Involved In Autonomic Nervous System Development Protein Localization To Early Endosome Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Otic Placode Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Neurophilin interactions with VEGF and VEGFR NrCAM interactions	Neurophilin interactions with VEGF and VEGFR Signaling by ROBO receptors Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Signal transduction by L1 CHL1 interactions Attachment and Entry
Drugs		ATYR1923
Diseases
GWAS		Blood protein levels ( 30072576) Craniofacial microsomia ( 26853712) Daytime nap ( 33568662) Diisocyanate-induced asthma ( 25918132) Neuropathy x type 2 diabetes interaction ( 32541925)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Migraine ( 27322543) Reticulocyte count ( 32888494) Schizophrenia ( 21682944) Small cell lung carcinoma ( 28604730) Tetralogy of Fallot ( 23297363) Type 1 diabetes ( 34127860) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: FLT1 L1CAM NRP1 PGF PLXNA1 PLXNB1 SEMA3B SEMA3C SEMA3F SEMA4F VEGFA	27 interacting genes: FGF1 FGF2 FGF4 FGF7 FGFR1 FLT1 GIPC1 KDR L1CAM NRP2 PGF PLXNA1 PLXNB1 RPL27 SEMA3A SEMA3B SEMA3C SEMA3F SNCA SNX5 SNX6 TGFBR1 TGFBR2 TGFBR3 USP9X VEGFA VEGFB
Entrez ID		8828	8829
HPRD ID		03643	03642
Ensembl ID		ENSG00000118257	ENSG00000099250
Uniprot IDs		O60462	A8K9V7 E9PEP6 O14786 Q59F20 Q6X907
PDB IDs		2QQJ 2QQK 2QQL 2QQO 4QDQ 4QDR 4QDS 5DN2 5DQ0 6GH8 6TDB 6TJT 7M22 7T4S 8IVW 8IVX	1KEX 2QQI 2QQM 2QQN 3I97 4DEQ 4RN5 5C7G 5IJR 5IYY 5J1X 5JGI 5JGQ 5JHK 5L73 6FMC 6FMF 6TKK 7JJC 7O1N 7P5U 8C5G 8PFE 9EOU
Enriched GO Terms of Interacting Partners?		Semaphorin-plexin Signaling Pathway Chemotaxis Locomotion Neuron Projection Guidance Neuropilin Binding Semaphorin Receptor Binding Cell Migration Regulation Of Cell Migration Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Axon Guidance Neuron Projection Development Neural Crest Cell Migration Regulation Of Axonogenesis Mesenchymal Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Vascular Endothelial Growth Factor Signaling Pathway Cell Projection Organization Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Regulation Of Axon Extension Chemorepellent Activity Cell Surface Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Sprouting Angiogenesis Plasma Membrane Bounded Cell Projection Organization Negative Chemotaxis Ameboidal-type Cell Migration Regulation Of Neurogenesis Semaphorin Receptor Activity Semaphorin Receptor Complex Regulation Of Neuron Projection Development Regulation Of Nervous System Development Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Axonogenesis Regulation Of Anatomical Structure Morphogenesis Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Developmental Growth Negative Regulation Of Axon Extension Ventral Trunk Neural Crest Cell Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Axon Extension Vascular Endothelial Growth Factor Receptor Binding Sympathetic Neuron Projection Guidance Neuropilin Signaling Pathway	Regulation Of Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Semaphorin-plexin Signaling Pathway Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Heparin Binding Chemotaxis Cell Motility Cell Surface Receptor Signaling Pathway Locomotion Vascular Endothelial Growth Factor Signaling Pathway Tissue Morphogenesis Positive Regulation Of Cell Division Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Regulation Of Chemotaxis Neuropilin Binding Angiogenesis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Region Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Semaphorin Receptor Binding Lung Development Anatomical Structure Morphogenesis Regulation Of Cell Division Positive Regulation Of Vasculature Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Endothelial Cell Migration Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphate Metabolic Process Chemoattractant Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Growth Factor Developmental Growth Involved In Morphogenesis Neuron Projection Guidance Positive Regulation Of MAPK Cascade Morphogenesis Of An Epithelium Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?