NRP2 and SEMA4F

Number of citations of the paper that reports this interaction (PMID 9856463)
49

Data Source:
HPRD (in vitro)

		NRP2	SEMA4F
Gene Name		neuropilin 2	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Integral Component Of Membrane	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Membrane Postsynaptic Membrane
	Molecular Function	Receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Heparin Binding Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Metal Ion Binding	Receptor Activity
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Cell Adhesion Axon Guidance Positive Regulation Of Endothelial Cell Migration Nerve Development Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Extension Involved In Axon Guidance Sympathetic Ganglion Development Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance	Cell-cell Signaling Nervous System Development Axon Guidance Negative Regulation Of Axon Extension Retinal Ganglion Cell Axon Guidance
Pathways		Axon guidance Signaling by VEGF Neurophilin interactions with VEGF and VEGFR L1CAM interactions NrCAM interactions
Drugs
Diseases
GWAS			Myopia (pathological) ( 22685421)
Protein-Protein Interactions		8 interactors: FLT1 NRP1 PGF SEMA3B SEMA3C SEMA3F SEMA4F VEGFA	2 interactors: DLG4 NRP2
Entrez ID		8828	10505
HPRD ID		03643	04748
Ensembl ID		ENSG00000118257
Uniprot IDs		O60462 Q7LBX6 Q7Z3T9	O95754
PDB IDs		2QQJ 2QQK 2QQL 2QQO
Enriched GO Terms of Interacting Partners?		Chemotaxis Axon Guidance Sprouting Angiogenesis Axonogenesis Axon Development Regulation Of Axon Extension Morphogenesis Of A Branching Epithelium Cell Morphogenesis Involved In Neuron Differentiation Morphogenesis Of A Branching Structure Locomotion Neuron Projection Morphogenesis Anatomical Structure Morphogenesis Regulation Of Axon Extension Involved In Axon Guidance Vascular Endothelial Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Negative Regulation Of Axon Extension Cell Part Morphogenesis Regulation Of Cell Size Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Neuron Development Response To External Stimulus Regulation Of Axonogenesis Cellular Response To Vascular Endothelial Growth Factor Stimulus Pattern Specification Process Ameboidal-type Cell Migration Cell Differentiation Cell Morphogenesis Blood Vessel Development Morphogenesis Of An Epithelium Neuron Differentiation Vasculature Development Cell Projection Organization Branching Morphogenesis Of An Epithelial Tube Patterning Of Blood Vessels Neural Crest Cell Migration Regulation Of Retinal Ganglion Cell Axon Guidance Tissue Morphogenesis Positive Regulation Of Endothelial Cell Proliferation System Development Negative Regulation Of Axonogenesis Neural Crest Cell Development Tube Development Coronary Artery Morphogenesis Regulation Of Developmental Growth Trigeminal Nerve Structural Organization	Vestibulocochlear Nerve Structural Organization Ganglion Morphogenesis Sensory Neuron Axon Guidance Axon Guidance Facioacoustic Ganglion Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Ventral Trunk Neural Crest Cell Migration Axonogenesis Maintenance Of Apical/basal Cell Polarity Hypothalamus Cell Migration Neural Crest Cell Migration Involved In Autonomic Nervous System Development Trigeminal Ganglion Development Neuron Cellular Homeostasis Axon Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Receptor Localization To Synapse Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Hypothalamus Cell Differentiation Axon Extension Involved In Axon Guidance Negative Regulation Of Receptor Internalization Vestibulocochlear Nerve Development Neuron Projection Morphogenesis Sympathetic Ganglion Development Locomotory Exploration Behavior Cellular Homeostasis Dendritic Spine Morphogenesis Facial Nerve Structural Organization Cell Morphogenesis Involved In Differentiation Synaptic Vesicle Maturation Facial Nerve Morphogenesis Maintenance Of Cell Polarity Cerebral Cortex Tangential Migration Vocalization Behavior Neuron Projection Development Ganglion Development Cell Projection Morphogenesis Cell Part Morphogenesis Dendritic Spine Development Protein Localization To Synapse Negative Regulation Of Receptor-mediated Endocytosis Negative Chemotaxis Parasympathetic Nervous System Development Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Dendritic Spine Organization Anatomical Structure Arrangement
Tagcloud ?		10a 200c 30a 30c arhgap5 cd36 cdh2 cdk5r1 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3	acetylcholinesterase affymetrix axon cdc42 correlative cytokinesis epha1 executed gtpase gtpases guidance hupa limk1 microarray morphological motility neurite nfat5 ntn4 outgrowth partly qrt rac rac2 reagents reversed rho sh sy5y
Tagcloud (Difference) ?		10a 200c 30a 30c arhgap5 cd36 cdh2 cdk5r1 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3	acetylcholinesterase affymetrix axon cdc42 correlative cytokinesis epha1 executed gtpase gtpases guidance hupa limk1 microarray morphological motility neurite nfat5 ntn4 outgrowth partly qrt rac rac2 reagents reversed rho sh sy5y
Tagcloud (Intersection) ?